antibody

Anti-BDNF antibody

MBS175418

0.1 mg

245 USD

polyclonal

rabbit

nonconjugated

human, rat

Antibody

Anti-BDNF antibody

BDNF

Brain-derived neurotrophic factor(BDNF); brain-derived neurotrophic factor; Abrineurin antibody; BDNF antibody; BDNF_HUMAN antibody; Brain Derived Neurotrophic Factor antibody; Brain-derived neurotrophic factor antibody; MGC34632 antibody; Neurotrophin antibody

Brain-derived neurotrophic factor; Brain-derived neurotrophic factor; brain-derived neurotrophic factor; abrineurin; neurotrophin; brain-derived neurotrophic factor; Abrineurin

BDNF

BDNF; BDNF; ANON2; BULN2; BDNF

BDNF_HUMAN

Polyclonal

IgG

Rabbit

Reacts with : Human . Predicted to work with: Mouse, Rat

247

No cross reactivity with other proteins.

Immunogen affinity purified.

Lyophilized

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Western Blot (WB)

Western Blot (WB):. Concentration: 0.1-0.5 ug/ml. Tested Species: Hu. Predicted Species: Ms, Rat. Antigen Retrieval: -. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminal of human BDNF (129-148aa HSDPARRGELSVCDSISEWV), identical to the related rat and mouse sequences.

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Description: Rabbit IgG polyclonal antibody for Brain-derived neurotrophic factor(BDNF) detection. Tested with WB in Human, Mouse, Rat. Background: Brain derived neurotrophic factor(BDNF) is a member of the neurotrophin family of growth factors that includes NGF, NT3, and NT4. BDNF is a prosurvival factor induced by cortical neurons that is necessary for survival of striatal neurons in the brain. BDNF is expressed within peripheral ganglia and is not restricted to neuronal target fields. BDNF has been purified and shown to reduce the amount of naturally occurring neuronal cell death in portions of the peripheral nervous system.

114900

P23560.1

P23560

31,116 Da

Alcoholism Pathway (585563); Alcoholism Pathway (587116); BDNF Signaling Pathway (712093); Cocaine Addiction Pathway (546258); Cocaine Addiction Pathway (546273); FSH Signaling Pathway (672455); Huntington's Disease Pathway (83100); Huntington's Disease Pathway (512); Integrated Pancreatic Cancer Pathway (711360); MAPK Signaling Pathway (198779)

The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jan 2009]

BDNF: During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. Defects in BDNF are a cause of congenital central hypoventilation syndrome (CCHS); also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. CCHS is frequently complicated with neurocristopathies such as Hirschsprung disease that occurs in about 16% of CCHS cases. Belongs to the NGF-beta family. 5 isoforms of the human protein are produced by alternative promoter. Protein type: Secreted, signal peptide; Cell development/differentiation; Secreted; Cytokine. Chromosomal Location of Human Ortholog: 11p13. Cellular Component: extracellular space; synaptic vesicle; mitochondrial crista; perinuclear region of cytoplasm; cytoplasmic membrane-bound vesicle; cytoplasm; dendrite; extracellular region; terminal button; perikaryon. Molecular Function: growth factor activity; neurotrophin TRKB receptor binding. Biological Process: circadian rhythm; axon guidance; mechanoreceptor differentiation; behavioral fear response; mitochondrial electron transport, NADH to ubiquinone; regulation of neuron differentiation; axon extension; response to hormone stimulus; positive regulation of long-term neuronal synaptic plasticity; response to vitamin A; negative regulation of neuroblast proliferation; ureteric bud development; dendrite development; regulation of retinal cell programmed cell death; feeding behavior; negative regulation of neuron apoptosis; response to electrical stimulus; negative regulation of synaptic transmission, GABAergic; inner ear development; response to food; nervous system development; chronic inflammatory response; response to light intensity; neuron recognition; regulation of short-term neuronal synaptic plasticity; learning; regulation of axon extension; negative regulation of striated muscle development; positive regulation of peptidyl-serine phosphorylation; positive regulation of synaptogenesis; axon target recognition; response to hyperoxia; glutamate secretion; response to hypoxia; response to fluoxetine; nerve development; response to activity; positive regulation of neuron differentiation; regulation of excitatory postsynaptic membrane potential; neurite morphogenesis; transmembrane receptor protein tyrosine kinase signaling pathway; gamma-aminobutyric acid signaling pathway. Disease: Bulimia Nervosa, Susceptibility To, 1; Obsessive-compulsive Disorder; Bulimia Nervosa, Susceptibility To, 2; Central Hypoventilation Syndrome, Congenital

0.1 mg

245 USD