catalog number :
MBS175712
products full name :
Anti-Arc antibody
products short name :
Arc
products name syn :
Activity-regulated cytoskeleton-associated protein; activity-regulated cytoskeleton-associated protein; activity regulated cytoskeleton associated protein antibody; activity regulated gene 3.1 protein homolog antibody; Activity-regulated cytoskeleton-associated protein antibody; Activity-regulated gene 3.1 protein homolog antibody; Arc antibody; ARC/ARG3.1 antibody; ARC_HUMAN antibody; Arg3.1 antibody
other names :
Activity-regulated cytoskeleton-associated protein; Activity-regulated cytoskeleton-associated protein; activity-regulated cytoskeleton-associated protein; ARC/ARG3.1; ARC {ECO:0000312 EMBL:AAG33705.1}; activity-regulated gene 3.1 protein homolog; activity-regulated cytoskeleton-associated protein; ARC/ARG3.1; Activity-regulated gene 3.1 protein homolog; Arg3.1
other gene names :
ARC; ARC; Arg3.1; Arg3.1
uniprot entry name :
ARC_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Immunogen affinity purified.
storage stability :
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
tested application :
Western Blot (WB)
other info1 :
Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human Arc (1-15aa MELDHRTSGGLHAYP), different from the related rat and mouse sequences by two amino acids.
other info2 :
Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
products description :
Description: Rabbit IgG polyclonal antibody for Activity-regulated cytoskeleton-associated protein(ARC) detection. Tested with WB in Human, Mouse, Rat. Background: ARC, officially called activity-regulated cytoskeleton-associated protein, is a plasticity protein first characterized in 1995. It is a member of the immediate-early gene(IEG) family. The ARC gene is mapped to chromosome 8q24. It has got 460 amino acid protein which shares significant similarity with rat Arc. The Arc is highly expressed in heart, brain, lung, skeletal muscle, pancreas, prostate and testis and has got weak expression in small intestine, colon, and peripheral blood leukocytes. Arc is widely considered to be an important protein in neurobiology and also a significant tool for systems neuroscience.
ncbi mol weight :
45,316 Da
ncbi pathways :
Amphetamine Addiction Pathway (547607); Amphetamine Addiction Pathway (550546)
uniprot summary :
ARG3.1: Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. Belongs to the ARC/ARG3.1 family. Chromosomal Location of Human Ortholog: 8q24.3. Cellular Component: postsynaptic membrane; cytoplasm; postsynaptic density; plasma membrane; dendritic spine; acrosome; cell junction; endosome; actin cytoskeleton. Biological Process: anterior/posterior pattern formation; cell migration; regulation of cell morphogenesis; cytoskeleton organization and biogenesis; endocytosis; learning; endoderm development; regulation of neuronal synaptic plasticity