antibody

Anti-RGS3 antibody

MBS176390

0.1 mg

245 USD

polyclonal

rabbit

nonconjugated

mouse, rat

western blot, immunohistochemistry, immunohistochemistry - paraffin section

Antibody

Anti-RGS3 antibody

RGS3

Regulator of G-protein signaling 3; regulator of G-protein signaling 3; C2PA antibody; FLJ20370 antibody; FLJ31516 antibody; FLJ90496 antibody; PDZ RGS 3 antibody; PDZ RGS3 antibody; Regulator of G protein signaling 3 antibody; Regulator of G protein signalling 3 antibody; Regulator of G-protein signaling 3 antibody; RGP 3 antibody; RGP3 antibody; RGS 3 antibody; RGS3 antibody; RGS3_HUMAN antibody

Regulator of G-protein signaling 3; Regulator of G-protein signaling 3; regulator of G-protein signaling 3; C2 membrane binding, PDZ protein/protein interaction, ATP/GTP binding domains; regulator of G-protein signaling 3; C2PA

Rgs3

Rgs3; Rgs3; C2pa; RGS3S; PDZ-RGS3; C2PA-RGS3; 4930506N09Rik; RGS3

RGS3_MOUSE

Polyclonal

IgG

Rabbit

Reacts with: Human, Rat . Predicted to work with: Mouse

966

Immunogen affinity purified.

Lyophilized

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Western Blot:. Concentration: 0.1-0.5ug/ml. Tested Species: Hu, Rat. Predicted Species: Ms. Antigen Retrieval: -. Immunohistochemistry (Paraffin-embedded Section): . Concentration: 0.5-1ug/ml. Tested Species: Hu, Rat. Predicted Species: Ms. Antigen Retrieval: By Heat. Tested Species: in-house tested species with positive results. Predicted Species: Species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/ paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of mouse RGS3 (909-925aa DSYTREHTKENLQSITR), identical to the related rat sequence, and different from the related human sequence by two amino acids.

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Description: Rabbit IgG polyclonal antibody for Regulator of G-protein signaling 3(Rgs3) detection. Tested with WB, IHC-P in Human, Mouse, Rat. Background: RGS3(Regulator of G Protein Signaling 3), is a protein that in humans is encoded by the RGS3 gene. Chatterjee et al.(1997) studied RGS3, the largest member of the RGS family then identified. Mouse Pdz-Rgs3 can mediate signaling from the ephrin-B cytoplasmic tail. By radiation hybrid mapping, Chatterjee et al.(1997) assigned the RGS3 gene to chromosome 9q31-q33. Lu et al.(2001) showed that Sdf1, a chemokine with a G protein-coupled receptor, and Bdnf are chemoattractants for cerebellar granule cells, and that Sdf1 chemoattraction is selectively inhibited by soluble ephrin-B receptor. This inhibition could be blocked by a truncated Pdz-Rgs3 protein lacking the RGS domain.

67477416

Q9DC04.2

Q9DC04

Axon Guidance Pathway (83262); Axon Guidance Pathway (476); Calcium Regulation In The Cardiac Cell Pathway (198327); Myometrial Relaxation And Contraction Pathways (198333)

RGS3: Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G- protein-mediated release of inositol phosphates and activation of MAP kinases. 6 isoforms of the human protein are produced by alternative splicing. Protein type: GAPs; GAPs, RGS. Cellular Component: nucleoplasm; membrane; cytoplasm; plasma membrane; nucleus. Molecular Function: GTPase activator activity. Biological Process: G-protein coupled receptor protein signaling pathway; signal transduction; negative regulation of signal transduction; positive regulation of GTPase activity

0.1 mg

245 USD