Anti-CYP11B1 antibody | MyBioSource MBS175139 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-CYP11B1 antibody

catalog :

MBS175139

quantity :

0.1 mg

price :

245 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS175139

products type :

Antibody

products full name :

Anti-CYP11B1 antibody

products short name :

CYP11B1

products name syn :

Cytochrome P450 11B1, mitochondrial; cytochrome P450, family 11, subfamily B, polypeptide 1; CPN1 antibody; CYP11B antibody; CYPXIB1 antibody; Cytochrome P 450c11 antibody; Cytochrome P450 11B1, mitochondrial antibody; Cytochrome p450 XIB1 antibody; Cytochrome P450, family 11, subfamily B, polypeptide 1 antibody; Cytochrome P450, subfamily XIB(steroid 11 beta hydroxylase), polypeptide 1 antibody; Cytochrome P450C11 antibody; FHI antibody; P 450C11 antibody; P450C11 antibody; S11BH antibody; Steroid 11 beta hydroxylase antibody; Steroid 11 beta monooxygenase antibody

other names :

Cytochrome P450 11B1, mitochondrial; Cytochrome P450 11B1, mitochondrial; cytochrome P450 11B1, mitochondrial; CYPXIB1; cytochrome P450C11; cytochrome P-450c11; cytochrome p450 XIB1; steroid 11-beta-hydroxylase; steroid 11-beta-monooxygenase; cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 1; cytochrome P450, family 11, subfamily B, polypeptide 1; CYPXIB1; Cytochrome P-450c11; Cytochrome P450C11; Steroid 11-beta-hydroxylase (EC:1.14.15.4)

products gene name :

CYP11B1

other gene names :

CYP11B1; CYP11B1; FHI; CPN1; CYP11B; P450C11; S11BH; Cytochrome P450C11

uniprot entry name :

C11B1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

503

purity :

Immunogen affinity purified.

form :

Lyophilized

storage stability :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB)

other info1 :

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human CYP11B1 (436-450aa RNFYHVPFGFGMRQC).

other info2 :

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

products description :

Description: Rabbit IgG polyclonal antibody for Cytochrome P450 11B1, mitochondrial(CYP11B1) detection. Tested with WB in Human. Background: CYP11B1(Cytochrome p450, family 11, subfamily B, polypeptide 1), also called Steroid 11-beta-hydroxylase or P450C11, is a steroid hydroxylase found in the zona fasciculata. The CYP11B1 gene functions primarily in mitochondria in the zona fasciculata of the adrenal cortex to convert 11-deoxycortisol to cortisol and 11-deoxycorticosterone to corticosterone. CYP11B1 is a member of the cytochrome P450 superfamily of enzymes. It is mapped on 8q24.3. The CYP11B1 gene contains 9 exons and spans 6.5 kb. Using RT-PCR, Kayes-Wandover and White detected CYP11B1 mRNA in human cardiac tissue samples from left and right atria, aorta, apex, intraventricular septum, and atrioventricular node, as well as whole adult and fetal heart. Ventricles did not express CYP11B1. In patients with 11-beta-hydroxylase deficiency leading to hypertension and congenital adrenal hyperplasia, Pascoe et al. identified mutations in the CYP11B1 gene.

ncbi gi num :

215274267

ncbi acc num :

P15538.5

uniprot acc num :

P15538

ncbi mol weight :

49,750 Da

ncbi pathways :

Biological Oxidations Pathway 105698!!C21-Steroid Hormone Biosynthesis, Progesterone = Corticosterone/aldosterone Pathway 413394!!C21-Steroid Hormone Biosynthesis, Progesterone = Corticosterone/aldosterone Pathway 468295!!C21-Steroid Hormone Biosynthesis, Progesterone = Cortisol/cortisone Pathway 413395!!C21-Steroid Hormone Biosynthesis, Progesterone = Cortisol/cortisone Pathway 468370!!Corticotropin-releasing Hormone Pathway 920957!!Cytochrome P450 - Arranged By Substrate Type Pathway 105700!!Endogenous Sterols Pathway 105701!!Glucocorticoid Biosynthesis Pathway 106152!!Metabolic Pathways 132956

ncbi summary :

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]

size :

0.1 mg

price :

245 USD

more info or order :

MyBioSource product webpage