Anti-FbxL4 antibody | MyBioSource MBS177027 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-FbxL4 antibody

catalog :

MBS177027

quantity :

0.1 mg

price :

315 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

image

image 1 :

Anti-FbxL4 antibody, MBS177027, Western blotting. Lane 1: Rat Liver Tissue Lysate. Lane 2: Rat Lung Tissue Lysate. Lane 3: HELA Cell Lysate. Lane 4: PANC Cell Lysate.

image 2 :

Anti-FbxL4 antibody, MBS177027, IHC(P). IHC(P): Human Lung Cancer Tissue

product information

catalog number :

MBS177027

products type :

Antibody

products full name :

Anti-FbxL4 antibody

products short name :

[FbxL4]

products name syn :

[F-box/LRR-repeat protein 4; F-box and leucine-rich repeat protein 4; F box and leucine rich repeat protein 4 antibody; F box protein FBL4/FBL5 antibody; F box/LRR repeat protein 4 antibody; F-box and leucine-rich repeat protein 4 antibody; F-box protein FBL 4 antibody; F-box protein FBL4/FBL5 antibody; F-box/LRR-repeat protein 4 antibody; FBL 4 antibody; FBL 5 antibody; FBL4 antibody; FBL5 antibody; Fbxl4 antibody; FBXL4_HUMAN antibody]

other names :

[F-box/LRR-repeat protein 4; F-box/LRR-repeat protein 4; F-box/LRR-repeat protein 4; F-box and leucine-rich repeat protein 4; F-box and leucine-rich repeat protein 4; F-box protein FBL4/FBL5]

products gene name :

[FBXL4]

other gene names :

[FBXL4; FBXL4; FBL4; FBL5; MTDPS13; FBL4; FBL5]

uniprot entry name :

FBXL4_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Predicted: Human, Rat. Predicted to work with: Mouse

sequence length :

621

specificity :

No cross reactivity with other proteins.

purity :

Immunogen affinity purified.

form :

Lyophilized

storage stability :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

app notes :

Western Blot:. Concentration: 0.1-0.5ug/ml. Tested Species: Hu, Rat. Predicted Species: Ms. Immunohistochemistry (Paraffin-embedded Section):. Concentration: 0.5-1ug/ml. Tested Species: Hu. Predicted Species: Ms, Rat. Antigen Retrieval: By Heat. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sectsions in 10mM citrate buffer, pH6.0 for mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human FbxL4 (552-565aa DELASNCTRLQQLD), different from the related mouse and rat sequences by one amino acid.

other info2 :

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

products description :

Description: Rabbit IgG polyclonal antibody for F-box/LRR-repeat protein 4(FBXL4) detection. Tested with WB, IHC-P in Human, Mouse, Rat. Background: FBXL4, also known as FBL4 or FBL5 encodes a member of the F-box protein family, which is characterized by an approximately 40 amino acid motif, the F-box. This gene is mapped to 6q16.1. F-box proteins constitute one subunit of modular E3 ubiquitin ligase complexes, called SCF complexes, which function in phosphorylation-dependent ubiquitination. The F-box domain mediates protein-protein interactions and binds directly to S-phase kinase-associated protein 1. In addition to an F-box domain, the encoded protein contains at least 9 tandem leucine-rich repeats. The ubiquitin ligase complex containing the encoded protein may function in cell-cycle control by regulating levels of lysine-specific demethylase 4A.

ncbi gi num :

21263631

ncbi acc num :

Q9UKA2.2

uniprot acc num :

Q9UKA2

ncbi mol weight :

70,097 Da

ncbi summary :

This gene encodes a member of the F-box protein family, which are characterized by an approximately 40 amino acid motif, the F-box. F-box proteins constitute one subunit of modular E3 ubiquitin ligase complexes, called SCF complexes, which function in phosphorylation-dependent ubiquitination. The F-box domain mediates protein-protein interactions and binds directly to S-phase kinase-associated protein 1. In addition to an F-box domain, the encoded protein contains at least 9 tandem leucine-rich repeats. The ubiquitin ligase complex containing the encoded protein may function in cell-cycle control by regulating levels of lysine-specific demethylase 4A. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

uniprot summary :

FBXL4: Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Chromosomal Location of Human Ortholog: 6q16.1-q16.3. Cellular Component: nucleoplasm; mitochondrial intermembrane space; ubiquitin ligase complex. Biological Process: ubiquitin-dependent protein catabolic process. Disease: Mitochondrial Dna Depletion Syndrome 13 (encephalomyopathic Type)

size1 :

0.1 mg

price1 :

315 USD

more info or order :

MyBioSource product webpage