Anti-Indoleamine 2, 3-dioxygenase antibody | MyBioSource MBS175210 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-Indoleamine 2, 3-dioxygenase antibody

catalog :

MBS175210

quantity :

0.1 mg

price :

245 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, cow

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS175210

products type :

Antibody

products full name :

Anti-Indoleamine 2, 3-dioxygenase antibody

products short name :

Indoleamine 2, 3-dioxygenase

products name syn :

Indoleamine 2,3-dioxygenase 1(IDO-1); indoleamine 2,3-dioxygenase 1; 3-dioxygenase antibody; I23O1_HUMAN antibody; IDO 1 antibody; IDO antibody; IDO-1 antibody; IDO1 antibody; INDO antibody; indolamine 2,3 dioxygenase antibody; Indole 2 3 dioxygenase antibody; indoleamine 2 3 dioxygenase 1 antibody; indoleamine 2 3 dioxygenase antibody; Indoleamine 2,3-dioxygenase 1 antibody; Indoleamine pyrrole 2 3 dioxygenase antibody; Indoleamine-pyrrole 2 antibody

other names :

Indoleamine 2,3-dioxygenase 1; Indoleamine 2,3-dioxygenase 1; indoleamine 2,3-dioxygenase 1; indole 2,3-dioxygenase; indolamine 2,3 dioxygenase; indoleamine-pyrrole 2,3-dioxygenase; indoleamine 2,3-dioxygenase 1; Indoleamine-pyrrole 2,3-dioxygenase

products gene name :

IDO1

other gene names :

IDO1; IDO1; IDO; INDO; IDO-1; IDO; INDO; IDO-1

uniprot entry name :

I23O1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Reacts with: Cynomolgus monkey. N.B. Antibody reactivity and working conditions may vary between species.

sequence length :

403

specificity :

No cross reactivity with other proteins

purity :

Immunogen affinity purified.

form :

Lyophilized

storage stability :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB)

app notes :

Western Blot:. Concentration: 0.1-0.5ug/ml. Tested Species: Hu. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions shold be determined by end users.

other info1 :

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human IDO1(1-20aa MAHAMENSWTISKEYHIDEE).

other info2 :

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Buffer Solution: Phosphate buffered saline

products description :

Description: Rabbit IgG polyclonal antibody for Indoleamine 2,3-dioxygenase 1(IDO1) detection. Tested with WB in Human. Background: IDO1(INDOLEAMINE 2,3-DIOXYGENASE), INDO or IDO, is an immunomodulatory enzyme produced by some alternatively activated macrophages and other immunoregulatory cells. This enzyme catalyzes the degradation of the essential amino acid L-tryptophan to N-formyl-kynurenine. By fluorescence in situ hybridization, the assignment is narrowed to chromosome 8p12-p11. INDO Interferon-gamma has an antiproliferative effect on many tumor cells and inhibits intracellular pathogens such as Toxoplasma and chlamydia, at least partly because of the induction of indoleamine 2,3-dioxygenase. During inflammation, IDO is upregulated in dendritic cells and phagocytes by proinflammatory stimuli, most notably IFNG, and the enzyme then uses superoxide as a 'cofactor' for oxidative cleavage of the indole ring of tryptophan, yielding an intermediate that deformylates to L-kynurenine.

ncbi gi num :

123948

ncbi acc num :

P14902.1

uniprot acc num :

P14902

ncbi mol weight :

45,326 Da

ncbi pathways :

African Trypanosomiasis Pathway (194384); African Trypanosomiasis Pathway (194323); Metabolic Pathways (132956); Metabolism Pathway (477135); Metabolism Of Amino Acids And Derivatives Pathway (106169); NAD Biosynthesis II (from Tryptophan) Pathway (138368); Tryptophan Catabolism Pathway (106190); Tryptophan Metabolism Pathway (82964); Tryptophan Metabolism Pathway (198850); Tryptophan Metabolism Pathway (332)

ncbi summary :

This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]

uniprot summary :

INDO: Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen. Belongs to the indoleamine 2,3-dioxygenase family. Protein type: EC 1.13.11.52; Oxidoreductase; Amino Acid Metabolism - tryptophan; Cell cycle regulation. Chromosomal Location of Human Ortholog: 8p12-p11. Cellular Component: smooth muscle contractile fiber; stereocilium bundle; cytosol. Molecular Function: electron carrier activity; metal ion binding; indoleamine 2,3-dioxygenase activity; heme binding; tryptophan 2,3-dioxygenase activity. Biological Process: regulation of activated T cell proliferation; positive regulation of T-helper 2 type immune response; positive regulation of chronic inflammatory response; negative regulation of interleukin-10 production; positive regulation of interleukin-12 production; tryptophan catabolic process to kynurenine; response to lipopolysaccharide; female pregnancy; negative regulation of T cell proliferation; cytokine production during acute inflammatory response; tryptophan catabolic process; multicellular organismal response to stress; positive regulation of T cell tolerance induction

size1 :

0.1 mg

price1 :

245 USD

more info or order :

MyBioSource product webpage