Anti-Kallikrein 6 antibody | MyBioSource MBS175702 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-Kallikrein 6 antibody

catalog :

MBS175702

quantity :

0.1 mg

price :

245 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS175702

products type :

Antibody

products full name :

Anti-Kallikrein 6 antibody

products short name :

Kallikrein 6

products name syn :

Kallikrein-6; kallikrein-related peptidase 6; Bssp antibody; hK 6 antibody; hK6 antibody; Kallikrein 6 precursor antibody; Kallikrein related peptidase 6 antibody; Kallikrein-6 antibody; Kallikrein6 antibody; KLK 6 antibody; Klk 7 antibody; KLK 9 antibody; Klk29 antibody; Klk6 antibody; KLK6_HUMAN antibody; Klk7 antibody; KLK9 antibody; MGC9355 antibody; mGK 1 antibody; mGK1 antibody; MSP antibody; Neurosin antibody; Protease M antibody; Protease serine 18 antibody; Protease serine 9 antibody; PRSS 18 antibody; PRSS 9 antibody; PRSS18 antibody; PRSS9 antibody; Serine protease 18 antibody; Serine protease 9 antibody; SP 59 antibody; SP59 antibody; Tissue kallikrein antibody; TK antibody; Zyme antibody

other names :

Kallikrein-6; Kallikrein-6; kallikrein-6; zyme; neurosin; protease M; serine protease 9; serine protease 18; kallikrein-related peptidase 6; Neurosin; Protease M; SP59; Serine protease 18; Serine protease 9; Zyme

products gene name :

KLK6

other gene names :

KLK6; KLK6; hK6; Bssp; Klk7; SP59; PRSS9; PRSS18; PRSS18; PRSS9

uniprot entry name :

KLK6_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

244

purity :

Immunogen affinity purified.

form :

Lyophilized

storage stability :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC)

app notes :

Western Blot (WB):. Concentration: 0.1-0.5ug/ml. Tested Species: Hu. Predicted Species: n/a. Antigen Retrieval: n/a . Immunohistrochemistry IHC) - Paraffin-embedded Section: Concentration: 0.5-1ug/ml. Tested Species: Hu. Predicted Species: n/a. Antigen Retrieval: By Heat. Immunocytochemistry (ICC): Concentration: 0.5-1ug/ml. Tested Species: Hu. Predicted Species: n/a. Antigen Retrieval: n/a . Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

other info1 :

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Kallikrein 6 (227-244aa YTNVCRYTNWIQKTIQAK).

other info2 :

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

products description :

Description: Rabbit IgG polyclonal antibody for Kallikrein-6(KLK6) detection. Tested with WB, IHC-P, ICC in Human. Background: KLK6(Kallikrein-related peptidase 6), also called KALLIKREIN 6, NEUROSIN, PROTEASE M, ZYME or PRSS9, is a protein that in humans is encoded by the KLK6 gene. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. Northern blot analysis revealed that the PRSS9 mRNA was expressed in several primary tumors and cell lines from mammary, prostate, and ovarian cancers, but was not detected in any metastases of these cancers. The KLK6 gene is mapped on 19q13.41. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Upon cellular stress, neurosin was released from mitochondria to the cytosol, which resulted in the increase of degraded alpha-synuclein species. Neurosin may play a significant role in physiologic alpha-synuclein degradation and also in the pathogenesis of synucleinopathies.

ncbi gi num :

3914480

ncbi acc num :

Q92876.1

uniprot acc num :

Q92876

ncbi mol weight :

4,333 Da

ncbi pathways :

Alpha-synuclein Signaling Pathway (137913)

ncbi summary :

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

KLK6: Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis. Belongs to the peptidase S1 family. Kallikrein subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Protease; Secreted; EC 3.4.21.-; Secreted, signal peptide; Nucleolus. Chromosomal Location of Human Ortholog: 19q13.3. Cellular Component: microtubule cytoskeleton; nucleoplasm; extracellular space; intercellular bridge; nuclear membrane; mitochondrion; endoplasmic reticulum; cytoplasm; extracellular region; nucleolus. Molecular Function: protein binding; serine-type endopeptidase activity. Biological Process: myelination; collagen catabolic process; protein autoprocessing; central nervous system development; tissue regeneration; amyloid precursor protein metabolic process; positive regulation of G-protein coupled receptor protein signaling pathway; regulation of cell differentiation; response to wounding; hormone metabolic process; protein processing; proteolysis

size1 :

0.1 mg

price1 :

245 USD

more info or order :

MyBioSource product webpage