Anti-Aromatase antibody | MyBioSource MBS176834 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-Aromatase antibody

catalog :

MBS176834

quantity :

0.1 mg

price :

315 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

image

image 1 :

Anti-Aromatase antibody, MBS176834, Western blotting. Lane 1: Rat Brain Tissue Lysate. Lane 2: Rat Thymus Tissue Lysate. Lane 3: Rat Kidney Tissue Lysate.

image 2 :

Anti-Aromatase antibody, MBS176834, IHC(P). IHC(P): Rat Brain Tissue

product information

catalog number :

MBS176834

products type :

Antibody

products full name :

Anti-Aromatase antibody

products short name :

[Aromatase]

products name syn :

[Cytochrome P450 19A1; cytochrome P450, family 19, subfamily A, polypeptide 1; ARO 1 antibody; ARO antibody; ARO1 antibody; Aromatase antibody; CP19A_HUMAN antibody; CPV antibody; CPV1 antibody; CYAR antibody; CYP19 antibody; CYP19A1 antibody; CYPXIX antibody; Cytochrome P-450AROM antibody; Cytochrome P450 19A1 antibody; Cytochrome P450 family 19 subfamily A polypeptide 1 antibody; Cytochrome P450, family 19, subfamily A, polypeptide 1 antibody; Cytochrome P450, subfamily XIX(aromatization of androgens) antibody; Estrogen synthase antibody; Estrogen synthetase antibody; Flavoprotein linked monooxygenase antibody; MGC104309 antibody; Microsomal monooxygenase antibody; OTTHUMP00000162543 antibody; OTTHUMP00000198350 antibody; P 450AROM antibody; P450AROM antibody]

other names :

[Aromatase; Aromatase; aromatase; CYPXIX; P-450AROM; estrogen synthase; estrogen synthetase; cytochrome P-450AROM; cytochrome P450 19A1; cytochrome P450, subfamily 19; Cytochrome P450, 19, aromatase; cytochrome P450 family 19 subfamily a; cytochrome P450, family 19, subfamily a, polypeptide 1; CYPXIX; Cytochrome P-450AROM; Cytochrome P450 19A1; Estrogen synthase]

products gene name :

[CYP19A1]

other gene names :

[Cyp19a1; Cyp19a1; Cyp19; Cyp19a; p450arom; Aromatase; Arom; Cyp19]

uniprot entry name :

CP19A_RAT

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Rat

sequence length :

508

purity :

Immunogen affinity purified.

form :

Lyophilized

storage stability :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of rat Aromatase (455-476aa LKRFHVKTLQKRCIENMPKNND).

other info2 :

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

products description :

Description: Rabbit IgG polyclonal antibody for Cytochrome P450 19A1(CYP19A1) detection. Tested with WB, IHC-P in Rat. Background: CYP19A1, also called Aromatase, is an enzyme responsible for a key step in the biosynthesis of estrogens. It is a member of the cytochrome P450 superfamily, which are monooxygenases that catalyze many reactions involved in steroidogenesis. In particular, aromatase is responsible for the aromatization of androgens into estrogens. The CYP19 gene spans at least 70 kb of genomic DNA and contains 10 exons. By in situ hybridization, the ARO gene is mapped to 15q21.1.The aromatase enzyme can be found in many tissues including gonads, brain, adipose tissue, placenta, blood vessels, skin, bone, and endometrium, as well as in tissue of endometriosis, uterine fibroids, breast cancer, and endometrial cancer. It is an important factor in sexual development. Some bodybuilders taking steroids also take antiaromatase supplements to prevent excess testosterone conversion into estrogens, which can cause gynecomastia.

ncbi gi num :

117295

ncbi acc num :

P22443.1

uniprot acc num :

P22443

ncbi mol weight :

58,412 Da

ncbi pathways :

C19/C18-Steroid Hormone Biosynthesis, Pregnenolone = Androstenedione = Estrone Pathway (434699); C19/C18-Steroid Hormone Biosynthesis, Pregnenolone = Androstenedione = Estrone Pathway (468268); Metabolic Pathways (132933); Metapathway Biotransformation (219788); Ovarian Infertility Genes Pathway (198450); Ovarian Steroidogenesis Pathway (791249); Ovarian Steroidogenesis Pathway (795173); Steroid Hormone Biosynthesis Pathway (83333); Steroid Hormone Biosynthesis Pathway (301); Tryptophan Metabolism Pathway (198467)

ncbi summary :

catalyzes end-step estrogen formation from androgens and aromatization of testosterone to estradiol [RGD, Feb 2006]

uniprot summary :

CYP19A1: Catalyzes the formation of aromatic C18 estrogens from C19 androgens. Belongs to the cytochrome P450 family. Protein type: EC 1.14.14.14; Oxidoreductase; Lipid Metabolism - androgen and estrogen. Cellular Component: synaptic vesicle; membrane; cell soma; endoplasmic reticulum; cytoplasm; dendritic spine; terminal button; synapse; nerve terminal; cytosol. Molecular Function: iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; heme binding. Biological Process: response to metal ion; hypothalamus development; dibenzo-p-dioxin metabolic process; response to morphine; progesterone metabolic process; estrogen biosynthetic process; response to organic cyclic substance; response to estradiol stimulus; biphenyl metabolic process; melatonin metabolic process; luteinization; negative regulation of bone resorption; response to drug; granulocyte differentiation; response to cesium; adrenal gland development; bile acid metabolic process; phthalate metabolic process; hippocampus development; androgen metabolic process; male gonad development; response to herbicide; response to testosterone stimulus; response to estrogen stimulus; regulation of synapse structure and activity; C21-steroid hormone metabolic process; response to ionizing radiation

size1 :

0.1 mg

price1 :

315 USD

more info or order :

MyBioSource product webpage