Anti-CD68 antibody | MyBioSource MBS175328 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-CD68 antibody

catalog :

MBS175328

quantity :

0.1 mg

price :

245 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS175328

products type :

Antibody

products full name :

Anti-CD68 antibody

products short name :

CD68

products name syn :

Macrosialin; CD68 molecule; CD 68 antibody; CD68 antibody; CD68 antigen antibody; CD68 molecule antibody; CD68_HUMAN antibody; DKFZp686M18236 antibody; GP110 antibody; LAMP4 antibody; Macrophage antigen CD68(microsialin) antibody; MACROPHAGE ANTIGEN CD68 antibody; macrosialin antibody; SCARD1 antibody; Scavenger receptor class D member 1 antibody

other names :

Macrosialin; Macrosialin; macrosialin; CD68 antigen; CD_antigen: CD68

products gene name :

CD68

other gene names :

Cd68; Cd68; Lamp4; gp110; Scard1

uniprot entry name :

CD68_MOUSE

clonality :

Polyclonal

isotype :

Rabbit IgG

host :

Rabbit

reactivity :

Mouse, Rat

sequence length :

326

specificity :

No cross reactivity with other proteins.

purity :

Immunogen affinity purified.

form :

Lyophilized

storage stability :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunohistochemistry (IHC) Formalin

app notes :

Western Blot:. Concentration: 0.1-0.5ug/ml. Tested Species: Rat. Predicted Species: Ms. Antigen Retrieval: -. Immunohistochemistry (Paraffin-embedded Section):. Concentration: 0.5-1ug/ml. Tested Species: Ms,Rat. Predicted Species: - . Antigen Retrieval: By Heat. Immunohistrochemistry (Frozen Section):. Concentration: 0.5-1ug/ml. Tested Species: Ms,Rat. Predicted Species: - . Antigen Retrieval: -. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

other info1 :

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of mouse CD68 (312-326aa AFCITRRRQSTYQPL), different from the related rat sequence by one amino acid.

other info2 :

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

products description :

Description: Rabbit IgG polyclonal antibody for Macrosialin(CD68) detection. Tested with WB, IHC-P, IHC-F in Mouse, Rat. Background: CD68, cluster of differentiation, is a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. CD68 is a member of a family of hematopoietic mucin-like molecules that includes leukosialin/CD43 and stem cell antigen CD34. The CD68 gene is mapped to 17p13.1. Immunohistochemistry can be used to identify the presence of CD68, which is found in the cytoplasmic granules of a range of different blood cells. It is particularly useful as a marker for the various cells of the macrophage lineage, including monocytes, histiocytes, giant cells, Kupffer cells, and osteoclasts. This allows it to be used to distinguish diseases of otherwise similar appearance, such as the monocyte/macrophage and lymphoid forms of leukaemia(the latter being CD68 negative). Its presence in macrophages also makes it useful in diagnosing conditions related to proliferation or abnormality of these cells, such as malignant histiocytosis, histiocytic lymphoma, and Gaucher's disease.

ncbi gi num :

399215

ncbi acc num :

P31996.1

uniprot acc num :

P31996

ncbi mol weight :

33,844 Da

ncbi pathways :

Lysosome Pathway (99272); Lysosome Pathway (96865); Macrophage Markers Pathway (672439)

uniprot summary :

CD68: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells. Belongs to the LAMP family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cell surface; Membrane protein, integral. Cellular Component: membrane; lysosome; integral to membrane; plasma membrane; endosome

size1 :

0.1 mg

price1 :

245 USD

more info or order :

MyBioSource product webpage