antibody

Anti-XAF1 antibody

MBS175187

0.1 mg

245 USD

polyclonal

rabbit

nonconjugated

western blot, immunohistochemistry, immunohistochemistry - paraffin section

Antibody

Anti-XAF1 antibody

XAF1

XIAP-associated factor 1; XIAP associated factor 1; BIRC 4 binding protein antibody; BIRC4 binding protein antibody; BIRC4-binding protein antibody; BIRC4BP antibody; HSXIAPAF 1 antibody; HSXIAPAF1 antibody; XAF 1 antibody; XAF1 antibody; XAF1_HUMAN antibody; XIAP associated factor 1 antibody; XIAP-associated factor 1 antibody; XIAPAF1 antibody

XIAP-associated factor 1; XIAP-associated factor 1; XIAP-associated factor 1; BIRC4 binding protein; BIRC4-binding protein; XIAP associated factor 1; BIRC4-binding protein

XAF1

XAF1; XAF1; BIRC4BP; XIAPAF1; HSXIAPAF1; BIRC4BP; XIAPAF1

XAF1_HUMAN

Polyclonal

IgG

Rabbit

Human

301

Immunogen affinity purified.

Lyophilized

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human XAF1 (283-301aa QEKCRWLASSKGKQVRNFS).

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Description: Rabbit IgG polyclonal antibody for XIAP-associated factor 1(XAF1) detection. Tested with WB, IHC-P in Human. Background: XIAP associated factor-1, also known as XAF1, is a human gene. X-linked inhibitor of apoptosis(XIAP; MIM 300079) is a potent member of the IAP family. All members of this family possess baculoviral IAP(BIR) repeats, cysteine-rich domains of approximately 80 amino acids that bind and inhibit caspases. XAF1 antagonizes the anticaspase activity of XIAP and may be important in mediating apoptosis resistance in cancer cells. And alteration in XAF1 and XIAP RNA expression levels may lead to increased apoptotic resistance and proliferation due to unregulated XIAP function in cancer cells.

74736479

Q6GPH4.1

Q6GPH4

34,543 Da

Cytokine Signaling In Immune System Pathway 366171!!Immune System Pathway 106386!!Interferon Signaling Pathway 187103!!Interferon Alpha/beta Signaling Pathway 187104

This gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and proteins which interfere with their activity, such as the encoded protein, affect the progress of the apoptosis signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

0.1 mg

245 USD