Anti-CD14 antibody | MyBioSource MBS175412 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-CD14 antibody

catalog :

MBS175412

quantity :

0.1 mg

price :

245 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

mouse

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS175412

products type :

Antibody

products full name :

Anti-CD14 antibody

products short name :

CD14

products name syn :

Monocyte differentiation antigen CD14; CD14 molecule; CD 14 antibody; CD_antigen=CD14 antibody; CD14 antibody; CD14 antibody; CD14 antigen antibody; CD14 molecule antibody; CD14_HUMAN antibody; LPS-R antibody; Mo2 antibody; Monocyte differentiation antigen CD14 antibody; Monocyte differentiation antigen CD14 urinary form antibody; Monocyte differentiation antigen CD14, membrane-bound form antibody; Myeloid cell specific leucine rich glycoprotein antibody; Myeloid cell-specific leucine-rich glycoprotein antibody

other names :

Monocyte differentiation antigen CD14; Monocyte differentiation antigen CD14; monocyte differentiation antigen CD14; myeloid cell-specific leucine-rich glycoprotein; CD14 antigen; Myeloid cell-specific leucine-rich glycoprotein; CD_antigen: CD14

products gene name :

CD14

other gene names :

Cd14; Cd14

uniprot entry name :

CD14_MOUSE

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Mouse

sequence length :

366

purity :

Immunogen affinity purified.

form :

Lyophilized

storage stability :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB)

other info1 :

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of mouse CD14 (152-165aa TRDAWLAELQQWLK).

other info2 :

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

products description :

Description: Rabbit IgG polyclonal antibody for Monocyte differentiation antigen CD14(CD14) detection. Tested with WB in Mouse. Background: CD14, Cluster of differentiation 14, single-copy gene encoding 2 protein forms: a 50- to 55-kD glycosylphosphatidylinositol-anchored membrane protein(mCD14) and a monocyte or liver-derived soluble serum protein(sCD14) that lacks the anchor. By in situ hybridization and study of somatic cell hybrid DNA that the gene is located at bands 5q23-q31. CD14 acts as a co-receptor(along with the Toll-like receptor TLR 4 and MD-2) for the detection of bacterial lipopolysaccharide(LPS). CD14 can bind LPS only in the presence of lipopolysaccharide-binding protein(LBP). Although LPS is considered its main ligand, CD14 also recognizes other pathogen-associated molecular patterns.

ncbi gi num :

115957

ncbi acc num :

P10810.1

uniprot acc num :

P10810

ncbi mol weight :

39,204 Da

ncbi pathways :

Activated TLR4 Signalling Pathway (970703); Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway (1001221); Amoebiasis Pathway (167330); Amoebiasis Pathway (167191); Hematopoietic Cell Lineage Pathway (83275); Hematopoietic Cell Lineage Pathway (489); IKK Complex Recruitment Mediated By RIP1 Pathway (1001222); Immune System Pathway (971216); Innate Immune System Pathway (971212); Legionellosis Pathway (469202)

ncbi summary :

This gene encodes a protein that plays an important role in the innate immune response and is expressed in monocyte/macrophage cells. This gene product acts as a co-receptor that binds several microbial and fungal molecules, including lipopolysaccharides (LPS). This proteins LPS-binding activity is enhanced by the LPS binding protein (LBP) to allow binding to the TLR4-MD-2 co-receptor complex. The product of this gene is found in two forms, either as a soluble protein or attached to the cell surface by a glycosylphosphatidylinositol anchor. [provided by RefSeq, Jul 2014]

uniprot summary :

CD14: Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules. Protein type: Membrane protein, GPI anchor. Cellular Component: extracellular space; cell surface; membrane; plasma membrane; lipid raft. Molecular Function: lipopolysaccharide binding. Biological Process: immune system process; response to molecule of bacterial origin; innate immune response; positive regulation of endocytosis; positive regulation of tumor necrosis factor production; inflammatory response; positive regulation of cytokine secretion

size1 :

0.1 mg

price1 :

245 USD

more info or order :

MyBioSource product webpage