antibody

Anti-cardiac Troponin C antibody

MBS175730

0.1 mg

315 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, immunohistochemistry, immunohistochemistry - paraffin section

Antibody

Anti-cardiac Troponin C antibody

[cardiac Troponin C]

[Troponin C, slow skeletal and cardiac muscles; troponin C type 1(slow); tnnc1a antibody; Cardiac troponin C antibody; CMH7 antibody; cTnI antibody; slow skeletal and cardiac muscles antibody; Slow troponin C1 antibody; TN C antibody; TN-C antibody; TNC antibody; TNNC 1 antibody; TNNC antibody; TNNC1 antibody; TNNC1 protein antibody; TNNC1_HUMAN antibody; TNNI3 antibody; Troponin C antibody; Troponin C cardiac antibody; Troponin C slow antibody; Troponin C slow skeletal and cardiac muscles antibody; Troponin C type 1(slow) antibody; Troponin C type 1 antibody; Troponin C1 slow antibody; Troponin I type 3(cardiac) antibody]

[Troponin C, slow skeletal and cardiac muscles; Troponin C, slow skeletal and cardiac muscles; troponin C, slow skeletal and cardiac muscles; troponin C1, slow; cardiac troponin C; slow twitch skeletal/cardiac muscle troponin C; troponin C type 1 (slow)]

[TNNC1]

[TNNC1; TNNC1; TNC; TN-C; TNNC; CMD1Z; CMH13; TNNC; TN-C]

TNNC1_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

161

Immunogen affinity purified.

Lyophilized

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Western Blot:. Concentration:0.1-0.5ug/ml. Tested Species: Rate. Predicted Species: Hu, Ms. Immunohistochemistry (Paraffin-embedded Section):. Concentration: 0.5-1ug/ml. Tested Species: Hu, Rat. Predicted Species: Ms. Antigen Retrieval: By Heat. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Western Blot (WB)

Immunohistochemistry (IHC)

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human cardiac Troponin C (1-18aa MDDIYKAAVEQLTEEQKN), identical to the related rat and mouse sequences.

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Description: Rabbit IgG polyclonal antibody for Troponin C, slow skeletal and cardiac muscles(TNNC1) detection. Tested with WB, IHC-P in Human, Mouse, Rat. Background: Troponin C1(TNNC1)(troponin C type 1(slow)), also called TROPONIN C, SLOW-TWITCH SKELETAL MUSCLE or TNC, is a protein that in humans is encoded by the TNNC1 gene. Using a "monochromosomal" hybrid panel, the TNNC1 gene is mapped to chromosome 3; subsequent analysis of the Genebridge 4 radiation hybrid panel localized the gene to 3p in a region consistent with the earlier assignment. Circular dichroism measurements revealed changes in the secondary structures of the TNNC1 mutants A8V, C84Y, and D145E.

54042075

P63316.1

P63316

Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Cardiac Muscle Contraction Pathway (93344); Cardiac Muscle Contraction Pathway (93992); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285); Hypertrophic Cardiomyopathy (HCM) Pathway (114229); Hypertrophic Cardiomyopathy (HCM) Pathway (106591)

Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008]

TNNC1: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. Defects in TNNC1 are the cause of cardiomyopathy dilated type 1Z (CMD1Z). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in TNNC1 are the cause of familial hypertrophic cardiomyopathy type 13 (CMH13). A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Belongs to the troponin C family. Protein type: Motility/polarity/chemotaxis; Calcium-binding. Chromosomal Location of Human Ortholog: 3p21.1. Cellular Component: nucleoplasm; troponin complex; mitochondrion; cytosol; actin cytoskeleton. Molecular Function: actin filament binding; troponin T binding; protein binding; protein homodimerization activity; troponin I binding; calcium ion binding; calcium-dependent protein binding. Biological Process: regulation of ATPase activity; response to metal ion; regulation of muscle contraction; diaphragm contraction; regulation of muscle filament sliding speed; ventricular cardiac muscle morphogenesis; cardiac muscle contraction; muscle filament sliding. Disease: Cardiomyopathy, Dilated, 1z; Cardiomyopathy, Familial Hypertrophic, 13

0.1 mg

315 USD