antibody

Anti-GST3/GST pi antibody

MBS175164

0.1 mg

245 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, immunohistochemistry, immunohistochemistry - paraffin section

Antibody

Anti-GST3/GST pi antibody

GST3/GST pi

Glutathione S-transferase P 1(Gst P1); glutathione S-transferase pi 1; Deafness antibody; Deafness X-linked 7 antibody; DFN7 antibody; FAEES3 antibody; Fatty Acid Ethyl Ester Synthase III antibody; Glutathione S Transferase 3 antibody; Glutathione S Transferase Pi antibody; Glutathione S-transferase P antibody; Glutathione S-transferase pi 1 antibody; GST class-pi antibody; GST3 antibody; GSTP antibody; Gstp1 antibody; GSTP1-1 antibody; GSTP1_HUMAN antibody; PI antibody; X linked 7 antibody

Glutathione S-transferase P; Glutathione S-transferase P; glutathione S-transferase P; GSTP1-1; GST class-pi; deafness, X-linked 7; epididymis secretory protein Li 22; fatty acid ethyl ester synthase III; glutathione S-transferase pi 1; GST class-pi; GSTP1-1

GSTP1

GSTP1; GSTP1; PI; DFN7; GST3; GSTP; FAEES3; HEL-S-22; FAEES3; GST3

GSTP1_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

210

Immunogen affinity purified.

Lyophilized

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Western Blot (WB): . Concentration: 0.1-0.5ug/ml. Tested Species: Hu, Rat. Concluded Species: Ms. Antigen Retrieval: n/a. Immunohistochemistry (IHC-P): . Concentration: 0.5-1ug/ml. Tested Species: Hu . Concluded Species: n/a. Antigen Retrieval: By Heat

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human GST3/GST pi (12-32aa RGRCAALRMLLADQGQSWKEE), different from the related rat and mouse sequences by two amino acids.

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Description: Rabbit IgG polyclonal antibody for Glutathione S-transferase P(GSTP1) detection. Tested with WB, IHC-P in Human, Mouse, Rat. Background: Glutathione S-transferases pi, also known as GST3, present in all tissues and cells, with the exception of red cells, in which only erythrocyte GST(GSTe) is observed. The GST-pi gene has 7 exons and 6 introns contained within approximately 2.8 kilobases. The GST-pi gene is mapped to chromosome 11. Placental glutathione-S-transferase-pi mRNA is abundantly expressed in human skin. GSTP does not contribute in vivo to the formation of glutathione conjugates of acetaminophen but plays a novel and unexpected role in the toxicity of this compound.

121746

P09211.2

P09211

23,356 Da

4-hydroxy-2-nonenal Detoxification Pathway (703096); Arachidonate Epoxygenase / Epoxide Hydrolase Pathway (198838); Biological Oxidations Pathway (105698); Cellular Responses To Stress Pathway (645258); Chemical Carcinogenesis Pathway (673221); Chemical Carcinogenesis Pathway (673237); Detoxification Of Reactive Oxygen Species Pathway (941400); Diurnally Regulated Genes With Circadian Orthologs Pathway (198813); Drug Metabolism - Cytochrome P450 Pathway (83032); Drug Metabolism - Cytochrome P450 Pathway (427)

Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]

GSTP1: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. Homodimer. Interacts with CDK5. Belongs to the GST superfamily. Pi family. Protein type: Transferase; EC 2.5.1.18; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450; Other Amino Acids Metabolism - glutathione. Chromosomal Location of Human Ortholog: 11q13. Cellular Component: extracellular space; mitochondrion; cytoplasm; plasma membrane; intracellular; cytosol; nucleus; vesicle. Molecular Function: JUN kinase binding; protein binding; glutathione transferase activity; kinase regulator activity. Biological Process: negative regulation of MAP kinase activity; negative regulation of JNK activity; central nervous system development; negative regulation of MAPKKK cascade; negative regulation of acute inflammatory response; negative regulation of tumor necrosis factor production; negative regulation of interleukin-1 beta production; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of stress-activated MAPK cascade; regulation of stress-activated MAPK cascade; negative regulation of biosynthetic process; response to reactive oxygen species; glutathione metabolic process; negative regulation of nitric-oxide synthase biosynthetic process; negative regulation of fibroblast proliferation; positive regulation of superoxide release; xenobiotic metabolic process; negative regulation of protein kinase activity; negative regulation of apoptosis

0.1 mg

245 USD