Anti-COX2/Cyclooxygenase 2 antibody | MyBioSource MBS175390 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-COX2/Cyclooxygenase 2 antibody

catalog :

MBS175390

quantity :

0.1 mg

price :

245 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS175390

products type :

Antibody

products full name :

Anti-COX2/Cyclooxygenase 2 antibody

products short name :

COX2/Cyclooxygenase 2

products name syn :

Prostaglandin G/H synthase 2; prostaglandin-endoperoxide synthase 2(prostaglandin G/H synthase and cyclooxygenase); COX 2 antibody; COX-2 antibody; COX2 antibody; Cyclooxygenase 2 antibody; Cyclooxygenase 2b antibody; Cyclooxygenase antibody; Cyclooxygenase-2 antibody; Cyclooxygenase2 antibody; EC 1.14.99.1 antibody; fj02a10 antibody; Glucocorticoid-regulated inflammatory cyclooxygenase antibody; Glucocorticoid-regulated inflammatory Prostaglandin G/H synthase antibody; GRIPGHS antibody; hCox 2 antibody; Macrophage activation-associated marker protein P71/73 antibody; OTTHUMP00000033524 antibody; PES-2 antibody; PGG/HS antibody; PGH synthase 2 antibody; PGH2_HUMAN antibody; PGHS 2 antibody; PGHS-2 antibody; PGHS2 antibody; PHS 2 antibody; PHS II antibody; PHS2 antibody; Prostaglandin endoperoxide synthase 2(prostaglandin G/H synthase and cyclooxygenase) antibody; Prostaglandin endoperoxide synthase 2 antibody; Prostaglandin G/H synthase 2 antibody; Prostaglandin G/H synthase 2 precursor antibody; Prostaglandin G/H synthase and cyclooxygenase antibody; Prostaglandin G/H synthase antibody; Prostaglandin H2 synthase 2 antibody; prostaglandin-endoperoxide synthase 2(prostaglandin G/H synthase and cyclooxygenase antibody; Prostaglandin-endoperoxide synthase 2 antibody; PTGS2 antibody; ptgs2a antibody; TIS10 antibody; TIS10 protein antibody; unp1239 antibody; wu:fj02a10 antibody

other names :

Prostaglandin G/H synthase 2; Prostaglandin G/H synthase 2; prostaglandin G/H synthase 2; PHS II; PGH synthase 2; cyclooxygenase 2b; prostaglandin H2 synthase 2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2

products gene name :

PTGS2

other gene names :

PTGS2; PTGS2; COX2; COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; GRIPGHS; COX2; COX-2; PGH synthase 2; PGHS-2

uniprot entry name :

PGH2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

604

purity :

Immunogen affinity purified.

form :

Lyophilized

storage stability :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

other info1 :

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human COX2 (26-41aa CQNRGVCMSVGFDQYK), different from the related rat sequence by two amino acids.

other info2 :

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

products description :

Description: Rabbit IgG polyclonal antibody for Prostaglandin G/H synthase 2(PTGS2) detection. Tested with WB, IHC-P in Human, Mouse, Rat. Background: Cyclooxygenase(Cox) is the key enzyme in conversion of arachidonic acid to PGs, and two isoforms, Cox-1 and Cox-2, have been identified. Cox-2 gene encodes an inducible prostaglandin synthase enzyme that is overexpressed in adenocarcinomas and other tumors. Deletion of the murine Cox-2 gene in Min mice reduced the incidence of intestinal tumors, suggesting that it is required for tumorigenesis. This gene is localized to sites associated with retinal blood vessels, and plays an important role in blood vessel formation in the retina. And the glucocorticoid receptor suppression of COX-2 is also crucial for curtailing lethal immune activation, and suggest new therapeutic approaches for regulation of T-cell-mediated inflammatory diseases.

ncbi gi num :

3915797

ncbi acc num :

P35354.2

uniprot acc num :

P35354

ncbi mol weight :

68,996 Da

ncbi pathways :

Arachidonic Acid Metabolism Pathway (82991); Arachidonic Acid Metabolism Pathway (685553); Arachidonic Acid Metabolism Pathway (366); C-MYB Transcription Factor Network Pathway (138073); C20 Prostanoid Biosynthesis Pathway (908107); Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Calcium Signaling In The CD4+ TCR Pathway (137941); Chemical Carcinogenesis Pathway (673221); Chemical Carcinogenesis Pathway (673237); Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway (906000)

ncbi summary :

Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]

uniprot summary :

COX-2: Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity. Homodimer. Belongs to the prostaglandin G/H synthase family. Protein type: Oxidoreductase; Lipid Metabolism - arachidonic acid; EC 1.14.99.1. Chromosomal Location of Human Ortholog: 1q25.2-q25.3. Cellular Component: endoplasmic reticulum membrane; neuron projection; protein complex; cytoplasm; caveola; nucleus. Molecular Function: prostaglandin-endoperoxide synthase activity; enzyme binding; peroxidase activity; protein homodimerization activity; arachidonate 15-lipoxygenase activity; metal ion binding; heme binding; lipid binding. Biological Process: positive regulation of nitric oxide biosynthetic process; positive regulation of apoptosis; response to lithium ion; positive regulation of smooth muscle cell proliferation; response to glucocorticoid stimulus; response to lipopolysaccharide; positive regulation of NF-kappaB import into nucleus; decidualization; sensory perception of pain; prostaglandin biosynthetic process; negative regulation of synaptic transmission, dopaminergic; positive regulation of synaptic transmission, glutamatergic; response to estradiol stimulus; bone mineralization; negative regulation of cell cycle; negative regulation of cell proliferation; response to vitamin D; lipoxygenase pathway; nicotinamide metabolic process; negative regulation of smooth muscle contraction; regulation of blood pressure; arachidonic acid metabolic process; positive regulation of smooth muscle contraction; angiogenesis; inflammatory response; response to fructose stimulus; water-soluble vitamin metabolic process; positive regulation of prostaglandin biosynthetic process; response to drug; negative regulation of calcium ion transport; vitamin metabolic process; cyclooxygenase pathway; positive regulation of synaptic plasticity; learning; memory; prostaglandin metabolic process; hair cycle; response to manganese ion; ovulation; NAD metabolic process; regulation of inflammatory response; positive regulation of vasoconstriction; positive regulation of fever; brown fat cell differentiation; response to oxidative stress; cell motility; embryo implantation

size1 :

0.1 mg

price1 :

245 USD

more info or order :

MyBioSource product webpage