Anti-N-Cadherin antibody (monoclonal) | MyBioSource MBS175069 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-N-Cadherin antibody (monoclonal)

catalog :

MBS175069

quantity :

0.1 mg

price :

245 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

NC-17

reactivity :

human, mouse, rat, chicken

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS175069

products type :

Antibody

products full name :

Anti-N-Cadherin antibody (monoclonal)

products short name :

N-Cadherin

products name syn :

Cadherin-2; cadherin 2, type 1, N-cadherin(neuronal); CDHN; NCAD; CD325; CDw325; Neural cadherin

other names :

Cadherin-2; Cadherin-2; cadherin-2; N-cadherin 1; neural cadherin; neural-cadherin; cadherin 2, N-cadherin (neuronal); calcium-dependent adhesion protein, neuronal; cadherin 2, type 1, N-cadherin (neuronal); CDw325; Neural cadherin; N-cadherin; CD_antigen: CD325

products gene name :

CDH2

other gene names :

CDH2; CDH2; CDHN; NCAD; CD325; CDw325; CDHN; NCAD; N-cadherin

uniprot entry name :

CADH2_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

NC-17

host :

Mouse

reactivity :

Human, Mouse, Rat, Rabbit, Chicken

sequence length :

906

purity :

Ascites

form :

Lyophilized

storage stability :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB), Immunohistochemistry (IHC) Formalin

other info1 :

Immunogen: Affinity purified chicken heart A-CAM.

other info2 :

Contents: Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. Reconstitution: 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.

products description :

Description: Mouse IgG monoclonal antibody for N-Cadherin, cadherin 2, type 1, N-cadherin (neuronal) (CDH2) detection. Tested with WB, IHC-F in Human, mouse, rat, rabbit, chicken. No cross reactivity with other proteins. Uniprot ID: P19022. Background: N-cadherin(NCAD) is a member of the cadherin cell-cell adhesion receptor family that includes P-, E-, and R-cadherin and liver cell adhesion molecule(L-CAM). N-Cadherin,, also known as Cadherin-2, encodes a 907-amino acid protein that includes a 159-amino acid signal sequence. Human and mouse nucleotide sequences are 96% identical. Mouse Ncad gene consists of 16 exons dispersed over more than 200 kb of genomic DNA. Human N-cadherin gene contains 16 exons and its sequence is highly similar to both the mouse NCAD gene(including the large first and second introns) and other cadherin genes. N-cadherin is mapped to 18q11.2. Cadherin regulates dendritic spine morphogenesis.

ncbi gi num :

116241277

ncbi acc num :

P19022.4

uniprot acc num :

P19022

ncbi mol weight :

97,040 Da

ncbi pathways :

Adherens Junctions Interactions Pathway (119533); Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); BDNF Signaling Pathway (712093); CDO In Myogenesis Pathway (160998); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Junction Organization Pathway (160966); Cell-Cell Communication Pathway (477132)

ncbi summary :

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product. [provided by RefSeq, Jul 2008]

uniprot summary :

CDH2: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. Interacts with CDCP1. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with PCDH8; this complex may also include TAOK2. The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway. Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 18q11.2. Cellular Component: cell-cell adherens junction; focal adhesion; lamellipodium; apical plasma membrane; integral to membrane; plasma membrane; synapse; catenin complex; intercellular junction; fascia adherens. Molecular Function: protein binding; gamma-catenin binding; beta-catenin binding; calcium ion binding; protein phosphatase binding; alpha-catenin binding. Biological Process: heterophilic cell adhesion; intercellular junction assembly and maintenance; muscle cell differentiation; cell migration; glial cell differentiation; positive regulation of MAPKKK cascade; calcium-dependent cell-cell adhesion; blood vessel morphogenesis; positive regulation of muscle cell differentiation; striated muscle cell differentiation; cell adhesion; homophilic cell adhesion

size1 :

0.1 mg

price1 :

245 USD

more info or order :

MyBioSource product webpage