Polyclonal Anti-CSF3R Antibody | MyBioSource MBS176365 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Polyclonal Anti-CSF3R Antibody

catalog :

MBS176365

quantity :

0.1 mg

price :

280 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

Anti-GCSF Receptor antibody, MBS176365, Western blotting. WB: Human Placenta Tissue Lysate

product information

catalog number :

MBS176365

products type :

Antibody

products full name :

Polyclonal Anti-CSF3R Antibody

products short name :

[GCSF Receptor]

products name syn :

[Granulocyte colony-stimulating factor receptor; Colony stimulating factor 3 receptor(granulocyte); CD 114 antibody; CD114 antibody; CD114 antigen antibody; Colony stimulating factor 3 receptor(granulocyte) antibody; Colony stimulating factor 3 receptor antibody; CSF 3R antibody; CSF3R antibody; CSF3R_HUMAN antibody; Csfgr antibody; G CSF R antibody; G-CSF receptor antibody; G-CSF-R antibody; GCSFR antibody; Granulocyte colony stimulating factor receptor antibody; Granulocyte colony stimulating factor receptor precursor antibody; Granulocyte colony-stimulating factor receptor antibody; OTTHUMP00000009703 antibody; OTTHUMP00000009704 antibody; OTTHUMP00000009705 antibody]

other names :

[Granulocyte colony-stimulating factor receptor; Granulocyte colony-stimulating factor receptor; granulocyte colony-stimulating factor receptor; G-CSF-R; CD114 antigen; G-CSF receptor; colony stimulating factor 3 receptor (granulocyte); CD_antigen: CD114]

products gene name :

[CSF3R]

other gene names :

[CSF3R; CSF3R; CD114; GCSFR; GCSFR; G-CSF receptor; G-CSF-R]

uniprot entry name :

CSF3R_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

836

specificity :

No cross reactivity with other proteins.

purity :

Immunogen affinity purified.

form :

Lyophilized

storage stability :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB)

app notes :

Western Blot:. Concentration: 0.1-0.5ug/ml. Tested Species: Hu. WB: The detection limit for CSF3R is approximately 5ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: species predicted to be fit for the product based on sequence similarities. Other applications have not been tesetd. Optimal dilutions should be determined by end users.

image1 heading :

Western Blot (WB)

other info1 :

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human GCSF Receptor (254-271aa EPWQPGLHINQKCELRHK).

other info2 :

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

products description :

Description: Rabbit IgG polyclonal antibody for Granulocyte colony-stimulating factor receptor(CSF3R) detection. Tested with WB in Human. Background: CSF3R(Colony-Stimulating Factor 3 Receptor, Granulocyte) also known as GCSFR or CD114((Cluster of Differentiation 114) is a protein that in humans is encoded by the CSF3R gene. G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor(G-CSF). The G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family. The CSF3R gene consists of 17 exons. By in situ hybridization using human CSF3R cDNA as a probe, Inazawa et al.(1991) localized the gene to 1p35-p34.3. The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction. GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, STAT, and Erk1/2. Dong et al.(2001) reported that the C terminus of CSF3R is required for SHP1 downregulation of CSF3-induced STAT activation. The authors proposed that this mechanism inhibits cell proliferation and survival in response to CSF3.

ncbi gi num :

729564

ncbi acc num :

Q99062.1

uniprot acc num :

Q99062

ncbi pathways :

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Jak-STAT Signaling Pathway (83077); Jak-STAT Signaling Pathway (488); PI3K-Akt Signaling Pathway (692234); PI3K-Akt Signaling Pathway (692979); Pathways In Cancer (83105)

ncbi summary :

The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. [provided by RefSeq, Aug 2010]

uniprot summary :

GCSFR: the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Four transcript variant isoforms have been described. Protein type: Receptor, cytokine; Membrane protein, integral. Chromosomal Location of Human Ortholog: 1p35-p34.3. Cellular Component: integral to plasma membrane; extracellular region. Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; receptor activity. Biological Process: neutrophil chemotaxis; cytokine and chemokine mediated signaling pathway; defense response; cell adhesion; signal transduction. Disease: Neutrophilia, Hereditary

size1 :

0.1 mg

price1 :

280 USD

more info or order :

MyBioSource product webpage