antibody

Anti-MRP1 antibody

MBS175406

0.1 mg

315 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, immunohistochemistry

Antibody

Anti-MRP1 antibody

[MRP1]

[Multidrug resistance-associated protein 1; ATP-binding cassette, sub-family C(CFTR/MRP), member 1; ABC 29 antibody; ABC29 antibody; ABCC 1 antibody; ABCC antibody; ABCC1 antibody; ATP binding cassette sub family C(CFTR/MRP) member 1 antibody; ATP binding cassette sub-family C member 1 antibody; ATP-binding cassette sub-family C member 1 antibody; DKFZp686N04233 antibody; DKFZp781G125 antibody; GS X antibody; GSX antibody; Leukotriene C(4) transporter antibody; LTC4 transporter antibody; MRP 1 antibody; MRP antibody; MRP1_HUMAN antibody; Multidrug resistance associated protein 1 antibody; Multidrug resistance protein antibody; Multidrug resistance-associated protein 1 antibody; Multiple drug resistance associated protein antibody; Multiple drug resistance protein 1 antibody]

[Multidrug resistance-associated protein 1; Multidrug resistance-associated protein 1; multidrug resistance-associated protein 1; LTC4 transporter; leukotriene C(4) transporter; ATP-binding cassette transporter variant ABCC1delta-ex13; ATP-binding cassette transporter variant ABCC1delta-ex25; ATP-binding cassette transporter variant ABCC1delta-ex13 ATP-binding cassette transporter variant ABCC1delta-ex25 ATP-binding cassette, sub-family C (CFTR/MRP), member 1; ATP-binding cassette sub-family C member 1; Leukotriene C(4) transporter; LTC4 transporter]

[ABCC1]

[ABCC1; ABCC1; MRP; ABCC; GS-X; MRP1; ABC29; MRP; MRP1; LTC4 transporter]

MRP1_HUMAN

Polyclonal

Rabbit IgG

Rabbit

Human, Mouse, Rat. No cross reactivity with other proteins.

1531

Immunogen affinity purified.

Lyophilized; Contains 5mg BSA, 0.9mg NaCl, 0.2mg Na 2 HPO 4 , 0.05mg Thimerosal, 0.05mg NaN 3 .

At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

Western Blot (WB), Immunohistochemistry (IHC) (Paraffin-embedded Section)

Western blot:. Concentration: 0.1-0.5ug/ml. Tested Species: Human, Rat. Concluded Species: Mouse. Antigen Retrieval: -. Immunohistochemistry (Paraffin-embedded Section): . Concentration: 0.5-1ug/ml/ml. Tested Species: Human . Predicted Species: Mouse, Rat. Antigen Retrieval: By Heat. Other applications have not been tested. Optimal dilutions should be determined by end users.

Western Blot (WB)

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human MRP1 (1514-1531aa, LLQQRGLFYSMAKDAGLV), different from the related rat and mouse sequences by one amino acid.

Reconstitution: 0.2ml of distilled water will yield a concentration of 500ug/ml.

ABCC1(ATP-BINDING CASSETTE, SUBFAMILY C, MEMBER 1), also called MRP1 or MRP, is a protein that in humans is encoded by the ABCC1 gene. The ABCC1 is a member of the superfamily of ATP-binding cassette(ABC) transporters. The ABCC1 is a plasma membrane drug-efflux pump.The ABCC1 gene is mapped to chromosome 16p13.1 by isotopic in situ hybridization. ABCC1 functions as a multispecific organic anion transporter, with oxidized glutathione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates and it also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Blocking ABCC1 efflux pumps increases the susceptibility of the cells to the toxic effects of unconjugated bilirubin, suggesting that ABCC1 is an important protector in this scenario. ABCC1 clears beta-amyloid from brains of mice and can be activated by thiethylperazine. And Chemotaxis assays show that ABCC1-mediated transport of S1P influenced mast-cell migration, but not mast-cell degranulation.

296439301

P33527.3

P33527

ABC Transporters Pathway (83035); ABC Transporters Pathway (436); ABC-family Proteins Mediated Transport Pathway (106573); Arachidonic Acid Metabolism Pathway (685553); Cobalamin (Cbl, Vitamin B12) Transport And Metabolism Pathway (833804); Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway (906000); Defective BTD Causes Biotidinase Deficiency Pathway (906015); Defective CD320 Causes Methylmalonic Aciduria Pathway (906012); Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway (906001); Defective GIF Causes Intrinsic Factor Deficiency Pathway (906004)

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]

ABCC1: a multi-pass membrane protein. A multidrug resistance member of the ABC transporter family that confers resistance to anticancer drugs. A multi-pass membrane protein. Exports sphingosine-1-phosphate (S1P), a potent inflammatory mediator, from mast cells during mast cell-mediated immune responses. Nine alternatively spliced human isoforms have been reported. Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, ABC family. Chromosomal Location of Human Ortholog: 16p13.1. Cellular Component: membrane; integral to plasma membrane; plasma membrane. Molecular Function: ATPase activity, coupled to transmembrane movement of substances; transporter activity; ATPase activity; ATP binding. Biological Process: response to drug; vitamin metabolic process; cobalamin metabolic process; transport; arachidonic acid metabolic process; leukotriene metabolic process; transmembrane transport; water-soluble vitamin metabolic process

0.1 mg

315 USD