Anti-Kallikrein 1 antibody | MyBioSource MBS175345 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-Kallikrein 1 antibody

catalog :

MBS175345

quantity :

0.1 mg

price :

245 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

mouse

application :

western blot, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS175345

products type :

Antibody

products full name :

Anti-Kallikrein 1 antibody

products short name :

Kallikrein 1

products name syn :

Kallikrein-1; kallikrein 1; Glandular kallikrein 1 antibody; hK 1 antibody; hK1 antibody; Kallikrein serine protease 1 antibody; Kallikrein-1 antibody; Kidney/pancreas/salivary gland kallikrein antibody; Klk 6 antibody; KLK1 antibody; KLK1_HUMAN antibody; Klk6 antibody; KLKR antibody; Tissue kallikrein antibody

other names :

Kallikrein-1; Kallikrein-1; kallikrein-1; KAL-B; kallikrein 6; renal kallikrein; tissue kallikrein-6; true tissue kallikrein; glandular kallikrein K1; kallikrein renal/pancreas/salivary; kallikrein 1; Glandular kallikrein K1; KAL-B; Renal kallikrein; Tissue kallikrein-6; mGK-6

products gene name :

KLK1

other gene names :

Klk1; Klk1; Kal; Klk6; mGk-6; Klk1b6; 0610007D04Rik; Klk-6; Klk6; mGK-6

uniprot entry name :

KLK1_MOUSE

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Mouse

sequence length :

261

specificity :

No cross reactivity with other proteins.

purity :

Immunogen affinity purified.

form :

Lyophilized

storage stability :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P)

app notes :

WB: . Concentration:0.1-0.5ug/ml. Tested Species: Ms. IHC-P: . Concentration: 0.5-1ug/ml. Tested Species: MS. Antigen Retrieval: By Heat. Tested Species: In-house tested species with positive results. Predicted Species: Species to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

other info1 :

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of mouse Kallikrein 1 (243-261aa YTRVLNFNTWIRETMAEND).

other info2 :

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

products description :

Description: Rabbit IgG polyclonal antibody for Kallikrein-1(KLK1) detection. Tested with WB, IHC-P in Mouse. Background: KLK1(KALLIKREIN 1), also called KLKR, is a protein that in humans is encoded by the KLK1 gene. KLK1 is a member of the peptidase S1 family. KLK1 is a serine protease that generates Lys-bradykinin by specific proteolysis of kininogen-1. The KLK1 gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19 and its exact cytogenetic location is 19q13.33. The KLK1 gene contains 5 coding exons. And KLK1 is the most centromeric gene in the cluster. Mice lacking tissue kallikrein are unable to generate significant levels of kinins in most tissues and develop cardiovascular abnormalities early in adulthood despite normal blood pressure. The protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen.

ncbi gi num :

17433705

ncbi acc num :

P15947.3

uniprot acc num :

P15947

ncbi mol weight :

28,775 Da

ncbi pathways :

Activation Of Matrix Metalloproteinases Pathway (1001029); Degradation Of The Extracellular Matrix Pathway (1001028); Endocrine And Other Factor-regulated Calcium Reabsorption Pathway (213309); Endocrine And Other Factor-regulated Calcium Reabsorption Pathway (213276); Extracellular Matrix Organization Pathway (1001015); Metabolism Of Proteins Pathway (970583); Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway (1000422)

uniprot summary :

KLK1: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Belongs to the peptidase S1 family. Kallikrein subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 3.4.21.35; Protease. Cellular Component: nucleus. Molecular Function: peptidase activity; hydrolase activity; serine-type peptidase activity; serine-type endopeptidase activity; catalytic activity. Biological Process: proteolysis

size1 :

0.1 mg

price1 :

245 USD

more info or order :

MyBioSource product webpage