antibody

Polyclonal Anti-Desmoglein 2, DSG2

MBS175420

0.1 mg

315 USD

polyclonal

rabbit

nonconjugated

human, rat

western blot, immunohistochemistry, immunohistochemistry - paraffin section

Antibody

Polyclonal Anti-Desmoglein 2, DSG2

[Desmoglein 2]

[Desmoglein-2; desmoglein 2; ARVC 10 antibody; ARVC10 antibody; ARVD 10 antibody; ARVD10 antibody; Cadherin family member 5 antibody; CDHF 5 antibody; CDHF5 antibody; CMD1BB antibody; Desmoglein 2 antibody; Desmoglein-2 antibody; Desmoglein2 antibody; DSG 2 antibody; DSG2 antibody; DSG2_HUMAN antibody; HDGC antibody; HDGC included antibody; MGC117034 antibody; MGC117036 antibody; MGC117037 antibody]

[Desmoglein-2; Desmoglein-2; desmoglein-2; HDGC; cadherin family member 5; desmoglein 2; Cadherin family member 5; HDGC]

[DSG2]

[DSG2; DSG2; HDGC; CDHF5; ARVC10; ARVD10; CMD1BB; CDHF5]

DSG2_HUMAN

Polyclonal

IgG

Rabbit

Reacts with: Human, Rat; Predicted to work with: Mouse

1118

No cross reactivity with other proteins.

Immunogen affinity purified

Lyophilized; Contains 5mg BSA, 0.9mg NaCl, 0.2mg Na 2 HPO 4 , 0.05mg Thimerosal, 0.05mg NaN 3 .

At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Western Blot:. Concentration: 0.1-0.5ug/ml. Tested Species: Hu, Rat. Predicted Species: Ms. Antigen Retrieval: - . Immunohistochemistry (IHC) Paraffin:. Concentration: 0.5-1 ug/ml. Tested Species: Hu, Rat. Predicted Species: Ms. Antigen Retrieval: By Heat. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections. . Other applications have not been tested. Optimal dilutions should be determined by end users.

Western Blot (WB)

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human DSG2 (1104-1118aa STRVTKHSTVQHSYS), different from the related mouse and rat sequences by one amino acid.

Reconstitution: 0.2ml of distilled water will yield a concentration of 500ug/ml. Relevant detection: MyBioSource provides a series of assays reacted with primary antibodies. Antibody can be be supported by chemiluminescence kit MBS176460 in WB, supported by MBS176451 in IHC (P).

Desmoglein-2 is a protein that in humans is encoded by the DSG2 gene. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in DSG2 display a high degree of penetrance. Disease expression was of variable severity with LV involvement a prominent feature. The low prevalence of classical ECG changes highlights the need to expand current diagnostic criteria to take account of LV disease, childhood disease expression, and incomplete penetrance.

148876773

Q14126.2

Q14126

Apoptosis Pathway (105648); Apoptotic Cleavage Of Cell Adhesion Proteins Pathway (105680); Apoptotic Cleavage Of Cellular Proteins Pathway (105678); Apoptotic Execution Phase Pathway (105677); Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129)

Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. This gene product is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10. [provided by RefSeq, Jul 2008]

DSG2: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Defects in DSG2 are the cause of familial arrhythmogenic right ventricular dysplasia type 10 (ARVD10); also known as arrhythmogenic right ventricular cardiomyopathy 10 (ARVC10). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall. Genetic variations in DSG2 are the cause of susceptibility to cardiomyopathy dilated type 1BB (CMD1BB). A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Protein type: Membrane protein, integral; Cell adhesion; Calcium-binding. Chromosomal Location of Human Ortholog: 18q12.1. Cellular Component: desmosome; cell surface; apical plasma membrane; integral to membrane; plasma membrane; intercellular junction; lateral plasma membrane. Molecular Function: calcium ion binding. Biological Process: maternal process involved in pregnancy; apoptosis; homophilic cell adhesion; response to progesterone stimulus; cell adhesion; cell structure disassembly during apoptosis. Disease: Cardiomyopathy, Dilated, 1bb; Arrhythmogenic Right Ventricular Dysplasia, Familial, 10

0.1 mg

315 USD