Anti-IL1 beta antibody | MyBioSource MBS175705 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-IL1 beta antibody

catalog :

MBS175705

quantity :

0.1 mg

price :

280 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

mouse, rat

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

Anti-IL-1 beta antibody, MBS175705, Western blotting. Lane 1: Recombinant Mouse IL-1 beta Protein 10ng. Lane 2: Recombinant Mouse IL-1 beta Protein 5ng. Lane 3: Recombinant Mouse IL-1 beta Protein 2.5ng

product information

catalog number :

MBS175705

products type :

Antibody

products full name :

Anti-IL1 beta antibody

products short name :

[IL1 beta]

products name syn :

[Interleukin-1 beta(IL-1 beta); interleukin 1, beta; Catabolin antibody; H1 antibody; Hematopoietin 1 antibody; IFN beta inducing factor antibody; IL 1 antibody; IL 1 beta antibody; IL 1B antibody; IL-1 beta antibody; IL1 BETA antibody; IL1B antibody; IL1B_HUMAN antibody; IL1F2 antibody; Interleukin 1 beta antibody; Interleukin 1 beta precursor antibody; Interleukin-1 beta antibody; LAF antibody; OAF antibody; Osteoclast activating factor antibody; OTTHUMP00000162031 antibody; Preinterleukin 1 beta antibody; Preinterleukin beta antibody; Pro interleukin 1 beta antibody]

other names :

[Interleukin-1 beta; Interleukin-1 beta; interleukin-1 beta; IL-1 beta; interleukin 1 beta]

products gene name :

[IL1B]

other gene names :

[Il1b; Il1b; Il-1b; IL-1beta; IL-1 beta]

uniprot entry name :

IL1B_MOUSE

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Mouse, Rat

sequence length :

269

specificity :

No cross reactivity with other proteins.

purity :

Immunogen affinity purified.

form :

Lyophilized

concentration :

200ug/ml

storage stability :

At -20 degree C for one year. After reconsitution at 4 degree C for one month. It can also be aliquotted and store frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB)

app notes :

Western blot. Concentration: 0.1-0.5ug/ml. Tested Species: Ms, Rat. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

image1 heading :

Western Blot (WB)

other info1 :

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of mouse IL1 beta (250-265aa FLGNNSGQDIIDFTME), different from the related rat sequence by four amino acids.

other info2 :

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na 2 HPO 4 , 0.05mg Thimersol, 0.05mg NaN 3 . Reconstitution: 0.2ml of distilled water will yield a concentration of 500ug/ml

products description :

Description: Rabbit IgG polyclonal antibody for Interleukin-1 beta(IL1B) detection. Tested with WB in Mouse, Rat. Background: Interleukin-1 beta(IL-1beta) also know as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene, which localizes to the long arm of chromosome at position 2q13-2q21 between two fragile sites. Interleukin 1(IL-1) is a protein with several biological activities regulating host defense and immune responses.2 The human IL-1 family plays an important role in the pathogenesis of many diseases and functions as a key mediator of the host response to various infectious, inflammatory, and immunologic challenges.

ncbi gi num :

124304

ncbi acc num :

P10749.1

uniprot acc num :

P10749

ncbi mol weight :

30,931 Da

ncbi pathways :

African Trypanosomiasis Pathway (194387); African Trypanosomiasis Pathway (194323); Alzheimer's Disease Pathway (83294); Alzheimer's Disease Pathway (509); Amoebiasis Pathway (167330); Amoebiasis Pathway (167191); Apoptosis Pathway (83257); Apoptosis Pathway (470); Chagas Disease (American Trypanosomiasis) Pathway (147810); Chagas Disease (American Trypanosomiasis) Pathway (147795)

ncbi summary :

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1. The encoded protein plays a role in thymocyte proliferation and is involved in the inflammatory response. [provided by RefSeq, Aug 2015]

uniprot summary :

IL1B: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. Monomer. Belongs to the IL-1 family. Protein type: Cytokine. Cellular Component: extracellular space; cell; extracellular region; intracellular; cytosol; vesicle; secretory granule. Molecular Function: protein domain specific binding; interleukin-1 receptor binding; cytokine activity; receptor binding. Biological Process: positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of JNK activity; negative regulation of MAP kinase activity; positive regulation of nitric oxide biosynthetic process; negative regulation of glutamate secretion; activation of MAPK activity; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; positive regulation of interleukin-2 biosynthetic process; germ cell programmed cell death; negative regulation of insulin receptor signaling pathway; positive regulation of glial cell differentiation; positive regulation of lipid catabolic process; positive regulation of NF-kappaB import into nucleus; response to lipopolysaccharide; fever; positive regulation of membrane protein ectodomain proteolysis; response to carbohydrate stimulus; activation of NF-kappaB transcription factor; elevation of cytosolic calcium ion concentration; positive regulation of phagocytosis; positive regulation of T cell proliferation; positive regulation of astrocyte differentiation; neutrophil chemotaxis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of heterotypic cell-cell adhesion; positive regulation of mitosis; positive regulation of interleukin-6 production; interleukin-1 beta production; social behavior; positive regulation of angiogenesis; negative regulation of neuron differentiation; positive regulation of cell division; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; negative regulation of lipid metabolic process; leukocyte migration; sequestering of triacylglycerol; positive regulation of interleukin-6 biosynthetic process; positive regulation of JNK cascade; negative regulation of transcription from RNA polymerase II promoter; positive regulation of stress-activated MAPK cascade; negative regulation of neurogenesis; positive regulation of interleukin-8 production; negative regulation of cell proliferation; negative regulation of lipid catabolic process; hyaluronan biosynthetic process; lipopolysaccharide-mediated signaling pathway; protein kinase B signaling cascade; regulation of I-kappaB kinase/NF-kappaB cascade; inflammatory response; aging; cytokine and chemokine mediated signaling pathway; MAPKKK cascade; positive regulation of immature T cell proliferation in the thymus; response to ATP; memory; positive regulation of interferon-gamma production; positive regulation of chemokine biosynthetic process; positive regulation of prostaglandin secretion; positive regulation of fever; immune response; positive regulation of protein amino acid phosphorylation; regulation of insulin secretion

size1 :

0.1 mg

price1 :

280 USD

more info or order :

MyBioSource product webpage