Anti-Lamin B1 antibody | MyBioSource MBS175517 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-Lamin B1 antibody

catalog :

MBS175517

quantity :

0.1 mg

price :

245 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS175517

products type :

Antibody

products full name :

Anti-Lamin B1 antibody

products short name :

Lamin B1

products name syn :

Lamin-B1; lamin B1; ADLD antibody; lamin B1 antibody; Lamin-B1 antibody; LMN antibody; LMN2 antibody; LMNB antibody; Lmnb1 antibody; LMNB1_HUMAN antibody; MGC111419 antibody; OTTHUMP00000159218 antibody

other names :

Lamin-B1; Lamin-B1; lamin-B1; lamin B1

products gene name :

LMNB1

other gene names :

LMNB1; LMNB1; LMN; ADLD; LMN2; LMNB; LMN2; LMNB

uniprot entry name :

LMNB1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Rat

sequence length :

586

purity :

Immunogen affinity purified.

form :

Lyophilized

storage stability :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunohistochemistry (IHC) Formalin, Immunocytochemistry ICC

other info1 :

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Lamin B1 (570-586aa FHQQGTPRASNRSCAIM), different from the related rat sequence by one amino acid, and from the related mouse sequence by three amino acids.

other info2 :

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

products description :

Description: Rabbit IgG polyclonal antibody for Lamin-B1(LMNB1) detection. Tested with WB, IHC-P, IHC-F, ICC in Human, Rat. Background: Lamin-B1 is a protein that in humans is encoded by the LMNB1 gene. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are though to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1.

ncbi gi num :

125953

ncbi acc num :

P20700.2

uniprot acc num :

P20700

ncbi mol weight :

66,408 Da

ncbi pathways :

Apoptosis Pathway (105648); Apoptotic Cleavage Of Cellular Proteins Pathway (105678); Apoptotic Execution Phase Pathway (105677); Breakdown Of The Nuclear Lamina Pathway (105681); Caspase Cascade In Apoptosis Pathway (137974); Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); Cellular Senescence Pathway (905991); Cellular Responses To Stress Pathway (645258); DNA Damage/Telomere Stress Induced Senescence Pathway (905994)

ncbi summary :

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). [provided by RefSeq, Oct 2010]

uniprot summary :

Lamin B1: nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. B-type lamins are phosphorylated within minutes of engaging the IgM surface receptor of resting splenic B cells. Nuclear lamins are cleaved by caspases during apoptosis. Protein type: Cytoskeletal. Chromosomal Location of Human Ortholog: 5q23.2. Cellular Component: nucleoplasm; nuclear membrane; membrane; lamin filament; nuclear inner membrane; nuclear envelope. Molecular Function: phospholipase binding; structural molecule activity. Biological Process: apoptosis; cell structure disassembly during apoptosis. Disease: Leukodystrophy, Demyelinating, Adult-onset, Autosomal Dominant

size1 :

0.1 mg

price1 :

245 USD

more info or order :

MyBioSource product webpage