antibody

Anti-CYP11A1 antibody

MBS175168

0.1 mg

245 USD

polyclonal

rabbit

nonconjugated

western blot, immunohistochemistry, immunohistochemistry - paraffin section

Antibody

Anti-CYP11A1 antibody

CYP11A1

Cholesterol side-chain cleavage enzyme, mitochondrial; cytochrome P450, family 11, subfamily A, polypeptide 1; Cholesterol 20 22 desmolase antibody; Cholesterol desmolase antibody; Cholesterol monooxygenase(side chain cleaving) antibody; Cholesterol side chain cleavage enzyme antibody; Cholesterol side chain cleavage enzyme mitochondrial antibody; Cholesterol side-chain cleavage enzyme antibody; CP11A_HUMAN antibody; CYP 11A antibody; CYP11A antibody; CYP11A1 antibody; CYPXIA1 antibody; Cytochrome P450 11A1 antibody; Cytochrome P450 11A1 mitochondrial antibody; Cytochrome P450 family 11 subfamily A polypeptide 1 antibody; Cytochrome P450 subfamily XIA(cholesterol side chain cleavage) antibody; Cytochrome P450 subfamily XIA antibody; Cytochrome P450(scc) antibody; Cytochrome P450C11A1 antibody; mitochondrial antibody; P450(scc) antibody; P450SCC antibody; Steroid 20 22 lyase antibody

Cholesterol side-chain cleavage enzyme, mitochondrial; Cholesterol side-chain cleavage enzyme, mitochondrial; cholesterol side-chain cleavage enzyme, mitochondrial; steroid 20-22-lyase; cytochrome P450 11A1; cytochrome P450(scc); cytochrome P450C11A1; cholesterol 20-22 desmolase; cholesterol monooxygenase (side-chain cleaving); cytochrome P450, subfamily XIA (cholesterol side chain cleavage); cytochrome P450, family 11, subfamily A, polypeptide 1; CYPXIA1; Cholesterol desmolase; Cytochrome P450 11A1; Cytochrome P450(scc)

CYP11A1

CYP11A1; CYP11A1; CYP11A; CYPXIA1; P450SCC; CYP11A

CP11A_HUMAN

Polyclonal

IgG

Rabbit

Human

521

Immunogen affinity purified.

Lyophilized

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunohistochemistry (IHC) Formalin

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human CYP11A1 (507-521aa ISFTFWPFNQEATQQ).

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Description: Rabbit IgG polyclonal antibody for Cholesterol side-chain cleavage enzyme, mitochondrial(CYP11A1) detection. Tested with WB, IHC-P, IHC-F in Human. Background: CYP11A1(Cytochrome p450, family 11, subfamily A, polypeptide 1), also called CYTOCHROME P450SCC, CYTOCHROME P450C11A1 or CYP11A, is a mitochondrial enzyme associated with the conversion of cholesterol to pregnenolone. CYP11A1 is a member of the cytochrome P450 superfamily of enzymes. The CYP11A1 gene is mapped on 15q24.1. Expression of the CYP11A1 gene may play a role in skin physiology and pathology and that cutaneous proopiomelanocortin activity may be autoregulated by a feedback mechanism involving glucocorticoids synthesized locally by Slominski et al. Using in vitro studies, CYP11A1 catalyzed the side-chain cleavage of 7-dehydrocholesterol to form 7-dehydropregnenolone. In addition, CYP11A1 catalyzed the metabolism of biologically inert vitamin D3, which is formed from 7-dehydrocholesterol, to form 2 hydroxylated products, 20-hydroxyvitamin D3 and 20, 22-dihydroxyvitamin D3. Mutations in the CYP11A1 gene cause congenital adrenal insufficiency with partial or complete 46, XY sex reversal.

143811381

P05108.2

P05108

42,152 Da

Biological Oxidations Pathway (105698); Corticotropin-releasing Hormone Pathway (920957); Cytochrome P450 - Arranged By Substrate Type Pathway (105700); Endogenous Sterols Pathway (105701); Glucocorticoid Mineralcorticoid Metabolism Pathway (198902); Metabolic Pathways (132956); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); Metabolism Of Steroid Hormones And Vitamin D Pathway (106150); Ovarian Steroidogenesis Pathway (790011)

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. [provided by RefSeq, Jul 2008]

CYP11A1: Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone. Defects in CYP11A1 are the cause of adrenal insufficiency congenital with 46,XY sex reversal (AICSR). A rare disorder that can present as acute adrenal insufficiency in infancy or childhood. ACTH and plasma renin activity are elevated and adrenal steroids are inappropriately low or absent; the 46,XY patients have female external genitalia, sometimes with clitoromegaly. The phenotypic spectrum ranges from prematurity, complete underandrogenization, and severe early-onset adrenal failure to term birth with clitoromegaly and later-onset adrenal failure. Patients with congenital adrenal insufficiency do not manifest the massive adrenal enlargement typical of congenital lipoid adrenal hyperplasia. Belongs to the cytochrome P450 family. Protein type: Lipid Metabolism - C21-steroid hormone; EC 1.14.15.6; Oxidoreductase; Mitochondrial. Chromosomal Location of Human Ortholog: 15q23-q24. Cellular Component: mitochondrial crista; mitochondrion; mitochondrial matrix; perikaryon. Molecular Function: cholesterol monooxygenase (side-chain-cleaving) activity; iron ion binding; cholesterol binding; heme binding. Biological Process: steroid metabolic process; response to alkaloid; maternal process involved in pregnancy; dibenzo-p-dioxin metabolic process; response to insecticide; estrogen biosynthetic process; response to L-ascorbic acid; response to salt stress; response to vitamin E; Leydig cell differentiation; biphenyl metabolic process; cerebellum development; response to gamma radiation; response to corticosterone stimulus; response to drug; cholesterol metabolic process; progesterone biosynthetic process; fractalkine metabolic process; phthalate metabolic process; hippocampus development; mating behavior; vitamin D metabolic process; Schwann cell differentiation; response to genistein; response to hydrogen peroxide; xenobiotic metabolic process; C21-steroid hormone biosynthetic process; sterol metabolic process; granulosa cell differentiation; phenol metabolic process. Disease: Adrenal Insufficiency, Congenital, With 46,xy Sex Reversal, Partial Or Complete

0.1 mg

245 USD