Anti-RANK antibody | MyBioSource MBS175230 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-RANK antibody

catalog :

MBS175230

quantity :

0.1 mg

price :

245 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS175230

products type :

Antibody

products full name :

Anti-RANK antibody

products short name :

RANK

products name syn :

Tumor necrosis factor receptor superfamily member 11A; tumor necrosis factor receptor superfamily, member 11a, NFKB activator; Activator of NFKB antibody; CD 265 antibody; CD265 antibody; CD265 antigen antibody; EOF antibody; FEO antibody; LOH18CR1 antibody; Loss of heterozygosity 18 chromosomal region 1 antibody; mRANK antibody; NFKB activator antibody; ODFR antibody; OFE antibody; OPTB7 antibody; Osteoclast differentiation factor receptor antibody; OSTS antibody; PDB 2 antibody; PDB2 antibody; RANK antibody; Receptor activator of NF KB antibody; Receptor activator of NF-KB antibody; receptor activator of nuclear factor kappa B antibody; TNFRSF 11A antibody; TNFRSF11A antibody; TNFSF11 antibody; TNR11_HUMAN antibody; TRANCE R antibody; TRANCER antibody; Tumor necrosis factor receptor superfamily member 11a NFKB activator antibody; Tumor necrosis factor receptor superfamily member 11a activator of NFKB antibody; Tumor Necrosis Factor Receptor Superfamily Member 11a antibody

other names :

Tumor necrosis factor receptor superfamily member 11A; Tumor necrosis factor receptor superfamily member 11A; tumor necrosis factor receptor superfamily member 11A; Paget disease of bone 2; receptor activator of NF-KB; osteoclast differentiation factor receptor; receptor activator of nuclear factor-kappa B; loss of heterozygosity, 18, chromosomal region 1; tumor necrosis factor receptor superfamily, member 11a, NFKB activator; Osteoclast differentiation factor receptor; ODFR; Receptor activator of NF-KB; CD_antigen: CD265

products gene name :

TNFRSF11A

other gene names :

TNFRSF11A; TNFRSF11A; FEO; OFE; ODFR; OSTS; PDB2; RANK; CD265; OPTB7; TRANCER; LOH18CR1; RANK; ODFR

uniprot entry name :

TNR11_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

616

purity :

Immunogen affinity purified.

form :

Lyophilized

storage stability :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

other info1 :

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human RANK (29-44aa QIAPPCTSEKHYEHLG).

other info2 :

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

products description :

Description: Rabbit IgG polyclonal antibody for Tumor necrosis factor receptor superfamily member 11A(TNFRSF11A) detection. Tested with WB, IHC-P in Human. Background: Receptor Activator of Nuclear Factor K B(RANK), also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK is also expressed on dendritic cells and facilitates immune signaling. RANKL(Receptor Activator for Nuclear Factor K B Ligand) is found on the surface of stromal cells, osteoblasts, and T cells. By analysis of somatic cell and radiation hybrid panels, Anderson et al.(1997) mapped the RANK gene to 18q22.1.

ncbi gi num :

19924309

ncbi acc num :

Q9Y6Q6.1

uniprot acc num :

Q9Y6Q6

ncbi mol weight :

64,552 Da

ncbi pathways :

Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!NF-kappa B Signaling Pathway 634527!!Osteoclast Signaling Pathway 198769!!Osteoclast Differentiation Pathway 193147!!Osteoclast Differentiation Pathway 193096!!Prolactin Signaling Pathway 814182!!Prolactin Signaling Pathway 814248!!RANKL/RANK Signaling Pathway 672447!!Rheumatoid Arthritis Pathway 200309

ncbi summary :

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012]

size :

0.1 mg

price :

245 USD

more info or order :

MyBioSource product webpage