antibody

Anti-Neurokinin 1 Receptor antibody

MBS175655

0.1 mg

245 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

Antibody

Anti-Neurokinin 1 Receptor antibody

Neurokinin 1 Receptor

Substance-P receptor(SPR); tachykinin receptor 1; neurokinin 1 antibody; NK 1 receptor antibody; NK 1R antibody; NK-1 receptor antibody; NK-1R antibody; NK1 receptor antibody; NK1R antibody; NK1R_HUMAN antibody; NKIR antibody; SPR antibody; Substance P receptor antibody; Substance-P receptor antibody; TAC 1R antibody; TAC1R antibody; Tachykinin 1 receptor(substance P receptor neurokinin 1 receptor) antibody; Tachykinin receptor 1 antibody; Tachykinin receptor 1(substance P receptor neurokinin 1 receptor) antibody; TACR1 antibody

Substance-P receptor; Substance-P receptor; substance-P receptor; NK-1R; NK-1 receptor; tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor); tachykinin receptor 1; NK-1 receptor; NK-1R; Tachykinin receptor 1

TACR1

TACR1; TACR1; SPR; NK1R; NKIR; TAC1R; NK1R; TAC1R; SPR; NK-1R

NK1R_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

407

Immunogen affinity purified.

Lyophilized

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Western Blot (WB)

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human Neurokinin 1 Receptor (231-245aa DSSDRYHEQVSAKRK), identical to the related rat and mouse sequences.

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Description: Rabbit IgG polyclonal antibody for Substance-P receptor(TACR1) detection. Tested with WB in Human, Mouse, Rat. Background: The tachykinin receptor 1(TACR1) also known as neurokinin 1 receptor(NK1R) or substance P receptor(SPR) is a G protein coupled receptor found in the central nervous system and peripheral nervous system. The endogenous ligand for this receptor is Substance P, although it has some affinity for other tachykinins. The protein is the product of the TACR1 gene. Tachykinin receptor 1 consists of 407 amino acid residues, and it has a molecular weight of 58.000. Tachykinin receptor 1, as well as the other tachykinin receptors, is made of seven hydrophobic transmembrane(TM) domains with three extracellular and three intracellular loops, an amino-terminus and a cytoplasmic carboxy-terminus. The loops have functional sites, including two cysteines amino acids for a disulfide bridge, Asp-Arg-Tyr, which is responsible for association with arrestin and, Lys/Arg-Lys/Arg-X-X-Lys/Arg, which interacts with G-proteins.The tachykinin receptor 1 can be found in both the central and peripheral nervous system. It is present in neurons, brainstem, vascular endothelial cells, muscle, gastrointestinal tracts, genitourinary tract, pulmonary tissue, thyroid gland and different types of immune cells. The binding of SP to the tachykinin receptor 1 has been associated with the transmission of stress signals and pain, the contraction of smooth muscles and inflammation. Tachykinin receptor 1 antagonists have also been studied in migraine, emesis and psychiatric disorders. In fact, aprepitant has been proved effective in a number of pathophysiological models of anxiety and depression. Other diseases in which the tachykinin receptor 1 system is involved include asthma, rheumatoid arthritis and gastrointestinal disorders.

128359

P25103.1

P25103

35,713 Da

Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Gastrin-CREB Signalling Pathway Via PKC And MAPK (645295); Measles Pathway (213306); Measles Pathway (213277); Neuroactive Ligand-receptor Interaction Pathway (83053)

This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008]

TACR1: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P substance K neuromedin-K. Belongs to the G-protein coupled receptor 1 family. Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1. Chromosomal Location of Human Ortholog: 2p12. Cellular Component: cell surface; integral to plasma membrane; cytoplasm; dendrite; plasma membrane. Molecular Function: protein binding; substance P receptor activity; tachykinin receptor activity. Biological Process: response to nicotine; tachykinin signaling pathway; positive regulation of leukocyte migration; response to morphine; positive regulation of saliva secretion; response to estradiol stimulus; elevation of cytosolic calcium ion concentration; behavioral response to pain; regulation of smooth muscle cell migration; positive regulation of lymphocyte proliferation; positive regulation of stress fiber formation; positive regulation of action potential; inflammatory response; response to electrical stimulus; angiotensin mediated drinking behavior; associative learning; detection of abiotic stimulus; positive regulation of synaptic transmission, cholinergic; regulation of smooth muscle cell proliferation; eating behavior; positive regulation of synaptic transmission, GABAergic; positive regulation of hormone secretion; positive regulation of ossification; positive regulation of vascular permeability; response to ethanol; long-term memory; smooth muscle contraction involved in micturition; response to heat; response to ozone; operant conditioning; positive regulation of vasoconstriction; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); sperm ejaculation; response to progesterone stimulus; acute inflammatory response; positive regulation of blood pressure; positive regulation of epithelial cell proliferation

0.1 mg

245 USD