Anti-Integrin alpha 3 antibody | MyBioSource MBS175637 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-Integrin alpha 3 antibody

catalog :

MBS175637

quantity :

0.1 mg

price :

245 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS175637

products type :

Antibody

products full name :

Anti-Integrin alpha 3 antibody

products short name :

Integrin alpha 3

products name syn :

Integrin alpha-3; integrin, alpha 3(antigen CD49C, alpha 3 subunit of VLA-3 receptor); AA407068 antibody; Antigen identified by monoclonal antibody J143 antibody; CD49 antigen like family member C antibody; CD49 antigen-like family member C antibody; CD49c antibody; CD49c antigen antibody; FLJ34631 antibody; FLJ34704 antibody; FRP 2 antibody; FRP-2 antibody; FRP2 antibody; galactoprotein B3 antibody; GAP B3 antibody; GAPB3 antibody; Integrin alpha 3 antibody; Integrin alpha-3 light chain antibody; Integrin, alpha 3(antigen CD49C, alpha 3 subunit of VLA-3 receptor) antibody; ITA3_HUMAN antibody; ITGA 3 antibody; ITGA3 antibody; MSK18 antibody; URO1 antibody; VCA 2 antibody; VCA2 antibody; Very late activation protein 3 receptor alpha 3 subunit antibody; Very Late Activation Protein 3 Receptor Alpha 3 Subunit antibody; VL3A antibody; VLA 3 alpha chain antibody; VLA 3 subunit alpha antibody; VLA-3 subunit alpha antibody; VLA3 antibody; VLA3a antibody

other names :

Integrin alpha-3; Integrin alpha-3; integrin alpha-3; FRP-2; galactoprotein B3; VLA-3 subunit alpha; CD49 antigen-like family member C; antigen identified by monoclonal antibody J143; very late activation protein 3 receptor, alpha-3 subunit; integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor); CD49 antigen-like family member C; FRP-2; Galactoprotein B3; GAPB3; VLA-3 subunit alpha; CD_antigen: CD49cCleaved into the following 2 chains:Integrin alpha-3 heavy chain; Integrin alpha-3 light chain

products gene name :

ITGA3

other gene names :

ITGA3; ITGA3; VL3A; CD49C; GAPB3; ILNEB; MSK18; VCA-2; VLA3a; GAP-B3; MSK18; GAPB3

uniprot entry name :

ITA3_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

1051

purity :

Immunogen affinity purified.

form :

Lyophilized

storage stability :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

other info1 :

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human Integrin alpha 3 (51-67aa LFGYSVALHRQTERQQR), identical to the related rat and mouse sequences.

other info2 :

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

products description :

Description: Rabbit IgG polyclonal antibody for Integrin alpha-3(ITGA3) detection. Tested with WB, IHC-P in Human, Mouse, Rat. Background: ITGA3(INTEGRIN, ALPHA-3), also called CD49C, VLA3 or GAPB3, is a protein that in humans is encoded by the ITGA3 gene. ITGA3 is an integrin alpha subunit which is also a member of the family of cell surface adhesion molecules. ITGA3 is mapped to chromosome 17 and its exact cytogenetic location is 17q21.33. ITGA3 makes up half of the alpha3beta1 integrin duplex that plays a role in neural migration and corticogenesis together with beta-1 subunit. A functional link between DAB1 phosphorylation and ITGA3 signaling drives the timely detachment of migrating neurons from radial glial fibers. Expression of human ITGA3 increased the infectivity of virus for Chinese hamster ovary cells. ITGA3 also contains 13 potential N-glycosylation sites, 2 potential cleavage sites, and the 7 N-terminal repeating units characteristic of ITGAs. Recombinant ITGA3 is expressed as a 150-kD protein as the same size as the native protein by the western blot analysis.

ncbi gi num :

347595830

ncbi acc num :

P26006.5

uniprot acc num :

P26006

ncbi mol weight :

118,756 Da

ncbi pathways :

Arf6 Trafficking Events Pathway (137954); Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Basigin Interactions Pathway (106065); CXCR4-mediated Signaling Events Pathway (137910); Cell Surface Interactions At The Vascular Wall Pathway (106062); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285); ECM-receptor Interaction Pathway (83068)

ncbi summary :

The protein encoded by this gene belongs to the family of integrins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain, and function as cell surface adhesion molecules. This gene encodes alpha 3 subunit, which undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 subunit to form an integrin that interacts with many extracellular-matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]

uniprot summary :

ITGA3: an integral membrane protein that heterodimerizes with a beta chain, forming a receptor for many extracellular-matrix proteins including fibronectin, laminin, collagen, epiligrin and thrombospondin. Undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1. Two alternatively spliced isoforms have been described. Protein type: Motility/polarity/chemotaxis; Receptor, misc.; Cell adhesion; Membrane protein, integral. Chromosomal Location of Human Ortholog: 17q21.33. Cellular Component: filopodium membrane; cell surface; focal adhesion; growth cone; basolateral plasma membrane; perinuclear region of cytoplasm; plasma membrane; excitatory synapse; integrin complex; receptor complex; external side of plasma membrane. Molecular Function: collagen binding; integrin binding; protein domain specific binding; protein binding; protease binding; protein heterodimerization activity; fibronectin binding; metal ion binding; laminin binding; glycoprotein binding. Biological Process: integrin-mediated signaling pathway; skin development; response to drug; extracellular matrix organization and biogenesis; maternal process involved in pregnancy; heart development; cell-matrix adhesion; regulation of BMP signaling pathway; neuron migration; regulation of Wnt receptor signaling pathway; mesodermal cell differentiation; memory; regulation of transforming growth factor beta receptor signaling pathway; negative regulation of Rho protein signal transduction; blood coagulation; leukocyte migration; negative regulation of cell projection organization and biogenesis; lung development. Disease: Interstitial Lung Disease, Nephrotic Syndrome, And Epidermolysis Bullosa, Congenital

size1 :

0.1 mg

price1 :

245 USD

more info or order :

MyBioSource product webpage