Polyclonal Anti-GJA5 Antibody | MyBioSource MBS175364 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Polyclonal Anti-GJA5 Antibody

catalog :

MBS175364

quantity :

0.1 mg

price :

245 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS175364

products type :

Antibody

products full name :

Polyclonal Anti-GJA5 Antibody

products short name :

GJA5

products name syn :

Gap junction alpha-5 protein; gap junction protein, alpha 5, 40kDa; Connexin 40 antibody; Connexin-40 antibody; Cx40 antibody; CXA5_HUMAN antibody; Gap junction alpha 5 protein antibody; Gap junction alpha-5 protein antibody; Gap junction protein alpha 5 40kD(connexin 40) antibody; Gap junction protein alpha 5 antibody; GJA5 antibody; MGC11185 antibody

other names :

Gap junction alpha-5 protein; Gap junction alpha-5 protein; gap junction alpha-5 protein; connexin 40; gap junction protein alpha 5 40kDa; gap junction protein, alpha 5, 40kDa; Connexin-40; Cx40

products gene name :

GJA5

other gene names :

GJA5; GJA5; CX40; ATFB11; Cx40

uniprot entry name :

CXA5_HUMAN

clonality :

Polyclonal

isotype :

Rabbit IgG

host :

Rabbit

reactivity :

Reacts with: Human, Mouse, Rat

sequence length :

358

specificity :

No cross reactivity with other proteins.

purity :

Immunogen affinity purified.

form :

Lyophilized

storage stability :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

app notes :

Western Blot:. Concentration: 0.1-0.5 ug/ml. Tested Species: Ms . Predicted Species: Hu, Rat. Antigen Retrieval: -. Immunohistochemistry (Paraffin-embedded Section):. Concentration: 0.5-1 ug/ml. Tested Species: Hu, Rat . Predicted Species: Ms. Antigen Retrieval: By Heat. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20 mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by the end users.

other info1 :

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Connexin 40/GJA5 (341-358aa KRRLSKASSKARSDDLSV), identical to the related mouse and rat sequences.

other info2 :

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

products description :

Description: Rabbit IgG polyclonal antibody for Gap junction alpha-5 protein(GJA5) detection. Tested with WB, IHC-P in Human, Mouse, Rat. Background: Connexin proteins oligomerize to form intercellular channels, called gap junctions, through which ions and small molecules move between adjacent cells. Connexin 40(Gap junction alpha-5 protein) is a protein that in humans is encoded by the GJA5 gene.This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene may be associated with atrial fibrillation. Alternatively spliced transcript variants encoding the same isoform have been described.

ncbi gi num :

8928556

ncbi acc num :

P36382.3

uniprot acc num :

P36382

ncbi mol weight :

40,380 Da

ncbi pathways :

Calcium Regulation In The Cardiac Cell Pathway (198906); Gap Junction Assembly Pathway (105928); Gap Junction Trafficking Pathway (105927); Gap Junction Trafficking And Regulation Pathway (105926); Membrane Trafficking Pathway (106160)

ncbi summary :

This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene may be associated with atrial fibrillation. Alternatively spliced transcript variants encoding the same isoform have been described. [provided by RefSeq, Jul 2008]

uniprot summary :

GJA5: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Defects in GJA5 are a cause of familial atrial standstill (FAS). Atrial standstill is an extremely rare arrhythmia, characterized by the absence of electrical and mechanical activity in the atria. Electrocardiographically, it is characterized by bradycardia, the absence of P waves, and a junctional narrow complex escape rhythm. Defects in GJA5 are the cause of familial atrial fibrillation type 11 (ATFB11). ATFB11 is a familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the connexin family. Alpha-type (group II) subfamily. Protein type: Channel, misc.; Motility/polarity/chemotaxis; Membrane protein, multi-pass; Membrane protein, integral. Chromosomal Location of Human Ortholog: 1q21.1. Cellular Component: connexon complex; cell projection; integral to plasma membrane; gap junction. Molecular Function: gap junction hemi-channel activity. Biological Process: gap junction assembly; negative regulation of glomerular filtration; positive regulation of vasodilation; protein oligomerization; positive regulation of vasoconstriction; artery morphogenesis; embryonic heart tube development; negative regulation of blood pressure; angiogenesis; skeletal development; transmembrane transport; potassium ion transport; embryonic limb morphogenesis. Disease: Atrial Standstill 1; Atrial Fibrillation, Familial, 11

size1 :

0.1 mg

price1 :

245 USD

more info or order :

MyBioSource product webpage