Anti-GRO alpha antibody | MyBioSource MBS175526 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-GRO alpha antibody

catalog :

MBS175526

quantity :

0.1 mg

price :

280 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

Anti-GRO alpha antibody, MBS175526, Western blotting. All lanes: Anti GRO alpha (MBS175526) at 0.5ug/ml. Lane 1: HELA Whole Cell Lysate at 40ug. Lane 2: JURKAT Whole Cell Lysate at 40ug. Predicted bind size: 11KD. Observed bind size: 11KD

product information

catalog number :

MBS175526

products type :

Antibody

products full name :

Anti-GRO alpha antibody

products short name :

[GRO alpha]

products name syn :

[Growth-regulated alpha protein; chemokine(C-X-C motif) ligand 1(melanoma growth stimulating activity, alpha); C-X-C motif chemokine 1 antibody; Chemokine(C X C motif) ligand 1 antibody; Chemokine(C-X-C motif) ligand 1(melanoma growth stimulating activity, alpha) antibody; chemokine(C-X-C motif) ligand 1 antibody; Chemokine ligand 1 antibody; CINC-1 antibody; Cxcl 1 antibody; Cxcl1 antibody; Cytokine-induced neutrophil chemoattractant 1 antibody; Fibroblast secretory protein antibody; Fsp antibody; Gro 1 antibody; Gro A antibody; GRO alpha antibody; GRO antibody; GRO protein, alpha antibody; GRO-alpha(1-73) antibody; GRO-alpha(6-73) antibody; Gro1 antibody; GRO1 oncogene(melanoma growth stimulating activity, alpha) antibody; GRO1 oncogene(melanoma growth-stimulating activity) antibody; Gro1 oncogene antibody; GroA antibody; GROA_HUMAN antibody; Growth regulated protein alpha antibody; Growth regulated protein GRO antibody; KC antibody; KC chemokine, mouse, homolog of antibody; Melanoma growth stimulatory activity alpha antibody; Melanoma growth stimulatory activity antibody; Melanoma growth stimulatory activity, alpha antibody; MGSA a antibody; MGSA alpha antibody; MGSA antibody; MGSA-a antibody; N51 antibody; NAP 3 antibody; NAP-3 antibody; NAP3 antibody; Neutrophil activating protein 3 antibody; Neutrophil-activating protein 3 antibody; Platelet-derived growth factor-inducible protein KC antibody; Scyb 1 antibody; SCYB1 antibody; Secretory protein N51 antibody; Small inducible cytokine subfamily B, member 1 antibody]

other names :

[Growth-regulated alpha protein; Growth-regulated alpha protein; growth-regulated alpha protein; MGSA alpha; GRO-alpha(1-73); C-X-C motif chemokine 1; fibroblast secretory protein; neutrophil-activating protein 3; melanoma growth stimulatory activity alpha; GRO1 oncogene (melanoma growth-stimulating activity); GRO1 oncogene (melanoma growth stimulating activity, alpha); chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); C-X-C motif chemokine 1; GRO-alpha(1-73); Melanoma growth stimulatory activity; MGSA; Neutrophil-activating protein 3; NAP-3]

products gene name :

[CXCL1]

other gene names :

[CXCL1; CXCL1; FSP; GRO1; GROa; MGSA; NAP-3; SCYB1; MGSA-a; GRO; GRO1; GROA; MGSA; SCYB1; MGSA; NAP-3]

uniprot entry name :

GROA_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

107

specificity :

No cross reactivity with other proteins.

purity :

Immunogen affinity purified.

form :

Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

storage stability :

At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB)

app notes :

Western Blot . Concentration: 0.1-0.5 ug/mL. Tested Species: Human . Tested Species: In-tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

image1 heading :

Western Blot (WB)

other info1 :

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human GRO alpha (99-107aa KMLNSDKSN).

other info2 :

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

products description :

Description: Rabbit IgG polyclonal antibody for Growth-regulated alpha protein(CXCL1) detection. Tested with WB in Human. Background: CXCL1(Chemokine, CXC motif, Ligand 1), also called GRO1, SCYB1, GROA or MGSA, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GROalpha, KC, Neutrophil-activating protein 3(NAP-3) and melanoma growth stimulating activity, alpha(MSGA-alpha). In humans, this protein is encoded by the CXCL1 gene. The CXCL1 gene is mapped on 4q13.3. CXCL1 is secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis. CXCL1 is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil chemoattractant activity. CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation,wound healing, and tumorigenesis. Signaling through Cxcr2, Cxcl1 inhibited oligodendrocyte precursor migration. The migrational arrest was rapid, reversible, and concentration dependent, and it reflected enhanced cell/substrate interactions. White matter expression of Cxcl1 was temporospatially regulated. Others contribute to aggressive growth selectivity in the lung. Among the lung metastasis signature genes identified, several, including CXCL1, were functionally validated.

ncbi gi num :

121622

ncbi acc num :

P09341.1

uniprot acc num :

P09341

ncbi pathways :

Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Cytokines And Inflammatory Response Pathway (198794); Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway (83102)

ncbi summary :

This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014]

uniprot summary :

CXCL1: Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO- alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity. Belongs to the intercrine alpha (chemokine CxC) family. Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 4q21. Cellular Component: extracellular space; extracellular region. Molecular Function: growth factor activity; chemokine activity; CXCR chemokine receptor binding; enzyme activator activity; receptor binding. Biological Process: positive regulation of catalytic activity; G-protein coupled receptor protein signaling pathway; cell proliferation; nervous system development; negative regulation of cell proliferation; immune response; response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; inflammatory response; actin cytoskeleton organization and biogenesis; chemotaxis; signal transduction

size1 :

0.1 mg

price1 :

280 USD

more info or order :

MyBioSource product webpage