antibody

Anti-S100 beta antibody

MBS175312

0.1 mg

245 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

Antibody

Anti-S100 beta antibody

S100 beta

Protein S100-B; S100 calcium binding protein B; NEF antibody; Protein S100 B antibody; Protein S100-B antibody; S 100 calcium binding protein beta chain antibody; S 100 protein beta chain antibody; S 100 protein beta subunit antibody; S-100 protein beta chain antibody; S-100 protein subunit beta antibody; S100 antibody; S100 calcium binding protein B antibody; S100 calcium binding protein beta(neural) antibody; S100 calcium binding protein beta chain antibody; S100 calcium-binding protein B antibody; S100 protein beta chain antibody; S100B antibody; S100B_HUMAN antibody; S100beta antibody

Protein S100-B; Protein S100-B; protein S100-B; S-100 protein subunit beta; S-100 calcium-binding protein, beta chain; S100 calcium-binding protein, beta (neural); S100 calcium binding protein B; S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B

S100B

S100B; S100B; NEF; S100; S100-B; S100beta

S100B_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

92

Immunogen affinity purified.

Lyophilized

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Western Blot (WB)

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human S100 beta (64-78aa DGDGECDFQEFMAFV), identical to the related rat and mouse sequences.

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Description: Rabbit IgG polyclonal antibody for Protein S100-B(S100B) detection. Tested with WB in Human, Mouse, Rat. Background: S100 calcium binding protein B or S100B is a protein of the S-100 protein family. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. S100B is a glial-derived protein that is a well-established biomarker for severity of neurological injury and prognosis for recovery. S100 beta is a calcium-binding protein that is expressed at high levels in brain primarily by astrocytes. Addition of the disulfide-bonded dimeric form of S100 beta to primary neuronal and glial cultures and established cell lines induces axonal extension and alterations in astrocyte proliferation and phenotype, but evidence that S100 beta exerts the same effects in vivo has not been presented. Reeves et al.(1994) demonstrated that the same effects of the S100B protein are exerted in vivo. They found that both astrocytosis and neurite proliferation occurred in transgenic mice expressing elevated levels of S100b. They suggested that these transgenic mice represent a useful model for studies of the role of S100B in glial-neuronal interactions in normal development and function of the brain and for analyzing the significance of elevated levels of the protein in Down syndrome and Alzheimer disease.

134138

P04271.2

P04271

10,713 Da

Activated TLR4 Signalling Pathway 106400!!Advanced Glycosylation Endproduct Receptor Signaling Pathway 187092!!Cytosolic Sensors Of Pathogen-associated DNA Pathway 576255!!DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway 833822!!Immune System Pathway 106386!!Innate Immune System Pathway 106387!!MyD88 Cascade Initiated On Plasma Membrane Pathway 205107!!MyD88 Dependent Cascade Initiated On Endosome Pathway 187081!!MyD88-independent Cascade Pathway 106401!!MyD88:Mal Cascade Initiated On Plasma Membrane Pathway 106390

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq, Jul 2008]

0.1 mg

245 USD