Anti-NMDAR2B antibody | MyBioSource MBS175112 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-NMDAR2B antibody

catalog :

MBS175112

quantity :

0.1 mg

price :

245 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS175112

products type :

Antibody

products full name :

Anti-NMDAR2B antibody

products short name :

NMDAR2B

products name syn :

Glutamate receptor ionotropic, NMDA 2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B; AW490526 antibody; Glutamate[NMDA] receptor subunit epsilon 2 antibody; Glutamate[NMDA] receptor subunit epsilon-2 antibody; Glutamate Receptor Ionotropic N Methyl D Aspartate 2B antibody; Glutamate Receptor Ionotropic N Methyl D Aspartate subunit 2B antibody; Glutamate receptor ionotropic NMDA2B antibody; Glutamate receptor subunit epsilon 2 antibody; Glutamate receptor, ionotropic, NMDA2B(epsilon 2) antibody; GRIN 2B antibody; GRIN2B antibody; hNR 3 antibody; hNR3 antibody; MGC142178 antibody; MGC142180 antibody; N methyl D asparate receptor channel subunit epsilon 2 antibody; N METHYL D ASPARTATE RECEPTOR CHANNEL SUBUNIT EPSILON 2 antibody; N methyl D aspartate receptor subtype 2B antibody; N methyl D aspartate receptor subunit 2B antibody; N methyl D aspartate receptor subunit 3 antibody; N-methyl D-aspartate receptor subtype 2B antibody; N-methyl-D-aspartate receptor subunit 3 antibody; NMDA NR2B antibody; NMDA R2B antibody; Nmdar2b antibody; NMDE2 antibody; NMDE2_HUMAN antibody; NME2 antibody; NR2B antibody; NR3 antibody

other names :

Glutamate receptor ionotropic, NMDA 2B; Glutamate receptor ionotropic, NMDA 2B; glutamate receptor ionotropic, NMDA 2B; NR3; glutamate receptor subunit epsilon-2; N-methyl-D-aspartate receptor subunit 3; N-methyl D-aspartate receptor subtype 2B; glutamate [NMDA] receptor subunit epsilon-2; glutamate receptor, ionotropic, N-methyl D-aspartate 2B; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; NR2B; N-methyl-D-aspartate receptor subunit 3; NR3; hNR3

products gene name :

GRIN2B

other gene names :

GRIN2B; GRIN2B; MRD6; NR2B; hNR3; GluN2B; NMDAR2B; NMDAR2B; GluN2B; NMDAR2B; NR2B; NR3; hNR3

uniprot entry name :

NMDE2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

1484

purity :

Immunogen affinity purified.

form :

Lyophilized

storage stability :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB)

other info1 :

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human NMDAR2B (1131-1146aa, DFYLDQFRTKENSPHW), identical to the related mouse and rat sequence.

other info2 :

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

products description :

Description: Rabbit IgG polyclonal antibody for Glutamate receptor ionotropic, NMDA 2B(GRIN2B) detection. Tested with WB in Human, Mouse, Rat. Background: The N-methyl-D-aspartate receptor 2B, also names as GRIN2B. The sequence of the predicted 1,484-amino acid human protein is 98% and 96% identical to the sequences of the rat and mouse Nmdar2b proteins, respectively. Nmdar2B gene is located on mouse chromosome 6 between Rho and Ly49 centromerically and Glb telomerically. Mapping of the human NMDAR2B receptor subunit gene(GRIN2B) to chromosome 12p12 overexpression of NMDA receptor 2B(NR2B) in the forebrains of transgenic mice leads to enhanced activation of NMDA receptors, facilitating synaptic potentiation in response to stimulation at 10-100 Hz.

ncbi gi num :

14548162

ncbi acc num :

Q13224.3

uniprot acc num :

Q13224

ncbi mol weight :

166,367 Da

ncbi pathways :

Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (161033); Alcoholism Pathway (585563); Alcoholism Pathway (587116); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Amphetamine Addiction Pathway (547607); Amphetamine Addiction Pathway (550546); Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (511)

ncbi summary :

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008]

uniprot summary :

NMDAR2B: an NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, ligand-gated; Channel, calcium. Chromosomal Location of Human Ortholog: 12p12. Cellular Component: postsynaptic membrane; synaptic vesicle; neuron projection; cell surface; integral to plasma membrane; dendrite; plasma membrane; cell junction; N-methyl-D-aspartate selective glutamate receptor complex. Molecular Function: protein binding; extracellular-glutamate-gated ion channel activity; zinc ion binding; glycine binding; calcium channel activity; N-methyl-D-aspartate selective glutamate receptor activity. Biological Process: axon guidance; synaptic transmission, glutamatergic; behavioral fear response; startle response; in utero embryonic development; glutamate signaling pathway; regulation of synaptic plasticity; learning; memory; synaptic transmission; detection of mechanical stimulus involved in sensory perception of pain; behavioral response to pain; sensory organ development; response to ethanol; learning and/or memory; suckling behavior; ionotropic glutamate receptor signaling pathway; transport; ephrin receptor signaling pathway; regulation of excitatory postsynaptic membrane potential. Disease: Mental Retardation, Autosomal Dominant 6; Epileptic Encephalopathy, Early Infantile, 27

size1 :

0.1 mg

price1 :

245 USD

more info or order :

MyBioSource product webpage