antibody

Anti-SNAP23 antibody

MBS175361

0.1 mg

245 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, immunohistochemistry, immunohistochemistry - paraffin section

Antibody

Anti-SNAP23 antibody

SNAP23

Synaptosomal-associated protein 23(SNAP-23); synaptosomal-associated protein, 23kDa; HsT17016 antibody; LS-B8340 antibody; SNAP 23 antibody; SNAP-23 antibody; SNAP23 antibody; SNAP23A antibody; SNAP23B antibody; SNP23_HUMAN antibody; Synaptosomal associated protein 23 antibody; Synaptosomal associated protein 23kDa antibody; Synaptosomal associated protein antibody; Synaptosomal-associated protein 23 antibody; Vesicle membrane fusion protein SNAP 23 antibody; Vesicle membrane fusion protein SNAP23 antibody; Vesicle-membrane fusion protein SNAP-23 antibody

Synaptosomal-associated protein 23; Synaptosomal-associated protein 23; synaptosomal-associated protein 23; synaptosomal-associated protein, 23kD; vesicle-membrane fusion protein SNAP-23; synaptosomal-associated protein, 23kDa; Vesicle-membrane fusion protein SNAP-23

SNAP23

SNAP23; SNAP23; SNAP-23; SNAP23A; SNAP23B; HsT17016; SNAP-23

SNP23_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

211

Immunogen affinity purified.

Lyophilized

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunohistochemistry (IHC) Formalin

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human SNAP23 (192-211aa DTNRDRIDIANARAKKLIDS), different from the related rat and mouse sequences by three amino acids.

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Description: Rabbit IgG polyclonal antibody for Synaptosomal-associated protein 23(SNAP23) detection. Tested with WB, IHC-P, IHC-F in Human, Mouse, Rat. Background: SNAP23(Synaptosomal-Associated Protein, 23-KD), also called SNAP23A, is a protein that in humans is encoded by the SNAP23 gene. The SNAP23 gene has 8 exons, with the initiation codon located in exon 2. The SNAP23 gene is mapped on 15q15.1-q15.2. The SNAP23 cDNA encodes a 211-amino acid polypeptide with a predicted mass of 23 kD. Its amino acid sequence is 59% identical to that of SNAP25. Northern blot analysis revealed that SNAP23 is ubiquitously expressed. SNAP23 is able to bind to multiple syntaxins as well as to multiple vesicle-associated membrane proteins. After relocation, SNAP23 is required for exocytosis, implying a crucial role in promoting membrane fusion. TIVAMP-containing vesicles were concentrated in the apical domain of epithelial cells. STX3A and SNAP23 were codistributed at the apical plasma membrane, where they formed N-ethyl maleimide-dependent SNARE complexes with TIVAMP and cellubrevin. SNAP23 is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion.

6685971

O00161.1

O00161

17,789 Da

Clathrin Derived Vesicle Budding Pathway 119545!!Insulin Signaling Pathway 198845!!Membrane Trafficking Pathway 106160!!Platelet Activation Pathway 952858!!SNARE Interactions In Vesicular Transport Pathway 83057!!SNARE Interactions In Vesicular Transport Pathway 467!!Translocation Of GLUT4 To The Plasma Membrane Pathway 685554!!Trans-Golgi Network Vesicle Budding Pathway 106165

Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

0.1 mg

245 USD