Anti-5HT2A Receptor antibody | MyBioSource MBS175200 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-5HT2A Receptor antibody

catalog :

MBS175200

quantity :

0.1 mg

price :

245 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; rat; 1:200 western blot; rat; 1:1000	Ayme Dietrich E, Marzak H, Lawson R, Mokni W, Wendling O, Combe R, et al. Contribution of serotonin to cardiac remodeling associated with hypertensive diastolic ventricular dysfunction in rats. J Hypertens. 2015;33:2310-21 pubmed publisher

product information

catalog number :

MBS175200

products type :

Antibody

products full name :

Anti-5HT2A Receptor antibody

products short name :

5HT2A Receptor

products name syn :

5-hydroxytryptamine receptor 2A(5-HT-2/5-HT-2A); 5-hydroxytryptamine(serotonin) receptor 2A, G protein-coupled; 5 HT 2 antibody; 5 HT 2A antibody; 5 HT2 receptor antibody; 5 HT2A antibody; 5 hydroxytryptamine receptor 2A antibody; 5-HT-2 antibody; 5-HT-2A antibody; 5-hydroxytryptamine(serotonin) receptor 2A, G protein-coupled antibody; 5-hydroxytryptamine 2A receptor antibody; 5-hydroxytryptamine receptor 2A antibody; 5HT2A_HUMAN antibody; HTR 2 antibody; HTR 2A antibody; HTR2 antibody; HTR2, formerly antibody; HTR2A antibody; serotonin 5-HT-2 receptor, formerly antibody; serotonin 5-HT-2A receptor antibody; Serotonin receptor 2A antibody

other names :

5-hydroxytryptamine receptor 2A; 5-hydroxytryptamine receptor 2A; 5-hydroxytryptamine receptor 2A; 5-HT-2A; 5-HT2 receptor; serotonin 5-HT-2A receptor; 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled; Serotonin receptor 2A

products gene name :

HTR2A

other gene names :

HTR2A; HTR2A; HTR2; 5-HT2A; HTR2; 5-HT-2; 5-HT-2A

uniprot entry name :

5HT2A_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

471

specificity :

No cross reactivity with other proteins

purity :

Immunogen affinity purified.

form :

Lyophilized

storage stability :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

app notes :

Western Blot (WB): . Concentration: 0.1-0.5ug/ml. Tested Species: Hu, Ms, Rat. Predicted Species: n/a. Antigen Retrieval: n/a. Immunohistochemistry (Paraffin-embedded Section): . Concentration: 0.5-1ug/ml. Tested Species: Ms, Rat. Predicted Species: Hu. Antigen Retrieval: By Heat. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.

other info1 :

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human 5HT2A Receptor (418-432aa AYKSSQLQMGQKKNS), different from the mouse sequence by one amino acid.

other info2 :

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

products description :

Description: Rabbit IgG polyclonal antibody for 5-hydroxytryptamine receptor 2A(HTR2A) detection. Tested with WB, IHC-P in Human, Mouse, Rat. Background: The mammalian HTR2A(5-HT2A receptor) is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor(GPCR). This is the main excitatory receptor subtype among the GPCRs for serotonin(5-HT), although 5-HT2A may also have an inhibitory effect on certain areas such as the visual cortex and the orbit frontal cortex. This receptor was given importance first as the target of psychedelic drugs like LSD. Later it came back to prominence because it was also found to be mediating, at least partly, the action of many antipsychotic drugs, especially the atypical ones.5-HT2A also happens to be a necessary receptor for the spread of the human polyoma virus called JC virus. Sparkes et al.(1991) concluded that the gene is located on 13q14-q21 in man and on chromosome 14 in the mouse.

ncbi gi num :

543727

ncbi acc num :

P28223.2

uniprot acc num :

P28223

ncbi mol weight :

43,940 Da

ncbi pathways :

Amine Ligand-binding Receptors Pathway (106363); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886); GPCRs, Other Pathway (198765); Gap Junction Pathway (83072)

ncbi summary :

This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

uniprot summary :

5-HT(2A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production. Belongs to the G-protein coupled receptor 1 family. Protein type: Membrane protein, integral; GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 13q14-q21. Cellular Component: cell soma; axon; integral to plasma membrane; cytoplasmic membrane-bound vesicle; plasma membrane; dendritic shaft; caveola; cytosol. Molecular Function: serotonin binding; serotonin receptor activity; protein complex binding; G-protein alpha-subunit binding; drug binding. Biological Process: cell death; urinary bladder smooth muscle contraction; phosphoinositide 3-kinase cascade; negative regulation of potassium ion transport; thermoregulation; regulation of dopamine secretion; positive regulation of MAP kinase activity; synaptic transmission; behavioral response to cocaine; positive regulation of cell proliferation; detection of temperature stimulus involved in sensory perception of pain; artery smooth muscle contraction; serotonin receptor signaling pathway; regulation of behavior; aging; response to drug; serotonin receptor, phospholipase C activating pathway; regulation of hormone secretion; negative regulation of synaptic transmission, glutamatergic; positive regulation of phosphatidylinositol biosynthetic process; sleep; memory; cellular calcium ion homeostasis; detection of mechanical stimulus involved in sensory perception of pain; positive regulation of peptidyl-tyrosine phosphorylation; phospholipase C activation; release of sequestered calcium ion into cytosol; positive regulation of glycolysis; positive regulation of vasoconstriction; positive regulation of fat cell differentiation. Disease: Schizophrenia; Alcohol Dependence; Anorexia Nervosa, Susceptibility To, 1; Obsessive-compulsive Disorder; Major Depressive Disorder

size1 :

0.1 mg

price1 :

245 USD

more info or order :

MyBioSource product webpage