Anti-Telomerase antibody | MyBioSource MBS175199 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-Telomerase antibody

catalog :

MBS175199

quantity :

0.1 mg

price :

245 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

mouse, rat

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS175199

products type :

Antibody

products full name :

Anti-Telomerase antibody

products short name :

Telomerase

products name syn :

Telomerase reverse transcriptase; telomerase reverse transcriptase; EST2 antibody; hEST2 antibody; htert antibody; TCS1 antibody; Telomerase associated protein 2 antibody; Telomerase Catalytic Subunit antibody; Telomerase reverse transcriptase antibody; Telomerase-associated protein 2 antibody; Telomere Reverse Transcriptase antibody; TERT antibody; TERT_HUMAN antibody; TP2 antibody; TRT antibody

other names :

Telomerase reverse transcriptase; Telomerase reverse transcriptase; telomerase reverse transcriptase; telomerase catalytic subunit; telomerase reverse transcriptase beta; telomerase reverse transcriptase; Telomerase catalytic subunit

products gene name :

TERT

other gene names :

Tert; Tert; TR; TP2; TRT; EST2; TCS1

uniprot entry name :

TERT_MOUSE

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Mouse, Rat

sequence length :

1122

specificity :

No cross reactivity with other proteins.

purity :

Immunogen affinity purified.

form :

Lyophilized

storage stability :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB)

app notes :

Western Blot (WB): Concentration: 0.1-0.5ug/ml. Tested Species: Ms, Rat. Predicted Species: n/a. Antigen Retrieval: n/a. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarites. Other applications have not been tested. Optimal dilutions should be determined by end users.

other info1 :

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of mouse Telomerase (15-30aa RSRYREVWPLATFVRR), identical to the related rat sequence.

other info2 :

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

products description :

Description: Rabbit IgG polyclonal antibody for Telomerase reverse transcriptase(TERT) detection. Tested with WB in Mouse, Rat. Background: TERT(Telomerase reverse transcriptase), is a catalytic subunit of the enzyme telomerase. Its absence(usually as a result of a chromosomal mutation) is associated with the disorder Cri du chat. The TERT gene was mapped to chromosome 5p15.33T by Meyerson, M. Elomerase lengthens telomeres in DNA strands, thereby allowing senescent cells that would otherwise become postmitotic and undergo apoptosis to exceed the Hayflick limit and become potentially immortal, as is often the case with cancerous cells. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells, resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mice suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks.

ncbi gi num :

6226781

ncbi acc num :

O70372.1

uniprot acc num :

O70372

ncbi mol weight :

127,978 Da

ncbi pathways :

Cell Cycle Pathway (971095); Chromosome Maintenance Pathway (1000863); Disease Pathway (970606); Extension Of Telomeres Pathway (1000867); HTLV-I Infection Pathway (373903); HTLV-I Infection Pathway (373889); IL-2 Signaling Pathway (198331); Id Signaling Pathway (198411); PluriNetWork Pathway (198307); RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway (1000750)

uniprot summary :

TERT: telomerase reverse transcriptase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The holoenzyme consists of TERT and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced isoforms have been identified, although the full-length sequence of some variants has not been determined. Protein type: Nucleolus; Transferase; DNA-binding; EC 2.7.7.49. Cellular Component: nucleoplasm; PML body; chromosome, telomeric region; mitochondrion; telomerase holoenzyme complex; cytoplasm; chromosome; ribonucleoprotein complex; nucleus. Molecular Function: transferase activity; telomerase activity; protein binding; protein homodimerization activity; RNA-directed RNA polymerase activity; DNA binding; metal ion binding; telomeric DNA binding; RNA-directed DNA polymerase activity; telomeric template RNA reverse transcriptase activity; tRNA binding; nucleotidyltransferase activity. Biological Process: mitochondrion organization and biogenesis; DNA strand elongation; RNA-dependent DNA replication; positive regulation of hair cycle; positive regulation of nitric-oxide synthase activity; telomere maintenance via telomerase; age-dependent telomere shortening; positive regulation of Wnt receptor signaling pathway; RNA interference, production of siRNA

size1 :

0.1 mg

price1 :

245 USD

more info or order :

MyBioSource product webpage