antibody

Anti-TNF Receptor II antibody

MBS176278

0.1 mg

280 USD

polyclonal

rabbit

nonconjugated

mouse, rat

Antibody

Anti-TNF Receptor II antibody

[TNF Receptor II]

[Tumor necrosis factor receptor superfamily member 1B; tumor necrosis factor receptor superfamily, member 1B; CD 120b antibody; CD120b antibody; CD120b antigen antibody; Etanercept antibody; p75 antibody; p75TNFR antibody; p80 TNF alpha receptor antibody; p80 TNF-alpha receptor antibody; TBP-2 antibody; TBP2 antibody; TBPII antibody; TNF R II antibody; TNF R2 antibody; TNF R75 antibody; TNF-R2 antibody; TNF-RII antibody; TNFBR antibody; TNFR 2 antibody; TNFR-II antibody; TNFR2 antibody; TNFR75 antibody; TNFR80 antibody; TNFRII antibody; TNFRSF 1B antibody; TNFRSF1B antibody; TNR1B antibody; TNR1B_HUMAN antibody; Tumor necrosis factor beta receptor antibody; Tumor necrosis factor binding protein 2 antibody; Tumor necrosis factor receptor 2 antibody; Tumor necrosis factor receptor superfamily member 1B precursor antibody; Tumor necrosis factor receptor type II antibody; Tumor necrosis factor-binding protein 2 antibody]

[Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor superfamily member 1B; tumor necrosis factor receptor superfamily member 1B; TNF-RII; TNFR-II; p75 TNFR; p80 TNF-alpha receptor; TNF receptor beta chain; tumor necrosis factor receptor 2; tumor necrosis factor receptor type II; tumor necrosis factor receptor superfamily, member 1b; Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; TNF-RII; TNFR-II; p75; p80 TNF-alpha receptor; CD_antigen: CD120b]

[TNFRSF1B]

[Tnfrsf1b; Tnfrsf1b; p75; TNFBR; Tnfr2; CD120b; TNF-R2; TNFR80; TNFRII; Tnfr-1; TNF-R75; TNF-R-II; TNF-alphaR2; TNFalpha-R2; Tnfr-2; Tnfr2; TNF-R2; TNF-RII; TNFR-II]

TNR1B_MOUSE

Polyclonal

IgG

Rabbit

Mouse, Rat

474

No cross reactivity with other proteins.

Immunogen affinity purified.

Lyophilized

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Western Blot (WB)

Western Blot:. Concentration: 0.1-0.5ug/ml. Tested Species: Ms, Rat. WB: The detection limit for TNFRSF1B is approximately 1ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Western Blot (WB)

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of mouse TNF Receptor II (38-55aa YECQISQEYYDRKAQMCC), different from the related rat sequence by three amino acids.

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Description: Rabbit IgG polyclonal antibody for Tumor necrosis factor receptor superfamily member 1B(TNFRSF1B) detection. Tested with WB in Mouse, Rat. Background: TNFRSF1B(Tumor Necrosis Factor Receptor Subfamily Member 1B), also known as TNFR2 or TNFBR, is a protein that in humans is encoded by the TNFRSF1B gene. The protein encoded by this gene is a member of the Tumor necrosis factor receptor superfamily, which also contains TNFRSF1A. By linkage analysis, Santee and Owen Schaub(1996) confirmed the mapping of the TNFR2 gene to 1p36.3-p36.2. TNFBR(TNFR75) is the larger of the 2 TNF receptors. It is present on many cell types, especially those of myeloid origin, and is strongly expressed on stimulated T and B lymphocytes. Beltinger et al.(1996) noted that TNFR2 is the main TNF receptor found on circulating T cells and is the major mediator of autoregulatory apoptosis in CD8+ cells. TNFR2 may act with TNFR1 to kill nonlymphoid cells.

135963

P25119.1

P25119

50,320 Da

Adipocytokine Signaling Pathway (83290); Adipocytokine Signaling Pathway (505); Amyotrophic Lateral Sclerosis (ALS) Pathway (83296); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); Apoptosis Pathway (198339); Cytokine-cytokine Receptor Interaction Pathway (83248); Cytokine-cytokine Receptor Interaction Pathway (460); IL-3 Signaling Pathway (198420); Inflammatory Response Pathway (198280); Oxidative Damage Pathway (198311)

TNF-R2: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. Binds to TRAF2. Interacts with BMX. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, cytokine. Cellular Component: cell soma; membrane; axon; perinuclear region of cytoplasm; integral to membrane; intracellular; nucleus; lipid raft. Molecular Function: protein binding; tumor necrosis factor receptor activity; ubiquitin protein ligase binding. Biological Process: cell proliferation; cell surface receptor linked signal transduction; DNA damage response, signal transduction resulting in induction of apoptosis; tumor necrosis factor-mediated signaling pathway; negative regulation of inflammatory response; programmed cell death; immune response; inflammatory response; RNA destabilization; positive regulation of membrane protein ectodomain proteolysis

0.1 mg

280 USD