antibody

Anti-IP10 antibody

MBS175477

0.1 mg

245 USD

polyclonal

rabbit

nonconjugated

western blot, immunohistochemistry, immunohistochemistry - paraffin section

Antibody

Anti-IP10 antibody

IP10

C-X-C motif chemokine 10; chemokine(C-X-C motif) ligand 10; 10 kDa interferon gamma induced protein antibody; 10 kDa interferon gamma-induced protein antibody; C X C motif chemokine 10 antibody; C7 antibody; Chemokine(C X C motif) ligand 10 antibody; Chemokine CXC motif ligand 10 antibody; Crg 2 antibody; CRG2 antibody; CXCL 10 antibody; CXCL10 antibody; CXCL10(1-73) antibody; CXL10_HUMAN antibody; Gamma IP10 antibody; Gamma-IP10 antibody; gIP 10 antibody; GIP10 antibody; IFI 10 antibody; IFI10 antibody; INP 10 antibody; INP10 antibody; Interferon activated gene 10 antibody; Interferon gamma induced cell line antibody; Interferon inducible cytokine IP 10 antibody; Interferon inducible cytokine IP10 antibody; IP 10 antibody; IP-10 antibody; Mob 1 antibody; MOB1 antibody; Protein 10 from interferon(gamma) induced cell line antibody; SCYB 10 antibody; SCYB10 antibody; Small inducible cytokine B10 antibody; Small inducible cytokine B10 precursor antibody; Small inducible cytokine subfamily B(Cys X Cys) member 10 antibody; Small inducible cytokine subfamily B CXC member 10 antibody; Small-inducible cytokine B10 antibody

C-X-C motif chemokine 10; C-X-C motif chemokine 10; C-X-C motif chemokine 10; gamma IP10; gamma-IP10; small-inducible cytokine B10; interferon-inducible cytokine IP-10; 10 kDa interferon gamma-induced protein; protein 10 from interferon (gamma)-induced cell line; small inducible cytokine subfamily B (Cys-X-Cys), member 10; chemokine (C-X-C motif) ligand 10; 10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; Small-inducible cytokine B10Cleaved into the following chain:CXCL10(1-73)

CXCL10

CXCL10; CXCL10; C7; IFI10; INP10; IP-10; crg-2; mob-1; SCYB10; gIP-10; INP10; SCYB10; Gamma-IP10; IP-10

CXL10_HUMAN

Polyclonal

IgG

Rabbit

Human

98

Immunogen affinity purified.

Lyophilized

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human IP10 (79-98aa SKAIKNLLKAVSKERSKRSP).

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Description: Rabbit IgG polyclonal antibody for C-X-C motif chemokine 10(CXCL10) detection. Tested with WB, IHC-P in Human. Background: C-X-C motif chemokine 10(CXCL10), also known as Interferon gamma-induced protein 10 kDa(IP-10) or small-inducible cytokine B10, is a protein that in humans is encoded by the CXCL10 gene. It is a small cytokine belonging to the CXC chemokine family. The gene for CXCL10 is located on human chromosome 4 in a cluster among several other CXC chemokines. Luster et al.(1987) reported the isolation of an interferon-inducible gene that encodes a 98-amino acid protein called IP10. The chemokine IFN-gamma-inducible protein 10(IP-10; CXCL10), a CXC chemokine, and its receptor, CXCR3, were found to be overexpressed in lymph node cells of EAMG rats. IP10 inhibits bone marrow colony formation, has antitumor activity in vivo, is a chemoattractant for human monocytes and T cells, and promotes T cell adhesion to endothelial cells.

21542456

P02778.2

P02778

10,881 Da

CXCR3-mediated Signaling Events Pathway (138011); Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Cytosolic DNA-sensing Pathway (125137); Cytosolic DNA-sensing Pathway (124833); G Alpha (i) Signalling Events Pathway (119550)

This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014]

CXCL10: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3. Belongs to the intercrine alpha (chemokine CxC) family. Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis; Chemokine. Chromosomal Location of Human Ortholog: 4q21. Cellular Component: extracellular space; extracellular region; external side of plasma membrane. Molecular Function: heparin binding; protein binding; CXCR3 chemokine receptor binding; chemokine activity; cAMP-dependent protein kinase regulator activity; receptor binding. Biological Process: muscle development; blood circulation; protein secretion; positive regulation of leukocyte chemotaxis; positive regulation of cAMP metabolic process; signal transduction; chemotaxis; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; cell surface receptor linked signal transduction; response to vitamin D; cell-cell signaling; positive regulation of cell proliferation; response to gamma radiation; positive regulation of transcription from RNA polymerase II promoter; immune response; response to cold; positive regulation of release of sequestered calcium ion into cytosol; regulation of protein kinase activity; inflammatory response; negative regulation of myoblast differentiation; defense response to virus

0.1 mg

245 USD