Anti-mouse Growth Hormone antibody | MyBioSource MBS176203 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-mouse Growth Hormone antibody

catalog :

MBS176203

quantity :

0.1 mg

price :

280 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

mouse

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS176203

products type :

Antibody

products full name :

Anti-mouse Growth Hormone antibody

products short name :

Growth Hormone

products name syn :

Somatotropin; growth hormone 1; gH antibody; GH-N antibody; GH1 antibody; Growth hormone 1 antibody; Growth hormone antibody; hGH-N antibody; IGHD1B antibody; Pituitary growth hormone antibody; Somatotropin antibody

other names :

Somatotropin; Somatotropin; somatotropin; growth hormone; Growth hormone

products gene name :

GH1

other gene names :

Gh; Gh1; Gh1; Gh

uniprot entry name :

SOMA_MOUSE

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Mouse

sequence length :

216

purity :

Immunogen affinity purified.

form :

Lyophilized

storage stability :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB)

other info1 :

Immunogen: E Coli-derived mouse GH recombinant protein (Position: F27-F216).

other info2 :

Contents: Each vial contains 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

products description :

Description: Rabbit IgG polyclonal antibody for Somatotropin(GH1) detection. Tested with WB in Mouse. Background: Growth Hormone(GH) is mapped to 17q22-q24. Growth hormone(GH) is synthesized by acidophilic or somatotropic cells of the anterior pituitary gland. Human growth hormone has a molecular mass of 22,005 and contains 191 amino acid residues with 2 disulfide bridges. It binds two receptor molecules and thereby induces signal transduction through receptor dimerization. At high concentrations, GH acts as an antagonist because of a large difference in affinities at the respective binding sites.

ncbi gi num :

134708

ncbi acc num :

P06880.1

uniprot acc num :

P06880

ncbi mol weight :

24,716 Da

ncbi pathways :

Adipogenesis Pathway (198299); Cytokine Signaling In Immune System Pathway (970814); Growth Hormone Receptor Signaling Pathway (1001294); Immune System Pathway (971216); Jak-STAT Signaling Pathway (83274); Jak-STAT Signaling Pathway (488); Metabolism Of Proteins Pathway (970583); Neuroactive Ligand-receptor Interaction Pathway (83250); Neuroactive Ligand-receptor Interaction Pathway (462); Nuclear Signaling By ERBB4 Pathway (1000926)

uniprot summary :

GH: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Defects in GH1 are a cause of growth hormone deficiency isolated type 1A (IGHD1A); also known as pituitary dwarfism I. IGHD1A is an autosomal recessive deficiency of GH which causes short stature. IGHD1A patients have an absence of GH with severe dwarfism and often develop anti-GH antibodies when given exogenous GH. Defects in GH1 are a cause of growth hormone deficiency isolated type 1B (IGHD1B); also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. Dwarfism is less severe than in IGHD1A and patients usually respond well to exogenous GH. Defects in GH1 are the cause of Kowarski syndrome (KWKS); also known as pituitary dwarfism VI. Defects in GH1 are a cause of growth hormone deficiency isolated type 2 (IGHD2). IGHD2 is an autosomal dominant deficiency of GH which causes short stature. Clinical severity is variable. Patients have a positive response and immunologic tolerance to growth hormone therapy. Belongs to the somatotropin/prolactin family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted; Hormone. Cellular Component: extracellular space; mitochondrion; plasma membrane; extracellular region; trans-Golgi network; cytosol; nucleus; secretory granule. Molecular Function: growth hormone receptor binding; hormone activity; metal ion binding. Biological Process: response to food; response to light stimulus; positive regulation of neurogenesis; cellular response to insulin stimulus; neuroblast proliferation; positive regulation of multicellular organism growth; regulation of steroid hormone receptor signaling pathway; glucose transport; signal transduction; alveolus development; positive regulation of growth

size1 :

0.1 mg

price1 :

280 USD

more info or order :

MyBioSource product webpage