Human SCGB1A1/uteroglobin PicoKine ELISA Kit | MyBioSource MBS176550 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human SCGB1A1/uteroglobin PicoKine ELISA Kit

catalog :

MBS176550

quantity :

96 Wells

price :

425 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS176550

products type :

ELISA Kit

products full name :

Human SCGB1A1/uteroglobin PicoKine ELISA Kit

products short name :

SCGB1A1/uteroglobin

products name syn :

Uteroglobin; secretoglobin, family 1A, member 1 (uteroglobin); blastokinin; CC10; CC16; CCPBP; CCSP; Clara cell phospholipid binding protein; Clara cell phospholipid-binding protein; clara cell secretory protein; Clara cell specific 10 kD protein; Clara Cells 10 kDa Secretory Protein; OTTHUMP00000236107; SCGB1A1; Secretoglobin family 1A member 1; Secretoglobin, family 1A, member 1 (uteroglobin); UG; UGB; UP-1; UP1; Urinary Protein 1; Urine Protein 1; UTER_HUMAN; Uteroglobin; Utg

other names :

Uteroglobin; Uteroglobin; uteroglobin; blastokinin; urine protein 1; urinary protein 1; clara cells 10 kDa secretory protein; clara cell phospholipid-binding protein; secretoglobin, family 1A, member 1 (uteroglobin); Clara cell phospholipid-binding protein; CCPBP; Clara cells 10 kDa secretory protein; CC10; Secretoglobin family 1A member 1; Urinary protein 1; UP-1; UP1; Urine protein 1

products gene name :

SCGB1A1

other gene names :

SCGB1A1; SCGB1A1; UGB; UP1; CC10; CC16; CCSP; UP-1; CCPBP; CC10; CCSP; UGB; CCPBP; CC10; UP-1; UP1; Urine protein 1

uniprot entry name :

UTER_HUMAN

reactivity :

Human

sequence length :

specificity :

Natural and recombinant human SCGB1A1

storage stability :

Store at 4 degree C for 6 months, at -20 degree C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)

other info1 :

Samples: Cell culture supernates, serum, plasma (heparin, EDTA), saliva, urine and human milk. Assay Type: Sandwich. Detection Range: 156pg/ml-10,000pg/ml. Sensitivity: < 10pg/ml

other info2 :

Intra-assay Precision: Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested on one plate to assess intra-assay precision. Inter-assay Precision: Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay precision.

products description :

Principle of the assay: human SCGB1A1 ELISA Kit was based on standard sandwich enzyme-linked immune-sorbent assay technology. A monoclonal antibody from mouse specific for SCGB1A1 has been precoated onto 96-well plates. Standards(E.coli, E22-N91) and test samples are added to the wells, a biotinylated detection polyclonal antibody from goat specific for SCGB1A1 is added subsequently and then followed by washing with PBS or TBS buffer. Avidin-Biotin-Peroxidase Complex was added and unbound conjugates were washed away with PBS or TBS buffer. HRP substrate TMB was used to visualize HRP enzymatic reaction. TMB was catalyzed by HRP to produce a blue color product that changed into yellow after adding acidic stop solution. The density of yellow is proportional to the human SCGB1A1 amount of sample captured in plate. Background: SCGB1A1(secretoglobin family 1A member 1) also known as Uteroglobin is a protein that in humans is encoded by the SCGB1A1 gene. SCGB1A1 is the founding member of the secretoglobin family of small, secreted, disulfide-bridged dimeric proteins found only in mammals. This protein is specifically expressed in Clara cells in the lungs. Numerous studies demonstrated that UG is a multifunctional protein with antiinflammatory/ immunomodulatory properties. It inhibits soluble phospholipase A(2) activity and binds and perhaps sequesters hydrophobic ligands such as progesterone, retinols, polychlorinated biphenyls, phospholipids, and prostaglandins. In addition to its antiinflammatory activities, UG manifests antichemotactic, antiallergic, antitumorigenic, and embryonic growth-stimulatory activities.

ncbi gi num :

112672

ncbi acc num :

P11684.1

uniprot acc num :

P11684

ncbi mol weight :

9,994 Da

ncbi pathways :

FOXA1 Transcription Factor Network Pathway (137979); Prostaglandin Synthesis And Regulation Pathway (198912)

ncbi summary :

This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010]

uniprot summary :

SCGB1A1: Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2. Belongs to the secretoglobin family. Protein type: Cell cycle regulation; Secreted, signal peptide; Inhibitor; Secreted. Chromosomal Location of Human Ortholog: 11q12.3. Cellular Component: extracellular space; rough endoplasmic reticulum; nuclear envelope; secretory granule. Molecular Function: protein binding; phospholipase A2 inhibitor activity. Biological Process: response to drug; negative regulation of interleukin-4 production; response to glucocorticoid stimulus; response to lipopolysaccharide; negative regulation of transcription from RNA polymerase II promoter; female pregnancy; signal transduction; regulation of mRNA stability; response to xenobiotic stimulus; negative regulation of interleukin-13 production; response to silicon dioxide; negative regulation of T cell proliferation; response to ozone; response to cytokine stimulus; negative regulation of interferon-gamma production; regulation of inflammatory response; negative regulation of catalytic activity; negative regulation of interleukin-5 production; embryo implantation. Disease: Asthma, Susceptibility To

size1 :

96 Wells

price1 :

425 USD

more info or order :

MyBioSource product webpage