Anti-NRF1 antibody | MyBioSource MBS176123 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-NRF1 antibody

catalog :

MBS176123

quantity :

0.1 mg

price :

245 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS176123

products type :

Antibody

products full name :

Anti-NRF1 antibody

products short name :

NRF1

products name syn :

Nuclear respiratory factor 1; nuclear respiratory factor 1; alpha pal antibody; alpha palindromic binding protein antibody; Alpha palindromic-binding protein antibody; Alpha-pal antibody; locus control region factor 1 antibody; NFE2 related factor 1 antibody; NRF-1 antibody; Nrf1 antibody; NRF1_HUMAN antibody; nuclear factor(erythroid derived 2)-like 1 antibody; nuclear respiratory factor 1 antibody; transcription factor 11 antibody

other names :

Nuclear respiratory factor 1; Nuclear respiratory factor 1; nuclear respiratory factor 1; alpha palindromic-binding protein; nuclear respiratory factor 1; Alpha palindromic-binding protein; Alpha-pal

products gene name :

NRF1

other gene names :

NRF1; NRF1; ALPHA-PAL; NRF-1; Alpha-pal

uniprot entry name :

NRF1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

503

purity :

Immunogen affinity purified.

form :

Lyophilized

storage stability :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC)

other info1 :

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human NRF1 (272-288aa QHGREDLLYAFEDQQTQ), identical to the related rat and mouse sequences.

other info2 :

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

products description :

Description: Rabbit IgG polyclonal antibody for Nuclear respiratory factor 1(NRF1) detection. Tested with WB, IHC-P, ICC in Human, Mouse, Rat. Background: NRF1(Nuclear Respiratory Factor 1), also known as Alpha-Pal. Gopalakrishnan and Scarpulla(1995) analyzed DNA from a panel of human/hamster cell hybrids using human-specific NRF1 PCR primers and localized the NRF1 gene to human chromosome 7. The assignment was further refined to 7q31 by cohybridization of NRF1- and chromosome 7-specific probes to human metaphase chromosomes. Efiok et al.(1994) identified genes containing alpha-Pal-binding sequences and found that these could be classified either as cellular proliferation genes, or as genes regulating the growth-responsive metabolic pathways of energy transduction, translation, and replication. Virbasius and Scarpulla(1994) noted that the nuclear-encoded mitochondrial transcription factor TFAM contains potential binding sites for NRF1, NRF2(GABPA) and SP1 within the promoter region. With use of binding and electrophoretic mobility shift assays, DNase footprinting, and mutation analysis of recombinant proteins, they demonstrated specific and functional binding of NRF1 and NRF2 to the TFAM promoter region.

ncbi gi num :

12643732

ncbi acc num :

Q16656.1

uniprot acc num :

Q16656

ncbi mol weight :

55,674 Da

ncbi pathways :

Energy Metabolism Pathway (198907); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (160977); Huntington's Disease Pathway (83100); Huntington's Disease Pathway (512); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); Mitochondrial Gene Expression Pathway (198757); Mitochondrial Biogenesis Pathway (980486); Organelle Biogenesis And Maintenance Pathway (980485); PPARA Activates Gene Expression Pathway (530749)

ncbi summary :

This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014]

uniprot summary :

NRF1: Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. Belongs to the NRF1/Ewg family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 7q32. Cellular Component: nucleoplasm; cytoplasm. Biological Process: regulation of transcription from RNA polymerase II promoter; mitochondrion organization and biogenesis; generation of precursor metabolites and energy; organ regeneration; transcription, DNA-dependent; response to folic acid; organelle organization and biogenesis; response to hypoxia; response to lipopolysaccharide; positive regulation of transcription from RNA polymerase II promoter; cellular lipid metabolic process; response to electrical stimulus; response to estradiol stimulus

size1 :

0.1 mg

price1 :

245 USD

more info or order :

MyBioSource product webpage