Anti-TMEM16A antibody | MyBioSource MBS176756 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-TMEM16A antibody

catalog :

MBS176756

quantity :

0.1 mg

price :

280 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

Anti-TMEM16A antibody, MBS176756, All Western blotting. All lanes: Anti-ANO1(MBS176756) at 0.5ug/ml. Lane 1: Rat Liver Tissue Lysate at 40ug. Lane 2: Rat Skeletal Muscle Tissue Lysate at 40ug. Predicted bind size: 114KD. Observed bind size: 114KD

product information

catalog number :

MBS176756

products type :

Antibody

products full name :

Anti-TMEM16A antibody

products short name :

[TMEM16A]

other names :

[Anoctamin-1; Anoctamin-1; anoctamin-1; Ca2+-activated Cl- channel; oral cancer overexpressed 2; tumor-amplified and overexpressed sequence 2; discovered on gastrointestinal stromal tumors protein 1; transmembrane protein 16A (eight membrane-spanning domains); anoctamin 1, calcium activated chloride channel; Discovered on gastrointestinal stromal tumors protein 1; Oral cancer overexpressed protein 2; Transmembrane protein 16A; Tumor-amplified and overexpressed sequence 2]

products gene name :

[ANO1]

other gene names :

[ANO1; ANO1; DOG1; TAOS2; ORAOV2; TMEM16A; DOG1; ORAOV2; TAOS2; TMEM16A]

uniprot entry name :

ANO1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Rat; Predicted: Human, Mouse

sequence length :

986

specificity :

No cross reactivity with other proteins.

purity :

Immunogen affinity purified.

form :

Lyophilized; Contains 5mg BSA, 0.9mg NaCl, 0.2mg Na 2 HPO 4 , 0.05mg Thimerosal, 0.05mg NaN 3 .

storage stability :

At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB)

app notes :

Western Blot . Concentration: 0.1-0.5 ug/mL. Tested Species: Rat (In-house tested species with positive results.). Predicted Species: Human, Mouse (Species predicted to be fit for the product based on sequence similarities.). Antigen Retrieval: -. Other applications have not been tested. Optimal dilutions should be determined by end users.

image1 heading :

Western Blot (WB)

other info1 :

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human ANO1 (927-943aa KVLMVELFMREEQDKQQ), different from the related mouse and rat sequences by one amino acid.

other info2 :

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

products description :

Anoctamin-1(ANO1), also known as oral cancer overexpressed 2(ORAOV2) or tumor-amplified and overexpressed sequence 2(TMEM16A), is a protein that in humans is encoded by the ANO1 gene. This gene belongs to a family of membrane proteins containing 8 transmembrane segments, and it is mapped to 11q13.3. ANO1 is a candidate calcium-activated chloride channel that mediates receptor-activated chloride currents in diverse physiologic processes, and it is though to be responsible for a voltage-sensitive calcium-activated chloride current. Its overexpression was reported in esophageal squamous cell carcinoma and breast cancer progression Crofelemer, an antidiarrhoeal, inhibits this channel. ANO1 has eight transmembrane domains, its pore is large and non-selective, allowing other negatively charged species to permeate.

ncbi gi num :

74708278

ncbi acc num :

Q5XXA6.1

uniprot acc num :

Q5XXA6

ncbi pathways :

Ion Channel Transport Pathway (187193); Stimuli-sensing Channels Pathway (771568); Transmembrane Transport Of Small Molecules Pathway (106572)

uniprot summary :

ANO1: Acts as a calcium-activated chloride channel. Required for normal tracheal development. Belongs to the anoctamin family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, multi-pass; Transporter, ion channel; Transporter; Membrane protein, integral. Chromosomal Location of Human Ortholog: 11q13.3. Cellular Component: apical plasma membrane; cytoplasm; plasma membrane; external side of plasma membrane. Molecular Function: protein binding; protein homodimerization activity; intracellular calcium activated chloride channel activity; protein heterodimerization activity; calcium activated cation channel activity. Biological Process: regulation of membrane potential; multicellular organismal development; chloride transport; transmembrane transport; cation transport

size1 :

0.1 mg

price1 :

280 USD

more info or order :

MyBioSource product webpage