Anti-CD62E antibody | MyBioSource MBS175278 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-CD62E antibody

catalog :

MBS175278

quantity :

0.1 mg

price :

245 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

product information

catalog number :

MBS175278

products type :

Antibody

products full name :

Anti-CD62E antibody

products short name :

CD62E

products name syn :

E-selectin; selectin E; CD 62E antibody; CD26E antibody; CD62 antigen-like family member E antibody; CD62E antibody; CD62E antigen antibody; E selectin antibody; E-selectin antibody; ELAM 1 antibody; ELAM antibody; ELAM-1 antibody; ELAM1 antibody; Endothelial adhesion molecule 1 antibody; Endothelial leukocyte adhesion molecule 1 antibody; ESEL antibody; LECAM 2 antibody; LECAM2 antibody; Leukocyte endothelial cell adhesion molecule 2 antibody; Leukocyte-endothelial cell adhesion molecule 2 antibody; LYAM2_HUMAN antibody; SELE antibody; Selectin E antibody; SelectinE antibody

other names :

E-selectin; E-selectin; E-selectin; ELAM-1; endothelial adhesion molecule 1; CD62 antigen-like family member E; endothelial leukocyte adhesion molecule 1; leukocyte endothelial cell adhesion molecule 2; leukocyte-endothelial cell adhesion molecule 2; selectin E; CD62 antigen-like family member E; Endothelial leukocyte adhesion molecule 1; ELAM-1; Leukocyte-endothelial cell adhesion molecule 2; LECAM2; CD_antigen: CD62E

products gene name :

SELE

other gene names :

SELE; SELE; ELAM; ESEL; CD62E; ELAM1; LECAM2; ELAM1; ELAM-1; LECAM2

uniprot entry name :

LYAM2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

610

purity :

Immunogen affinity purified.

form :

Lyophilized

storage stability :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

other info1 :

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human CD62E (33-50aa YDEASAYCQQRYTHLVAI), different from the related rat and mouse sequences by two amino acids.

other info2 :

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

products description :

Description: Rabbit IgG polyclonal antibody for E-selectin(SELE) detection. Tested with WB, IHC-P in Human, Mouse, Rat. Background: E-Selectin(SELE), also called Selectin E, ELAM1 or ELAM, is a cell adhesion molecule expressed only on endothelial cells activated by cytokines. It is though to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. E-Selection is a member of the selectin family of cell adhesion molecules. The E-Selectin gene is mapped on 1q24.2. The ELAM gene is present in single copy in the human genome and contains 14 exons spanning about 13 kb of DNA by Collins et al. Using affinity chromatography, pull-down assays, and mass spectrometric analysis on adenocarcinoma cell lines, Gout et al. showed that SELE bound death receptor-3 on the cancer cells. Western blot analysis revealed that the SELE-binding protein was recognized by anti-DR3 antibodies. Anti-DR3 or knockdown of DR3 by small interfering RNA decreased adhesion of colon cancer cells to SELE and to SELE-expressing endothelial cells.

ncbi gi num :

126180

ncbi acc num :

P16581.1

uniprot acc num :

P16581

ncbi mol weight :

66,655 Da

ncbi pathways :

ATF-2 Transcription Factor Network Pathway 138006!!African Trypanosomiasis Pathway 194384!!African Trypanosomiasis Pathway 194323!!Cell Adhesion Molecules (CAMs) Pathway 83069!!Cell Adhesion Molecules (CAMs) Pathway 480!!Cell Surface Interactions At The Vascular Wall Pathway 106062!!Glucocorticoid Receptor Regulatory Network Pathway 138014!!Hemostasis Pathway 106028!!Malaria Pathway 152665!!Malaria Pathway 152657

ncbi summary :

The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]

size :

0.1 mg

price :

245 USD