Anti-VEGF Receptor 1 antibody | MyBioSource MBS176292 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-VEGF Receptor 1 antibody

catalog :

MBS176292

quantity :

0.1 mg

price :

245 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

rat

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS176292

products type :

Antibody

products full name :

Anti-VEGF Receptor 1 antibody

products short name :

VEGF Receptor 1

products name syn :

Vascular endothelial growth factor receptor 1; fms-related tyrosine kinase 1; EC 2.7.10.1 antibody; Flt 1 antibody; FLT antibody; Flt-1 antibody; Flt1 antibody; Fms like tyrosine kinase 1 antibody; Fms related tyrosine kinase 1(vascular endothelial growth factor/vascular permeability factor receptor) antibody; Fms related tyrosine kinase 1 antibody; Fms related tyrosine kinase 1 vascular endothelial growth factor/vascular permeability factor receptor antibody; Fms-like tyrosine kinase 1 antibody; FRT antibody; Soluble VEGF receptor 1 14 antibody; Soluble VEGFR1 variant 2 antibody; Soluble VEGFR1 variant 21 antibody; Tyrosine protein kinase FRT antibody; Tyrosine protein kinase receptor FLT antibody; Tyrosine-protein kinase FRT antibody; Tyrosine-protein kinase receptor FLT antibody; Vascular endothelial growth factor receptor 1 antibody; Vascular endothelial growth factor receptor 1 Precursor antibody; Vascular endothelial growth factor vascular permeability factor receptor antibody; Vascular permeability factor receptor 1 antibody; Vascular permeability factor receptor antibody; VEGFR 1 antibody; VEGFR-1 antibody; VEGFR1 antibody; VGFR1_HUMAN antibody

other names :

Vascular endothelial growth factor receptor 1; Vascular endothelial growth factor receptor 1; vascular endothelial growth factor receptor 1; FLT-1; FMS-like tyrosine kinase 1; tyrosine-protein kinase receptor FLT; vascular endothelial growth factor receptor-1; Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); FMS-related tyrosine kinase 1; Fms-like tyrosine kinase 1; FLT-1; Tyrosine-protein kinase receptor FLT

products gene name :

FLT1

other gene names :

Flt1; Flt1; VEGFR-1; Flt-1; Vegfr1; VEGFR-1; FLT-1

uniprot entry name :

VGFR1_RAT

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Rat

sequence length :

1336

specificity :

No Cross reactivity with other proteins.

purity :

Immunogen affinity purified.

form :

Lyophilized

storage stability :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB)

app notes :

Western Blot:. Concentration: 0.1-0.5 ug/ml. Tested Species: Rat. Predicted Species: - . Antigen Retrieval: - . WB: The detection limit for FLT1 is approximately 0.5ng/lane under reducing conditions. . Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarites. Other applications have not been tested. Optimal dilutions should be determined by end users.

other info1 :

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of rat FLT1 (278-298aa IRQRIDQSNPHSNVFHSVLKI).

other info2 :

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

products description :

Description: Rabbit IgG polyclonal antibody for Vascular endothelial growth factor receptor 1(FLT1) detection. Tested with WB in Rat. Background: Vascular endothelial growth factor receptor 1(FLT1) is a protein that in humans is encoded by the FLT1 gene. Oncogene FLT belongs to the src gene family. It is mapped to 13q12. The deduced 1,338-amino acid protein has a calculated molecular mass of 150.6 kD. It has a 758-amino acid extracellular domain, followed by a 22-amino acid transmembrane region and a 558-amino acid cytoplasmic region containing a cluster of basic amino acids and a tyrosine kinase domain. sFLT-1 was identified in placenta, adult lung, kidney, liver and uterus. Like other members of this family, it shows tyrosine protein kinase activity that is important for the control of cell proliferation and differentiation.

ncbi gi num :

1718161

ncbi acc num :

P53767.1

uniprot acc num :

P53767

ncbi mol weight :

150,250 Da

ncbi pathways :

Cytokine-cytokine Receptor Interaction Pathway (83443); Cytokine-cytokine Receptor Interaction Pathway (460); Endocytosis Pathway (102267); Endocytosis Pathway (102181); Focal Adhesion Pathway (83459); Focal Adhesion Pathway (478); HIF-1 Signaling Pathway (695233); Id Signaling Pathway (198536); PI3K-Akt Signaling Pathway (692247); PI3K-Akt Signaling Pathway (692979)

ncbi summary :

tyrosine kinase receptor for vascular endothelial growth factor; may play a role in cell proliferation and cell survival [RGD, Feb 2006]

uniprot summary :

VEGFR1: a receptor tyrosine kinase of the VEGFR family. Receptor for VEGF, VEGFB and PGF. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Two splice variant isoforms have been described. Isoform SFlt1 may have an inhibitory role in angiogenesis. Protein type: Protein kinase, tyrosine (receptor); Membrane protein, integral; Protein kinase, TK; EC 2.7.10.1; Kinase, protein; TK group; VEGFR family. Cellular Component: focal adhesion; integral to plasma membrane; plasma membrane; receptor complex; endosome. Molecular Function: vascular endothelial growth factor receptor activity; identical protein binding; growth factor binding; transmembrane receptor protein tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; ATP binding. Biological Process: peptidyl-tyrosine phosphorylation; activation of MAPKK activity; protein amino acid autophosphorylation; positive regulation of smooth muscle cell proliferation; chemotaxis; protein amino acid phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of MAP kinase activity; monocyte chemotaxis; positive regulation of fibroblast proliferation; positive regulation of cell proliferation; angiogenesis; embryonic morphogenesis; cell differentiation; regulation of smooth muscle contraction; cell migration; intracellular receptor-mediated signaling pathway; positive regulation of phosphoinositide 3-kinase activity; patterning of blood vessels; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of angiogenesis; response to hypoxia; blood vessel morphogenesis; sprouting angiogenesis; vascular endothelial growth factor receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration

size1 :

0.1 mg

price1 :

245 USD

more info or order :

MyBioSource product webpage