Anti-SNRPN antibody | MyBioSource MBS175473 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-SNRPN antibody

catalog :

MBS175473

quantity :

0.1 mg

price :

245 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS175473

products type :

Antibody

products full name :

Anti-SNRPN antibody

products short name :

SNRPN

products name syn :

Small nuclear ribonucleoprotein-associated protein N(snRNP-N); small nuclear ribonucleoprotein polypeptide N; HCERN3 antibody; PWCR antibody; RSMN_HUMAN antibody; RT LI antibody; RTLI antibody; SM D antibody; Sm N antibody; Sm protein D antibody; Sm protein N antibody; Sm-D antibody; Sm-N antibody; Small nuclear ribonucleoprotein associated protein N antibody; Small nuclear ribonucleoprotein polypeptide N antibody; Small nuclear ribonucleoprotein-associated protein N antibody; SMD antibody; SmN antibody; SNRNP N antibody; snRNP-N antibody; SNRNPN antibody; SNRPN antibody; SNURF SNRPN antibody; Tissue specific splicing protein antibody; Tissue-specific-splicing protein antibody

other names :

Small nuclear ribonucleoprotein-associated protein N; Small nuclear ribonucleoprotein-associated protein N; small nuclear ribonucleoprotein-associated protein N; SM protein N; sm protein D; tissue-specific splicing protein; small nuclear ribonucleoprotein polypeptide N; Sm protein D; Sm-D; Sm protein N; Sm-N; SmN; Tissue-specific-splicing protein

products gene name :

SNRPN

other gene names :

SNRPN; SNRPN; SMN; PWCR; SM-D; sm-N; RT-LI; HCERN3; SNRNP-N; SNURF-SNRPN; HCERN3; SMN; snRNP-N; Sm-D; Sm-N; SmN

uniprot entry name :

RSMN_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

240

purity :

Immunogen affinity purified.

form :

Lyophilized

storage stability :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC)

other info1 :

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human SNRPN (31-48aa FKAFDKHMNLILCDCDEF), identical to the related rat and mouse sequences.

other info2 :

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

products description :

Description: Rabbit IgG polyclonal antibody for Small nuclear ribonucleoprotein-associated protein N(SNRPN) detection. Tested with WB, IHC-P, ICC in Human, Mouse, Rat. Background: SNRPN(Small Nuclear Ribonucleoprotein Polypeptide N), also called SMN, is a bicistronic imprinted gene that encodes 2 polypeptides, the SmN splicing factor, which is involved in RNA processing, and the SNRPN upstream reading frame(SNURF) polypeptide. The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. SNRPN also encodes a long alternatively spliced transcript containing several small nucleolar RNAs(snoRNAs) and extends downstream to partially overlap the UBE3A gene in the antisense orientation. PWS arises from loss of function of genes in this region expressed exclusively from the paternal chromosome, suggesting that SNRPN may play a role in its etiology. The SNRPN gene is mapped on 15q11.2. Analysis of maternal DNA and of SNRPN cDNA confirmed that the maternal allele is not expressed in fetal brain and heart. Deletions in the transcription unit of the imprinted SNRPN gene occur in patients who have PWS or Angelman syndrome because of a parental imprint switch failure in this chromosomal domain.

ncbi gi num :

52783794

ncbi acc num :

P63162.1

uniprot acc num :

P63162

ncbi mol weight :

25,076 Da

ncbi pathways :

Gastric Cancer Network 2 Pathway (760637); MRNA Processing Pathway (198843)

ncbi summary :

The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. The protein plays a role in pre-mRNA processing, possibly tissue-specific alternative splicing events. Although individual snRNPs are believed to recognize specific nucleic acid sequences through RNA-RNA base pairing, the specific role of this family member is unknown. The protein arises from a bicistronic transcript that also encodes a protein identified as the SNRPN upstream reading frame (SNURF). Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region. Additional splice variants have been described but sequences for the complete transcripts have not been determined. The 5' UTR of this gene has been identified as an imprinting center. Alternative splicing or deletion caused by a translocation event in this paternally-expressed region is responsible for Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure. [provided by RefSeq, Jul 2008]

uniprot summary :

snRNP N: May be involved in tissue-specific alternative RNA processing events. Belongs to the snRNP SmB/SmN family. Protein type: RNA-binding. Chromosomal Location of Human Ortholog: 15q11.2. Cellular Component: small nuclear ribonucleoprotein complex; spliceosome; snRNP U2; snRNP U1. Molecular Function: protein binding; RNA binding. Biological Process: RNA splicing; response to hormone stimulus. Disease: Prader-willi Syndrome; Autism

size1 :

0.1 mg

price1 :

245 USD

more info or order :

MyBioSource product webpage