Anti-P-Glycoprotein(MDR) antibody (monoclonal) | MyBioSource MBS175096 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-P-Glycoprotein(MDR) antibody (monoclonal)

catalog :

MBS175096

quantity :

0.1 mg

price :

245 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

PG-13

reactivity :

human

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS175096

products type :

Antibody

products full name :

Anti-P-Glycoprotein(MDR) antibody (monoclonal)

products short name :

P-Glycoprotein(MDR)

products name syn :

Multidrug resistance protein 1; ATP-binding cassette, sub-family B(MDR/TAP), member 1; CLCS; MDR1; P-GP; PGY1; ABC20; CD243; GP170; ATP-binding cassette sub-family B member 1; P-glycoprotein 1

other names :

Multidrug resistance protein 1; Multidrug resistance protein 1; multidrug resistance protein 1; P-glycoprotein 1; colchicin sensitivity; doxorubicin resistance; ATP-binding cassette, sub-family B (MDR/TAP), member 1; ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD_antigen: CD243

products gene name :

ABCB1

other gene names :

ABCB1; ABCB1; CLCS; MDR1; P-GP; PGY1; ABC20; CD243; GP170; MDR1; PGY1

uniprot entry name :

MDR1_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

PG-13

host :

Mouse

reactivity :

Human

sequence length :

1280

purity :

Ascites

form :

Lyophilized

storage stability :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunohistochemistry (IHC) Formalin, Immunocytochemistry ICC

other info1 :

Immunogen: Mixture of human and hamster drug-resistant whole cells and crude plasma membranes.

other info2 :

Contents: Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. Reconstitution: 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.

products description :

Description: Mouse IgG monoclonal antibody for P-Glycoprotein (MDR), ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1) detection. Tested with WB, IHC-P, IHC-F, ICC in Human. No cross reactivity with other proteins. Uniprot ID: P08183. Background: P-Glycoprotein,, also known as Multidrug Resistance 1(MDR1), is one of the ATP-binding cassette transporters family. P-glycoprotein-1 is involved in the transport of 3 of these protease inhibitors in vitro. MDR1 gene is mapped to the 7q21.1 by in situ hybridization. The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin.

ncbi gi num :

238054374

ncbi acc num :

P08183.3

uniprot acc num :

P08183

ncbi mol weight :

134,032 Da

ncbi pathways :

ABC Transporters Pathway (83035); ABC Transporters Pathway (436); ABC-family Proteins Mediated Transport Pathway (106573); Abacavir Transmembrane Transport Pathway (645350); Abacavir Transport And Metabolism Pathway (645349); Bile Secretion Pathway (193146); Bile Secretion Pathway (193095); Codeine And Morphine Metabolism Pathway (198831); Drug Induction Of Bile Acid Pathway (698755); HIF-1-alpha Transcription Factor Network Pathway (138045)

ncbi summary :

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]

uniprot summary :

ABCB1: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. Interacts with PSMB8. Protein type: Hydrolase; Cell adhesion; Transporter; Membrane protein, integral; Membrane protein, multi-pass; EC 3.6.3.44; Transporter, ABC family. Chromosomal Location of Human Ortholog: 7q21.12. Cellular Component: cell surface; membrane; plasma membrane; integral to membrane. Molecular Function: protein binding; ATPase activity, coupled to transmembrane movement of substances; transporter activity; xenobiotic-transporting ATPase activity; ATP binding. Biological Process: response to drug; transport; multidrug transport; xenobiotic transport; G2/M transition of mitotic cell cycle; transmembrane transport. Disease: Colchicine Resistance; Inflammatory Bowel Disease 13

size1 :

0.1 mg

price1 :

245 USD

more info or order :

MyBioSource product webpage