Anti-Progesterone Receptor antibody | MyBioSource MBS175575 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-Progesterone Receptor antibody

catalog :

MBS175575

quantity :

0.1 mg

price :

245 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS175575

products type :

Antibody

products full name :

Anti-Progesterone Receptor antibody

products short name :

Progesterone Receptor

products name syn :

Progesterone receptor(PR); progesterone receptor; NR3C3 antibody; Nuclear receptor subfamily 3 group C member 3 antibody; PGR antibody; PR antibody; PRA antibody; PRB antibody; PRGR_HUMAN antibody; Progesterone receptor antibody; Progestin receptor form A antibody; Progestin receptor form B antibody

other names :

Progesterone receptor; Progesterone receptor; progesterone receptor; nuclear receptor subfamily 3 group C member 3; progesterone receptor; Nuclear receptor subfamily 3 group C member 3

products gene name :

PGR

other gene names :

PGR; PGR; PR; NR3C3; NR3C3; PR

uniprot entry name :

PRGR_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

933

purity :

Immunogen affinity purified.

form :

Lyophilized

storage stability :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

other info1 :

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human Progesterone Receptor (536-553aa QVYPPYLNYLRPDSEASQ), identical to the related rat and mouse sesquences.

other info2 :

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

products description :

Description: Rabbit IgG polyclonal antibody for Progesterone receptor(PGR) detection. Tested with WB, IHC-P in Human, Mouse, Rat. Background: The progesterone receptor(PR) is an intracellular steroid receptor that specially binds progesterone in humans. PR has been a member of the steroid receptor superfamily. It is encoded by a single PGR gene residing on chromosome 11q22. The PGR gene uses separate promoters and translational start sites to produce 2 isoforms, PRA and PRB, which are identical except for an additional 165 amino acids present only in the N terminus of PRB. It can be observed in human breast tissues. The proteins function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner.

ncbi gi num :

90110048

ncbi acc num :

P06401.4

uniprot acc num :

P06401

ncbi mol weight :

87,747 Da

ncbi pathways :

Cellular Roles Of Anthrax Toxin Pathway (138076); Gene Expression Pathway (105937); Generic Transcription Pathway (105938); Nuclear Receptor Transcription Pathway (105979); Nuclear Receptors Pathway (198848); Nuclear Signaling By ERBB4 Pathway (530744); Oocyte Meiosis Pathway (126909); Oocyte Meiosis Pathway (126872); Ovarian Infertility Genes Pathway (198801); Progesterone-mediated Oocyte Maturation Pathway (119304)

ncbi summary :

This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Jan 2011]

uniprot summary :

PR: a nuclear hormone receptor and transcription factor. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Two splice-variant isoforms have been described. Protein type: DNA-binding; Nuclear receptor. Chromosomal Location of Human Ortholog: 11q22-q23. Cellular Component: nucleoplasm; mitochondrial outer membrane. Molecular Function: ligand-dependent nuclear receptor activity; protein binding; enzyme binding; DNA binding; zinc ion binding; steroid hormone receptor activity; steroid binding; receptor binding. Biological Process: transcription initiation from RNA polymerase II promoter; progesterone receptor signaling pathway; cell-cell signaling; epithelial cell maturation; gene expression; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; ovulation from ovarian follicle; signal transduction; regulation of epithelial cell proliferation. Disease: Progesterone Resistance

size1 :

0.1 mg

price1 :

245 USD

more info or order :

MyBioSource product webpage