catalog number :
MBS175073
products full name :
Anti-Cathepsin D antibody (monoclonal)
products short name :
Cathepsin D
products name syn :
Cathepsin D; cathepsin D; CLN10; CPSD; cathepsin D(lysosomal aspartyl protease); ceroid-lipofuscinosis, neuronal 10
other names :
Cathepsin D; Cathepsin D; cathepsin D; lysosomal aspartyl protease; lysosomal aspartyl peptidase; ceroid-lipofuscinosis, neuronal 10; epididymis secretory sperm binding protein Li 130P; cathepsin D
products gene name :
CTSD
other gene names :
CTSD; CTSD; CPSD; CLN10; HEL-S-130P; CPSD
uniprot entry name :
CATD_HUMAN
storage stability :
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
tested application :
Western Blot (WB), Immunohistochemistry (IHC) Paraffin
other info1 :
Immunogen: Human liver cathepsin D.
other info2 :
Contents: Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. Reconstitution: 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.
products description :
Description: Mouse IgG monoclonal antibody for Cathepsin D, cathepsin D (CTSD) detection. Tested with WB, IHC-P in Human. No cross reactivity with other proteins. Uniprot ID: P07339. Background: Cathepsin D is one of the lysosomal proteinases. It is ubiquitously expressed and is involved in proteolytic degradation, cell invasion, and apoptosis. Cathepsin D is mapped to chromosome 11. The amino acid sequence predicted from the cDNA sequence shows that human cathepsin D consists of 412 amino acids with 20 and 44 amino acids in a pre- and a prosegment, respectively.
ncbi mol weight :
44,552 Da
ncbi pathways :
Adaptive Immune System Pathway 366160!!Ceramide Signaling Pathway 138023!!Collagen Degradation Pathway 730309!!Degradation Of The Extracellular Matrix Pathway 576263!!Direct P53 Effectors Pathway 137939!!Extracellular Matrix Organization Pathway 576262!!Immune System Pathway 106386!!LKB1 Signaling Events Pathway 137957!!Lysosome Pathway 99052!!Lysosome Pathway 96865
ncbi summary :
This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. [provided by RefSeq, Jul 2008]