Anti-Nogo A antibody | MyBioSource MBS175437 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-Nogo A antibody

catalog :

MBS175437

quantity :

0.1 mg

price :

245 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS175437

products type :

Antibody

products full name :

Anti-Nogo A antibody

products short name :

Nogo A

products name syn :

Reticulon-4; reticulon 4; ASY antibody; Foocen antibody; Human NogoA antibody; KIAA0886 antibody; My043 protein antibody; Nbla00271 antibody; Nbla10545 antibody; Neurite growth inhibitor 220 antibody; Neurite Outgrowth Inhibitor antibody; Neuroendocrine specific protein antibody; Neuroendocrine specific protein C homolog antibody; Neuroendocrine-specific protein antibody; Neuroendocrine-specific protein C homolog antibody; NI220/250 antibody; Nogo A antibody; NOGO antibody; Nogo protein antibody; NOGO-A antibody; Nogo-B antibody; Nogo-C antibody; NogoA antibody; NSP antibody; NSP CL antibody; NSP-CL antibody; Reticulon 4 antibody; Reticulon 5 antibody; Reticulon-4 antibody; Reticulon-5 antibody; Reticulon4 antibody; Reticulon5 antibody; RTN 4 antibody; RTN 4A antibody; RTN X antibody; RTN xL antibody; RTN-x antibody; RTN4 A antibody; RTN4 antibody; RTN4 B1 antibody; RTN4 B2 antibody; RTN4 C antibody; RTN4 protein antibody; RTN4-A antibody; RTN4-B1 antibody; RTN4-B2 antibody; RTN4-C antibody; RTN4_HUMAN antibody

other names :

Reticulon-4; Reticulon-4; reticulon-4; foocen; Human NogoA; reticulon 5; My043 protein; neurite outgrowth inhibitor; neurite growth inhibitor 220; neuroendocrine-specific protein C homolog; reticulon 4; Foocen; Neurite outgrowth inhibitor; Nogo protein; Neuroendocrine-specific protein; NSP; Neuroendocrine-specific protein C homolog; RTN-x; Reticulon-5

products gene name :

RTN4

other gene names :

RTN4; RTN4; ASY; NSP; NOGO; NOGOC; RTN-X; NOGO-A; NSP-CL; Nogo-B; Nogo-C; RTN4-A; RTN4-C; RTN4-B1; RTN4-B2; NI220/250; Nbla00271; Nbla10545; KIAA0886; NOGO; Nogo protein; NSP

uniprot entry name :

RTN4_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

1192

purity :

Immunogen affinity purified.

form :

Lyophilized

storage stability :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

other info1 :

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Nogo A (1170-1192aa NKNVKDAMAKIQAKIPGLKRKAE), different from the related rat sequence by two amino acids, and from the related mouse sequence by one amino acid.

other info2 :

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

products description :

Description: Rabbit IgG polyclonal antibody for Reticulon-4(RTN4) detection. Tested with WB, IHC-P in Human, Mouse, Rat. Background: Human neurite outgrowth inhibitor(NOGO) cDNAs encodes 3 splice variants: NOGOA, NOGOB and NOGOC. The longest cDNA, designated NOGOA, has an open reading frame of 1192 amino acids. It is a potent inhibitor of neurite growth and an IN-1 antigen produced by oligodendrocytes, and may allow the generation of new reagents to enhance CNS regeneration and plasticity. Nogo-A, a member of the Reticulon family, is expressed by oligodendrocytes and associates primarily with the endoplasmic reticulum. The acidic amino terminus of Nogo-A is detected at the cytosolic face of cellular membranes and may contribute to inhibition of axon regeneration at sites of oligodendrocyte injury. A multivalent form of the N terminus of Nogo-A affects the morphology of both neurons and other cell types.

ncbi gi num :

17369290

ncbi acc num :

Q9NQC3.2

uniprot acc num :

Q9NQC3

ncbi mol weight :

108,450 Da

ncbi pathways :

Axonal Growth Inhibition (RHOA Activation) Pathway 106454!!Signal Transduction Pathway 477114!!Signalling By NGF Pathway 106439!!Spinal Cord Injury Pathway 739007!!P75 NTR Receptor-mediated Signalling Pathway 106441!!P75(NTR)-mediated Signaling Pathway 138019!!P75NTR Regulates Axonogenesis Pathway 106452

ncbi summary :

This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

size :

0.1 mg

price :

245 USD

more info or order :

MyBioSource product webpage