Anti-AIMP2/p38 antibody | MyBioSource MBS175413 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-AIMP2/p38 antibody

catalog :

MBS175413

quantity :

0.1 mg

price :

245 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS175413

products type :

Antibody

products full name :

Anti-AIMP2/p38 antibody

products short name :

AIMP2/p38

products name syn :

Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; aminoacyl tRNA synthetase complex-interacting multifunctional protein 2; Aimp2 antibody; AIMP2_HUMAN antibody; Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 antibody; Aminoacyl tRNA synthetase complex interacting multifunctional protein 2 antibody; ARS interacting multi functional protein 2 antibody; JTV 1 antibody; JTV 1 protein antibody; JTV1 antibody; Multisynthase complex auxiliary component p38 antibody; Multisynthetase complex auxiliary component p38 antibody; P38 antibody; PRO0992 antibody; Protein JTV 1 antibody; Protein JTV-1 antibody; tRNA SYNTHETASE COFACTOR p38 antibody

other names :

Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; aminoacyl tRNA synthase complex-interacting multifunctional protein 2; protein JTV-1; ARS-interacting multi-functional protein 2; multisynthase complex auxiliary component p38; multisynthetase complex auxiliary component p38; aminoacyl tRNA synthetase complex-interacting multifunctional protein 2; Multisynthase complex auxiliary component p38; Protein JTV-1

products gene name :

AIMP2

other gene names :

AIMP2; AIMP2; P38; JTV1; JTV-1; PRO0992; JTV1

uniprot entry name :

AIMP2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

320

purity :

Immunogen affinity purified.

form :

Lyophilized

storage stability :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

other info1 :

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human AIMP2/p38 (298-320aa NVQRWMRSCENLAPFNTALKLLK), different from the related rat and mouse sequences by three amino acids.

other info2 :

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

products description :

Description: Rabbit IgG polyclonal antibody for Aminoacyl tRNA synthase complex-interacting multifunctional protein 2(AIMP2) detection. Tested with WB, IHC-P in Human, Mouse, Rat. Background: AIMP2, Aminoacyl tRNA synthetase complex-interacting multifunctional protein 2, also known as AIMP2, is an enzyme that in humans is encoded by the AIMP2 gene. AIMP2 encodes a predicted 312-amino acid protein. The AIMP2 gene is located on chromosome 7p22 flanked by two genes, HRI and PMS2. AIMP2 and HRI overlap slightly and are arranged in a tail-to-tail fashion. AIMP2 and PMS2 are separated by approximately 200 base pairs and are arranged head-to-head. AIMP2 is transcribed in the opposite direction compared to HRI and PMS2. AIMP2 is a scaffold required for the assembly and stability of the multi-tRNA synthetase complex. AIMP2 can work as a mediator of TGF-beta signaling and its functional importance in the control of MYC during lung differentiation.

ncbi gi num :

12644405

ncbi acc num :

Q13155.2

uniprot acc num :

Q13155

ncbi mol weight :

35,349 Da

ncbi pathways :

Cytosolic TRNA Aminoacylation Pathway (105981); Gene Expression Pathway (105937); Keap1-Nrf2 Pathway (198777); Osteoclast Signaling Pathway (198769); TRNA Aminoacylation Pathway (105980)

ncbi summary :

The JTV1 gene is located on chromosome 7p22 flanked by two genes, HRI and PMS2. JTV1 and HRI overlap slightly and are arranged in a tail-to-tail fashion. JTV1 and PMS2 are separated by approximately 200 base pairs and are arranged head-to-head. JTV1 is transcribed in the opposite direction compared to HRI and PMS2. The function of the JTV1 gene product is unknown. [provided by RefSeq, Jul 2008]

uniprot summary :

JTV1: Required for assembly and stability of the aminoacyl- tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down- regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. Chromosomal Location of Human Ortholog: 7p22. Cellular Component: membrane; cytosol; nucleus. Molecular Function: protein binding. Biological Process: negative regulation of cell proliferation; tRNA aminoacylation for protein translation; apoptosis; positive regulation of protein ubiquitination; gene expression

size1 :

0.1 mg

price1 :

245 USD

more info or order :

MyBioSource product webpage