antibody

Anti-Parathyroid Hormone Receptor 1 antibody

MBS176015

0.1 mg

245 USD

polyclonal

rabbit

nonconjugated

human, rat

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

Antibody

Anti-Parathyroid Hormone Receptor 1 antibody

Parathyroid Hormone Receptor 1

Parathyroid hormone/parathyroid hormone-related peptide receptor; parathyroid hormone 1 receptor; MGC138426 antibody; MGC138452 antibody; Parathyroid hormone 1 receptor antibody; Parathyroid hormone/parathyroid hormone related peptide receptor antibody; Parathyroid hormone/parathyroid hormone related protein receptor antibody; Parathyroid hormone/parathyroid hormone-related peptide receptor antibody; PTH receptor antibody; PTH/PTHr receptor antibody; PTH/PTHrP receptor antibody; PTH/PTHrP type I receptor antibody; PTH1 receptor antibody; PTH1R antibody; PTH1R_HUMAN antibody; PTHR 1 antibody; PTHR antibody; PTHR1 antibody

Parathyroid hormone/parathyroid hormone-related peptide receptor; Parathyroid hormone/parathyroid hormone-related peptide receptor; parathyroid hormone/parathyroid hormone-related peptide receptor; PTH1 receptor; PTH/PTHr receptor; PTH/PTHrP type I receptor; parathyroid hormone receptor 1; seven transmembrane helix receptor; parathyroid hormone/parathyroid hormone-related protein receptor; parathyroid hormone 1 receptor; PTH/PTHrP type I receptor; PTH/PTHr receptor; Parathyroid hormone 1 receptor; PTH1 receptor

PTH1R

PTH1R; PTH1R; PFE; PTHR; PTHR1; PTHR; PTHR1; PTH/PTHr receptor; PTH1 receptor

PTH1R_HUMAN

Polyclonal

IgG

Rabbit

Reacts with: Human. Predicted to work with: Mouse, Rat

593

No cross reactivity with other proteins.

Immunogen affinity purified.

Lyophilized

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC)

Western Blot:. Concentration: 0.1-0.5ug/ml. Tested Species: Hu. Predicted Species: Ms, Rat. Antigen Retrieval: -. Immunohistochemistry (Paraffin-embedded Section):. Concentration: 0.5-1ug/ml. Tested Species: Hu. Predicted Species: Ms, Rat. Antigen Retrieval: By Heat. Immunocytochemistry:. Concentration: 0.5-1ug/ml. Tested Species: Hu. Predicted Species: Ms, Rat. Antigen Retrieval: -. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sectins. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Parathyroid Hormone Receptor 1 (388-406aa KLRETNAGRCDTRQQYRKL), identical to the related mouse and rat sequences.

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Description: Rabbit IgG polyclonal antibody for Parathyroid hormone/parathyroid hormone-related peptide receptor(PTH1R) detection. Tested with WB, IHC-P, ICC in Human, Mouse, Rat. Background: Parathyroid hormone/parathyroid hormone-related peptide receptor, also known as PTH1R, PTHR, is a protein that in humans is encoded by the PTH1R gene. PTHR is a member of a family of G protein-coupled receptors. PTHR gene was mapped to the vicinity of the 3p21.3-p21.2 boundary by PCR analysis of human/rodent somatic cell hybrid panels using oligonucleotide primers designed to amplify a portion of the gene from genomic DNA. This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. PTH1R functions as a receptor for parathyroid hormone and for parathyroid hormone-related protein.

417555

Q03431.1

Q03431

66,361 Da

Class B/2 (Secretin Family Receptors) Pathway (106378); Endochondral Ossification Pathway (198812); Endocrine And Other Factor-regulated Calcium Reabsorption Pathway (213307); Endocrine And Other Factor-regulated Calcium Reabsorption Pathway (213276); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class B Secretin-like Pathway (198781); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462)

The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

PTHR: This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in PTH1R are the cause of Jansen metaphyseal chondrodysplasia (JMC). JMC is a rare autosomal dominant disorder characterized by a short-limbed dwarfism associated with hypercalcemia and normal or low serum concentrations of the two parathyroid hormones. Defects in PTH1R are the cause of chondrodysplasia Blomstrand type (BOCD). BOCD is a severe skeletal dysplasia. Defects in PTH1R may be a cause of enchondromatosis multiple (ENCHOM). Enchondromas are common benign cartilage tumors of bone. They can occur as solitary lesions or as multiple lesions in enchondromatosis (Ollier and Maffucci diseases). Clinical problems caused by enchondromas include skeletal deformity and the potential for malignant change to osteosarcoma. Defects in PTH1R are the cause of Eiken skeletal dysplasia (EISD); also known as bone modeling defect of hands and feet. It is a rare familial autosomal recessive skeletal dysplasia. It is characterized by multiple epiphyseal dysplasia, with extremely retarded ossification, principally of the epiphyses, pelvis, hands and feet, as well as by abnormal modeling of the bones in hands and feet, abnormal persistence of cartilage in the pelvis and mild growth retardation. Defects in PTH1R are a cause of primary failure of tooth eruption (PFE). PFE is a rare condition that has high penetrance and variable expressivity and in which tooth retention occurs without evidence of any obvious mechanical interference. Instead, malfunction of the eruptive mechanism itself appears to cause nonankylosed permanent teeth to fail to erupt, although the eruption pathway has been cleared by bone resorption. Belongs to the G-protein coupled receptor 2 family. Protein type: GPCR, family 2; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR. Chromosomal Location of Human Ortholog: 3p22-p21.1. Cellular Component: basolateral plasma membrane; integral to plasma membrane; brush border membrane; apical plasma membrane; cytoplasm; plasma membrane; nucleus; receptor complex. Molecular Function: protein binding; protein self-association; peptide hormone binding; parathyroid hormone receptor activity. Biological Process: cell maturation; G-protein signaling, adenylate cyclase activating pathway; bone mineralization; osteoblast development; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; negative regulation of cell proliferation; elevation of cytosolic calcium ion concentration; positive regulation of cell proliferation; chondrocyte differentiation; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); skeletal development; bone resorption; aging. Disease: Eiken Syndrome; Chondrodysplasia, Blomstrand Type; Failure Of Tooth Eruption, Primary; Metaphyseal Chondrodysplasia, Jansen Type

0.1 mg

245 USD