Anti-beta Defensin 1 antibody | MyBioSource MBS175382 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-beta Defensin 1 antibody

catalog :

MBS175382

quantity :

0.1 mg

price :

315 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS175382

products type :

Antibody

products full name :

Anti-beta Defensin 1 antibody

products short name :

[beta Defensin 1]

products name syn :

[Beta-defensin 1(BD-1/hBD-1); defensin, beta 1; BD 1 antibody; BD-1 antibody; BD1 antibody; beta 1 antibody; Beta defensin 1 antibody; Beta-defensin 1 antibody; DEFB 1 antibody; DEFB1 antibody; DEFB1_HUMAN antibody; DEFB101 antibody; Defensin antibody; Defensin beta 1 antibody; Defensin beta 1 preproprotein antibody; HBD 1 antibody; hBD-1 antibody; HBD1 antibody; MGC51822 antibody]

other names :

[Beta-defensin 1; Beta-defensin 1; beta-defensin 1; BD-1; beta-defensin-1; defensin, beta 1; Defensin, beta 1]

products gene name :

[DEFB1]

other gene names :

[DEFB1; DEFB1; BD1; HBD1; DEFB-1; DEFB101; BD1; HBD1; BD-1; hBD-1]

uniprot entry name :

DEFB1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

specificity :

No cross reactivity with other proteins.

purity :

Immunogen affinity purified.

form :

Lyophilized

storage stability :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

app notes :

Western Blot: . Concentration: 0.1-0.5ug/ml. Tested Species: Human. Predicted Species: - . Antigen Retrieval: -. Immunohistochemistry (Paraffin-embedded Section):. Concentration: 0.5-1ug/ml. Tested Species: Human. Predicted Species: - . Antigen Retrieval: By Heat. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH 6.0, for 20 mins is required for the staining of the formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

other info1 :

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human beta Defensin 1 (52-68aa FTKIQGTCYRGKAKCCK).

other info2 :

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

products description :

DEFB1,Beta-defensin 1, is a protein that in humans is encoded by the DEFB1 gene. DEFB1 belongs to the defensin family. Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. The DEFB1 gene spans more than 7 kb and includes a large 6,962-bp intron. By 2-color fluorescence in situ hybridization on both metaphase chromosomes and released chromatin fiber, the DEFB1gene is mapped to 8p23.2-p23.1, within 100 to 150 kb of the gene for human neutrophil defensin-alpha-1. DEFB1may augment neonatal host defenses through antimicrobial effects or prime the adaptive immune system at mucosal surfaces.

ncbi gi num :

38503374

ncbi acc num :

P60022.1

uniprot acc num :

P60022

ncbi pathways :

Beta Defensins Pathway (530759); Defensins Pathway (530757); Immune System Pathway (106386); Innate Immune System Pathway (106387)

ncbi summary :

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis. [provided by RefSeq, Jul 2008]

uniprot summary :

defensin, beta 1: Has bactericidal activity. Belongs to the beta-defensin family. Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 8p23.1. Cellular Component: extracellular space; Golgi lumen; extracellular region. Biological Process: G-protein coupled receptor protein signaling pathway; defense response to Gram-positive bacterium; innate immune response in mucosa; response to bacterium; antibacterial humoral response; innate immune response; immune response; response to testosterone stimulus; chemotaxis; acute inflammatory response

size1 :

0.1 mg

price1 :

315 USD

more info or order :

MyBioSource product webpage