antibody

Anti-SPARC antibody

MBS175191

0.1 mg

245 USD

polyclonal

rabbit

nonconjugated

western blot, immunohistochemistry, immunohistochemistry - paraffin section

Antibody

Anti-SPARC antibody

SPARC

SPARC; secreted protein, acidic, cysteine-rich(osteonectin); AA517111 antibody; Basement membrane protein 40 antibody; Basement-membrane protein 40 antibody; BM 40 antibody; BM-40 antibody; BM40 antibody; Cysteine rich protein antibody; hm:zeh0062 antibody; MGC128090 antibody; ON antibody; Osteonectin antibody; Secreted acidic cystein rich glycoprotein antibody; Secreted protein acidic and rich in cysteine antibody; Secreted protein acidic cysteine rich(osteonectin) antibody; Secreted protein acidic cysteine rich antibody; SPARC antibody; SPRC antibody; SPRC_HUMAN antibody

SPARC; SPARC; SPARC; BM-40; osteonectin; cysteine-rich protein; basement-membrane protein 40; secreted protein acidic and rich in cysteine; secreted protein, acidic, cysteine-rich (osteonectin); Basement-membrane protein 40; BM-40; Osteonectin; ON; Secreted protein acidic and rich in cysteine

SPARC

SPARC; SPARC; ON; ON; BM-40; ON

SPRC_HUMAN

Polyclonal

IgG

Rabbit

Human

303

Immunogen affinity purified.

Lyophilized

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human SPARC (284-303aa DEWAGCFGIKQKDIDKDLVI).

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Description: Rabbit IgG polyclonal antibody for SPARC(SPARC) detection. Tested with WB, IHC-P in Human. Background: SPARC, secreted protein acidic and rich in cysteine, also known as Osteonectin is a protein that in humans is encoded by the SPARC gene. The human SPARC gene is 26.5 kb long, and contains 10 exons and 9 introns and is located on chromosome 5q31-q33. SPARC is a glycoprotein of 40 kD. SPARC is an acidic, cysteine-rich glycoprotein consisting of a single polypeptide chain that can be broken into 4 domains: 1) an Ca++ binding domains near the glutamic acidic-rich region at the amino terminus(domain I), 2) a cysteine- rich(domain II), 3) a hydrophilic region(domain III) and 4) an EF hand motif at the carboxy terminus region(domain IV). Osteonectin is a glycoprotein in the bone that binds sodium. It is secreted by osteoblasts during bone formation, initiating mineralization and promoting mineral crystal formation. Osteonectin also shows affinity for collagen in addition to bone mineral calcium. A correlation between osteonectin over expression and ampullary cancers and chronic pancreatitis has been found.

129283

P09486.1

P09486

34,632 Da

Binding And Uptake Of Ligands By Scavenger Receptors Pathway 771599!!ECM Proteoglycans Pathway 833812!!Extracellular Matrix Organization Pathway 576262!!Hemostasis Pathway 106028!!Platelet Activation, Signaling And Aggregation Pathway 106034!!Platelet Degranulation Pathway 106050!!Response To Elevated Platelet Cytosolic Ca2+ Pathway 106048!!Scavenging By Class H Receptors Pathway 833817!!Senescence And Autophagy Pathway 198780!!TGF-beta Receptor Signaling Pathway 198774

This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. [provided by RefSeq, Dec 2011]

0.1 mg

245 USD