product summary
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company name :
MyBioSource
product type :
antibody
product name :
Anti-Angiopoietin 2 antibody
catalog :
MBS175128
quantity :
0.1 mg
price :
245 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS175128
products type :
Antibody
products full name :
Anti-Angiopoietin 2 antibody
products short name :
Angiopoietin 2
products name syn :
Angiopoietin-2(ANG-2); angiopoietin 2; AGPT 2 antibody; Agpt2 antibody; ANG 2 antibody; ANG-2 antibody; ANG2 antibody; Angiopoietin 2a antibody; Angiopoietin 2B antibody; Angiopoietin-2 antibody; Angiopoietin2 antibody; ANGP2_HUMAN antibody; ANGPT 2 antibody; ANGPT2 antibody; ANGPT-2 antibody; Tie2 ligand antibody
other names :
Angiopoietin-2; Angiopoietin-2; angiopoietin-2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a; angiopoietin 2
products gene name :
ANGPT2
other gene names :
ANGPT2; ANGPT2; ANG2; AGPT2; ANG-2
uniprot entry name :
ANGP2_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human
sequence length :
496
purity :
Immunogen affinity purified.
form :
Lyophilized
storage stability :
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
tested application :
Western Blot (WB)
other info1 :
Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Angiopoietin 2 (454-468aa NLNGMYYPQRQNTNK).
other info2 :
Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
products description :
Description: Rabbit IgG polyclonal antibody for Angiopoietin-2(ANGPT2) detection. Tested with WB in Human. Background: Angiopoietin 1 and Angiopoietin 2 are important for development of the endothelium, by regulating tyrosine phosphorylation of the membrane receptor Tie 2. Angiopoietin 2 is only 60% homologous with Angiopoietin 1. Angiopoietin-2 is a naturally occurring antagonist of angiopoietin-1 that competes for binding to the TIE2 receptor and blocks ANGPT1-induced TIE2 autophosphorylation. Angiopoietin 1 binding to Tie 2 causes phosphorylation of the receptor. Angiopoietin 2 competes for this binding, and thus blocks receptor phosphorylation. Angiopoietin 2 expression occurs at sites of vascular remodelling: dorsal aorta and major aortic branches, ovary, placenta and uterus.
ncbi gi num :
12229555
ncbi acc num :
O15123.1
uniprot acc num :
O15123
ncbi mol weight :
56,848 Da
ncbi pathways :
Angiopoietin Receptor Tie2-mediated Signaling Pathway 137917!!Cell Surface Interactions At The Vascular Wall Pathway 106062!!HIF-1 Signaling Pathway 695200!!Hemostasis Pathway 106028!!PI3K-Akt Signaling Pathway 692234!!PI3K-Akt Signaling Pathway 692979!!Rap1 Signaling Pathway 868086!!Rap1 Signaling Pathway 878042!!Ras Signaling Pathway 868085!!Tie2 Signaling Pathway 106063
ncbi summary :
The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
size :
0.1 mg
price :
245 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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